中國藥科大學

(1)針對“腫瘤生態學”因素在腫瘤轉移中的作用，開展微環境中腫瘤間質細胞及缺氧微環境對腫瘤轉移作用的相關機制研究，為抗腫瘤藥物研究提供理論依據；(2)通過腫瘤轉移相關機制研究，尋找新的藥物作用靶點，建立抗腫瘤轉移藥物篩選模型，為開發新型抗腫瘤藥物奠定基礎；(3)在前期藥物篩選的基礎上，進一步評價候選化合物體內外抗腫瘤作用，開展抗腫瘤藥物作用機制研究，為新藥開發提供儲備力量。

5.2近年主要主持及參與的課題：

(1)DT-13抗腫瘤轉移作用及分子機制研究

2011年國家自然科學基金青年基金項目（81102853,項目負責人）

(2)基于Norch-Dell4信號通路抗腫瘤血管新生靶點探討及rP47抗腫瘤作用研究

2011年教育部中央高校基本科研業務費專項基金（JKQ2011012,項目負責人）

(3)YS-1抗腫瘤轉移作用及分子機制研究；國家自然基金；編號810718418。

(4)抗腫瘤中藥一類新藥注射用藤黃酸臨床研究；重大新藥創制；編號2008ZX09101-024。

(5)抗腫瘤藥物澳洲茄邊堿的研究；重大新藥創制；編號2009ZX09103-389。

(6)新藥篩選核心技術規范化平臺建設及其科學應用；重大新藥創制；編號2009ZX09302。

(7)脂質體藥物工藝技術平臺；重大專項。

5.3近期發表的文章：

(1) Li Sun, Liu Yang，Sensen Lin, Jing Shang, Ji Liu, Ji Li, Shengtao Yuan, Luyong Zhang. Early growth response gene-1 and hypoxia-inducible factor-1α affect tumor metastasis via regulation of tissue factor during hypoxia. Acta Oncol. 2013 May; 52(4):842-51. doi: 10.3109/0284186X.2013.705890. Epub 2013 Feb 14.

(2) Li Sun, Jin Liu Sensen Lin , Wenting Shia , Jing Zhu , Guang Liang, Shengtao Yuan, Potent Anti-angiogenic Activity of B19-a Newly Synthesized Mono-Carbonyl Analogue of Curcumin. Chin J Nat Med (in press 2013).

(3) Renping Zhao, Li Sun, Sensen Lin, Boyang Yu, Luyong Zhang, Shengtao Yuan. The saponin monomer of dwarf lilyturf tuber, DT-13, exhibits the anti-angiogenesis activity under hypoxia and normoxia via different mechanisms. Chin J Nat Med (in press 2013).

(4) Dongdong Fang, Li Sun, Sensen Lin, Liqiang Zhou, Nan Su, Shengtao Yuan and Boyang Yu. Research on anti-cancer effects of Paclitaxel through stromal fibroblasts. Experimental Biology and Medicine 2012; 237: 1045-1055.

(5) Elysee, Su Nan, Hu wanfeng, Lin sensen, Sun Li*, Yuan shengtao*. Antitumor activity of Xiaoaiping injection on human gastric cancer SGC-7901 cells，2012，10(5): 339-346.

(6) Lin Sensen, Wan Shuying, Sun Li, Yuan shengtao. Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Science. 2012, 103(5):904-912.

(7) Zhou L, Sun L, Lin S, Fang D, Zhao R, Zhu J, Liu J, Chen L, Shi W, Yuan S, Zhu D Inhibition of angiogenic activity of hypoxic fibroblast cell line MRC-5 in vitro by topotecan. Medical Oncology. 2011, 28, (1 Supplement): 653-659.

(8) Li Sun, Sensen Lin, Renping Zhao, Boyang Yu, Shengtao Yuan, and Luyong Zhang. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biol. Pharm. Bull. 33(7) 1192-1198 (2010).

(9) SUN Li, LIN Sen-Sen, Yu Bo-Yang, YUAN Sheng-Tao, ZHANG Lu-Yong. High-throughput screening model for tissue factor inhibitor and effect of DT-13 on anti-tumor metastasis. Chin J Nat Med. Nov. 2010 Vol. 8 No. 6 466-470.

(10) Sensen Lin, Li Sun, Jialiang Hu, Shuying Wan, Renping Zhao, Shengtao Yuan, Luyong Zhang. Chemokine CXC motif receptor 6 contributes to cell migration during hypoxia ，Cancer Lett. 2009 Jun 28; 279(1):108-17.

(11) Sen-sen LIN, Li SUN, Yan-kai ZHANG, Ren-ping ZHAO, Wen-lu LIANG, Sheng-tao YUAN, Lu-yong ZHANG. Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases, Acta Pharmacologica Sinica. 2009 May; 30(5):628-36.

5.4近期申請的專利：

(1)短葶山麥冬C在制藥中的應用，已授權Zl200810196044.0

(2)組織因子抑制劑高通量篩選模型，專利號：101376907

(3)一種基因疫苗及其制備方法和在制藥中的應用，專利號：200910026786.3