中國藥科大學

張建軍碩士生導師簡介

教育、工作經歷：

1996-2000年碩士中國藥科大學藥物制劑
2002-2005年博士中國藥科大學藥物制劑
2000.11-2002.3國家藥品審評中心
2005,11-2006,8香港浸會大學訪問學者
2010.7-2011.12江蘇四環生物股份有限公司技術總監（企業柔性人才掛職）
2013.7-2014.6美國明尼蘇達大學訪問學者
2002.4-至今中國藥科大學藥學院藥劑教研室，中國藥科大學-震元制藥制劑合作開發實驗室負責人

主要研究方向：新制劑與新技術研究

具體研究興趣為：

1）藥物晶體工程
2）共晶及共無定型理論與技術
3）新液晶材料及其給藥系統
4）緩控釋制劑技術
5）納米制劑技術

基本情況：

副教授，碩士生導師，國家食品藥品監督管理局藥品審評專家。2010年獲中國藥學會-石藥青年藥劑學獎，2013年獲藥明康德生命化學獎，2014年獲江蘇省青藍工程中青年學術帶頭人。

主持了逾40余項校企合作課題的研究與產業化，研究劑型及技術全面，在應用技術領域及制劑生產第一線，在推動技術創新和科技成果轉化等方面有非常豐富的研發經驗和產業化經驗。參與國家重大新藥創制技術平臺和多項重大新藥創制項目。目前已申請專利40余項，已授權16項，轉讓5項。

注重藥物制劑理論基礎尤其是藥物晶體學的深入研究，重視新技術、新劑型的應用基礎，發表SCI論文26篇（第一作者或通訊作者），國內EI及核心期刊論文幾十篇，《中藥制劑新劑型與新技術》的副主編，并參與編寫了《藥劑學》、《藥劑學實驗》等多部藥劑學教材。

代表性SCI文章：

Zhang J, Gao Y, Qian S, Liu X, Zu H. Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion. Int J Pharm, 2011, 414(1-2):186-192.

Liu Y, Zhang J (contribution equally), Gao Y, Zhu J. Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. Int J Pharm, 2011, 413(1-2):103-109.

Gao Y, Qian S, Zhang J. Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull 2010, 58(7): 912-917.

Zhang J, Gao Y, Su F, Gong Z, Zhang Y. Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI(4)-2, a new nitric oxide-releasing derivative of oleanolic acid. Chem Pharm Bull. 2011, 59(6): 734-741.

Gao Y, Zu H, Zhang J*. Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation. J Pharm Pharmacol, 2011, 63(4): 483–490.

Zhang J, Zu H, Gao Y. Formation thermodynamics of adefovir dipivoxil-saccharin co-crystals. Acta Phys Chim Sin, 2011, 27(3): 547-552.

Gao Y, Zu H, Zhang J*. Pharmaceutical cocrystals. Prog Chem, 2010,22(5): 829-836.

Gao Y, Sun WJ, Zhang J*. Optimization of preparation and property studies on glycosylated albumin as drug carrier for nanoparticles. Pharmazie, 2011, 66(7): 484-490.

Gao Y, Sun WJ, Zhang J*. Albumin as drug carriers. Prog Chem, 2011, 23(8): 168-176.

Zhang J, Li C, Gao Y. Effect of poloxamer F 127 and paeonol on GMO-based liquid crystal transformation. Acta Chim Sin, 2011, 69(13): 1503-1508.

Zhang J, Lv H, Jiang K, Gao Y*. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011, 420(1):180-188.

Zhang J, Zheng Z, Gao Y*, Zhang Y. Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac. J Pharm Pharmacol, 2011, 63(12):1531-1538.

Gao Y, Li L,Zhang J*, Su F, Gong Z, Lai Y, Zhang Y. Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2，a novel NO-donor anti-cancer compound. Arch Pharm Res, 2012, 35(7): 1177-1186.

Zhang J, Liu D, Huang Y, Gao Y, Qian S. Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm, 2012, 436(1-2): 311-317.

Gao Y, Gao J, Liu Z, Kan H, Zu H, Sun W, Zhang J*, Qian S. Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals. Int J Pharm, 2012, 438(1-2): 327-335

Zhang J, Tan X, Gao J, Fan W, Gao Y, Qian S. Polymorphism of lornoxicam. J Pharm Pharmacol, 2013, 65(1): 44-52.

Zhang J, Huang Y, Liu D, Gao Y, Qian S. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. Eur J Pharm Sci, 2013, 48(4–5): 740–747.

Y Gao, J Liao, X Qi, J Zhang*. Coamorphous repaglinide–saccharin with enhanced dissolution. Int J Pharm, 2013, 450(1-2): 290-295.

Ma K, Zhang Y, Kan H, Cheng L, Luo L, Su Q, Gao J, Gao Y, Zhang J*. Thermodynamic and kinetic investigation on the crucial factors affecting adefovir dipivoxil-saccharin cocrystallization. Pharm Res, 2014, 31(7): 1766-1778.

Zhang J, Fu M, Zhang M, Xu L, Gao Y. Synthesis of oxidized glycerol monooleate-chitosan polymer and its hydrogel formation for sustained release of trimetazidine hydrochloride. Int J Pharm, 2014, 465(1-2):32-41.

Guo H, Miao N, Li T, Hao J, Gao Y, Zhang J*. Pharmaceutical coamorphous-a newly defined single-phase amorphous binary system. Prog Chem, 2014, 26(2-3): 478-486.

Huang Y, Zhang B, Gao Y, Zhang J*, Shi L. Baicalein-nicotinamide cocrystal with enhanced solubility, dissolution and oral bioavailability. J Pharm Sci, 2014, 103(8):2330-2337.

Wei Y, Li L, Xi Y, Qian S, Gao Y, Zhang J*. Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. Int J Pharm, 2014. Accepted

*: corresponding author

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