 ruier123
|
http://sklsgb.swu.edu.cn/cn/uploads/allimg/130106/2-130106105030G4.jpg
教授、博士生導師
重慶市百人計劃特聘教授
重慶市巴渝學者
簡歷：
從本科填起
1988.9-1992.7 西南農業大學 學士
1992.9-1995.7 西南農業大學 碩士
1995. 7-1997.9 山東省煙臺蠶種場 技術員
1997.9 -2000.7 西南農業大學 博士
2000.7-2001.2 第四軍醫大學 博士后
2001.2 - 2005.7 美國俄亥俄醫學院 博士后
2005.7 -2009.5 美國俄亥俄醫科大學 助理教授
2009.5-2010.7 美國克利夫蘭醫學研究中心 項目專員
2010.1-2010.6 中美冠科生物技術公司腫瘤藥效學部 總監
2010.6- 家蠶基因組生物學國家重點實驗室 教授
主要科研領域與方向:
干細胞生物學、腫瘤生物學與轉化研究
科學成就：
申請者2010年5月回國前在美國從事多年干細胞生物學研究， 著重探討了腫瘤干細胞在腫瘤發生、形成上的機理，尋找腫瘤的特異性分子標志，就腫瘤干細胞的分子標記進行了原創性工作，發現和闡明了在腫瘤發生過程中原癌基因N-myc對干細胞的作用機理。并系統論證了多梳族轉錄因子在神經腫瘤干細胞的調控，為特異性阻斷此通路進行優化治療提供了可行性依據，為腫瘤的預后監控提供了新的重要檢測指標。
回國后建立了家蠶干細胞生物學實驗室，獲得重慶市“百人計劃”和“巴渝學者”擇優支持。以干細胞生物學作為家蠶基因組生物學國家重點實驗室發展的重要支撐方向之一，著重研究家蠶各成體干細胞在變態發育的分子機制，開展家蠶組織、器官內干細胞的識別、維持及其多向分化調控研究。以家蠶開展人類疾病的模型的研制，實現從昆蟲模型、到老鼠模型以及到人類疾病藥效的轉化研究。
近年在國內外重要期刊發表30篇以上，SCI文章20篇，影響因子超過100分，被SCI源文章廣泛引用。主持和參加國內973課題與美國NIH基金、美國癌癥研究協會重大科研項目多項。多次被相關國際學術會議選為執行主席和特邀報告人，共計獲邀參加國際會議并做大會報告10次以上。并被多家雜志邀請為審稿人。
代表性論文：
- Mao L, Ding J, Zha Y, Yang L, McCarthy B, King W, Hongjuan Cui, Ding H. HOXC9 links cell cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. Cancer Res., 2011 Jun 15;71(12):4314-24. Epub 2011 Apr 20.
- L Mao, J Ding, A Perdue, L Yang, Y Zha, M Ren, S Huang, Hongjuan Cui and H-F Ding, Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression. Oncogene (2011) 1–11.
- Gonit M, Zhang J, Salazar MD, Hongjuan Cui, Shatnawi A, Trumbly R, Ratnam M. Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements. Mol Endocrinol. 2011 Apr;25(4):621-34. Epub 2011 Feb 17.
- Tai Li, Zhao-Bo Cui, Xiao-Xue Ke, Juan Tan, Fang-Fang Li, Ting Li, Xiang-Wei Wang, and Hong-Juan Cui. Essential Role for p53 and Caspase-9 in DNA Damaging Drug-Induced Apoptosis in Neuroblastoma IMR32 Cells. DNA and Cell Biology, 2011 Dec;30(12):1045-50 Epub 2011 may 25.
- Tai Li, Lin Wang, Xiao-xue Ke, Man Xu, Zhao-bo Cui, Hongjuan Cui, DNA damaging drugs-induced apoptosis sensitized by N-myc in neuroblastoma cells. Cell Biology International, (2012) 36, 331–337. Epub ahead of print, DOI 10.1042/CBI20110231.
- Zhichuan Li, Zhongbing Zhang, Joe X. Xie, Xin Li, Jiang Tian, Hongjuan Cui, Hanfei Ding, Joseph I. Shapiro and Zijian Xie. Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells. 2011, Journal of Biological Chemistry, J Biol Chem. 2011 Sep 16;286(37):32394-403. Epub 2011 Jul 22.
- Xiangwei Wang, Lunshan Xu, Jianhua Wan, Xueyang Gong, Kui Zhang, Liang Yi, Zhonghuai Xiang, Minhui Xu, Hongjuan Cui. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. MCBI, DOI 10.1007/s11010-011-1222-6.
- Yang L, Hongjuan Cui, Wang Z, Zhang B, Ding J, Liu L, Ding HF. Loss of negative feedback control of nuclear factor-kappa B2 activity in lymphocytes leads to fatal lung inflammation. Am J pathol, 2010 Jun;176(6):2646-57. Epub 2010 Apr 2
- Yang H, Zhu L, Ebraheim NA, Liu X, Castillo S, Tang T, Liu J, Hongjuan Cui. 2009, Analysis of risk factors for recurrence after the resection of sacral chordoma combined with embolization. Spine J. 2009 Dec;9(12):972-80. Epub 2009 Oct 1.
- Ling Mao, Yuan-Peng Xia, Yu-Nan Zhou, Ruo-Lian Dai, Xue Yang, Shu-Jie Duan, Xian Qiao, Yuan-Wu Mei, Bo Hu and Hongjuan Cui, 2009 A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells [url=]Cancer Sci.[/url] 2009 Oct;100(10):1848-55. Epub 2009 Jun 26,.
- Goleeta Alam, Hongjuan Cui (co-principal author), Huilin Shi, Jane Ding, ling Mao, William A. Maltese, and Han-Fei Ding, MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. [url=]Am J Pathol.[/url] 2009 Aug; 175(2):856-66. Epub 2009 Jul 16.
- Huilin Shi, Hongjuan Cui, Goleeta Alam, William Gunning, Andrea Nestor, David Giovannucci, Ming Zhang, Han-Fei Ding, 2008. Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia, Journal of Comparative Neurology, 508: 867-878.
- Hongjuan Cui, Bo Hu, Tai Li, Jun Ma, Goleeta Alam, William T Gunning, and Han-Fei Ding, 2007. Bmi-1 is essential for the tumorigenicity of Neuroblastoma cells, American Journal of Pathology, 170 (4): 1370-1378.
- Hongjuan Cui, Jun Ma, Jane Ding, Tai Li, Goleeta Alam, and Han-Fei Ding, 2006, Bmi-1 regulates differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner, Journal of Biological Chemistry, 281 (45): 34696-34704.
- Hongjuan Cui, Tai Li, Han-Fei Ding, 2005, Linking of N-Myc to death receptor machinery in neuroblastoma cells, Journal of Biological Chemistry, 280: 9474-9481.
- Yongqing Wang, Hongjuan Cui (Co-principal author), Allen Schroering, Jane L. Ding, William S. lane, Gaël McGill, David E. Fisher and Han-Fei Ding. 2002. NF-ĸB2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nature Cell Biology. 4(11): 888-93.
- Hongjuan Cui, Allen Schroering, and Han-Fei Ding. 2002. p53 mediated DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in Sh-SY5Y neuroblastoma cells. Molecular Cancer Therapeutics. 1: 679-686.
聯系地址： 400716，西南大學 家蠶基因組生物學國家重點實驗室
電 話： 023-68251712
傳 真： 023-68251128
E-mail： hongjuan.cui@gmail.com
|
|
