中國藥科大學(xué)

譚寧華，女，1963年10月生，博士、教授、博士生導(dǎo)師。

研究方向：天然藥物化學(xué)（中藥化學(xué)）。

簡介：2015年5月作為高層次人才從中國科學(xué)院昆明植物研究所引進到中國藥科大學(xué)，現(xiàn)任中國藥科大學(xué)中藥學(xué)院副院長。國家杰出青年基金獲得者，享受國務(wù)院政府特殊津貼，中國科學(xué)院“百人計劃”和王寬誠西部學(xué)者突出貢獻獎獲得者，云南省中青年學(xué)術(shù)帶頭人和“三八”紅旗手。中國植物學(xué)會理事及其植物化學(xué)和資源學(xué)專業(yè)委員會主任委員，中國化學(xué)會化學(xué)生物學(xué)專業(yè)委員會和女化學(xué)工作者委員會委員，世界中醫(yī)藥學(xué)會聯(lián)合會中藥分析專業(yè)委員會和中藥化學(xué)專業(yè)委員會委員。在國內(nèi)外學(xué)術(shù)會議上作邀請報告70多次，主辦大型國內(nèi)或國際學(xué)術(shù)會議4次，Chemical Reviews、《中國天然藥物》等30多種國內(nèi)外雜志審稿人或編委，國家、云南省、中科院等項目評審專家。培養(yǎng)及聯(lián)合培養(yǎng)的研究生和博士后80余名，包括美國、澳大利亞、香港、尼日利亞、喀麥隆的國外研究生和博士后12名，與國內(nèi)外20多個實驗室建立了廣泛友好的實質(zhì)性合作關(guān)系。

學(xué)習(xí)工作經(jīng)歷：1984年學(xué)士畢業(yè)于貴陽醫(yī)學(xué)院藥學(xué)系，1990年碩士畢業(yè)于中國藥科大學(xué)天然藥物化學(xué)專業(yè)，1993年博士畢業(yè)于中國藥科大學(xué)天然藥物化學(xué)專業(yè)。1984-1987年貴陽醫(yī)學(xué)院藥學(xué)系教師，1993-1995年中國科學(xué)院昆明植物研究所植物化學(xué)博士后，1996-2015年中國科學(xué)院昆明植物研究所植物化學(xué)與西部植物資源持續(xù)利用國家重點實驗室研究組長、副研究員和研究員，2015年至今中國藥科大學(xué)教授。1996、1998、2006、2008年先后到德國BAYER藥物研究所、美國NCI、澳大利亞昆士蘭大學(xué)和美國威斯康星大學(xué)從事合作研究。

研究領(lǐng)域：主要從事天然藥物化學(xué)（中藥化學(xué)）研究，特別是植物環(huán)肽的資源、化學(xué)、生物學(xué)、化學(xué)生物學(xué)和新藥研究，目前主要集中在含環(huán)肽藥典中藥物質(zhì)基礎(chǔ)及功效成分、抗腫瘤和免疫抑制新藥研究、止咳中藥。研究工作涉及天然藥物化學(xué)（中藥化學(xué)）、藥用植物資源、藥物篩選與作用機制、藥物設(shè)計與有機合作、化學(xué)生物學(xué)、新藥研發(fā)等。

研究成果：在Chemical Reviews, Science, Organic Letters, British Journal of Pharmacology, Journal of Natural Products, Phytochemistry等國內(nèi)外雜志上發(fā)表論文270多篇，其中SCI論文160多篇，參編專著章節(jié)10個，申請或授權(quán)專利16項，獲得云南省自然科學(xué)一等獎1項。先后承擔國家自然科學(xué)基金、973、新藥創(chuàng)制重大專項、中科院項目、云南省自然科學(xué)基金、國際合作等項目40多個。代表性工作是植物環(huán)肽、復(fù)雜配糖體和抗腫瘤活性研究等。在植物環(huán)肽研究方面取得了系統(tǒng)的創(chuàng)新性研究成果，獲得2006年度云南省自然科學(xué)一等獎，應(yīng)邀在化學(xué)學(xué)科影響因子第一的ChemicalReviews（2006,106:840）發(fā)表論文，該文入選2008年度首屆中國百篇最具影響優(yōu)秀國際學(xué)術(shù)論文。

電子郵箱：nhtan@mail.kib.ac.cn。

近十年來發(fā)表的代表性學(xué)術(shù)論文：

1.Clara Bik-San Lau*, Grace Gar-Lee Yue, Kwok-Pui Fung, Ning-Hua Tan, Ping-Chung Leung. The potential roles of Chinese herbal medicines in cancer management. Science, 2015, 347 (6219 suppl): S45-S47
2.Hoi-Wing Leung, Zhe Wang, Grace Gar-Lee Yue, Si-Meng Zhao, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Clara Bik-San Lau*, Ning-Hua Tan*. Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells probably via PI3K/AKT and NF-kBsignaling pathways. BBA Molecular Cell Research, 2015, 1853: 1827-1840
3.Zeng-Ying Qiao,Di Zhang,Chun-Yuan Hou, Si-Meng Zhao,Ya Liu, Yu-Juan Gao, Ning-Hua Tan, * Hao Wang*. A PH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy. Journal of Materials Chemistry B, 2015, 3: 4514-4523
4.Na-Na Liu, Si-Meng Zhao, Jing-Feng Zhao, Guang-Zhi Zeng, Ning-Hua Tan*, Jian-Ping Liu*. Synthesis and conformation studies of rubiyunnanin B analogs. Tetrahedron, 2014, 70(37): 6630-6640
5.Mao-Bo Huang, Si-Meng Zhao, Guang-Zhi Zeng*, Bin Kuang, Xiao-Qiang Chen, Ning-Hua Tan*. Rubischumanins A-C, three cytotoxic cyclopeptides from Rubia schumanniana. Tetrahedron, 2014, 70: 7627-7631
6.Si-Meng Zhao, Zhe Wang, Guang-Zhi Zeng*, Wei-Wu Song, Xiao-Qiang Chen, Ning-Hua Tan*. Novel cytotoxic naphthohydroquinone dimers from Rubia alata. Organic Letters, 2014, 16: 5576-5579
7.Wen-Yan Xu, Bo Wang, Yuan Lin*, Yu-Hua Li, Zhao-Hui Su, Wen-Jun He, Ning-Hua Tan*, Qian Wang. Emulsion stabilized by mini cyclic proteins for bioactive compounds delivery. RSC Advances, 2014, 4: 48000-48003
8.Lai Yue Chan, Wen-Jun He, Ning-Hua Tan*, Guang-Zhi Zeng, David J. Craik, Norelle L. Daly*. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides, 2013, 39: 29-35
9.Grace G.L. Yue, Ben C.L. Chan, Hin-Fai Kwok, Yuk-Lau Wong, Hoi-Wing Leung， Chang-Jiu Ji, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara B.S. Lau*. Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica. European Journal of Medicinal Chemistry, 2013, 59: 243-252
10.Xian-Ying Fang, Wei Chen, Jun-Ting Fan, Ran Song, Lu Wang, Yan-Hong Gu, Guang-Zhi Zeng, Yan Shen, Xue-Feng Wu, Ning-Hua Tan*, Yang Sun*, Qiang Xu*. Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. Toxicology and Applied Pharmacology, 2013, 267: 95-103
11.Hui-Min Xu, Hua Yi, Wen-Bing Zhou, Wen-Jun He,Guang-Zhi Zeng, Wen-Yan Xu, Ning-Hua Tan*. Tataricins A-B, two novel cyclotetrapeptides from Aster tataricus, and their absolute configuration assignment. Tetrahedron Letters, 2013, 54: 1380-1383
12.Hui-Min Xu, Guang-Zhi Zeng, Wen-Bing Zhou, Wen-Jun He, Ning-Hua Tan*. Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus. Tetrahedron, 2013, 69: 7964-7969
13.Wen-Jun He, Lai Yue Chan, Richard J. Clark, Jun Tang, Guang-Zhi Zeng, Octavio L. Franco, Cinzia Cantacessi, David J. Craik, Norelle L. Daly*, Ning-Hua Tan*. Novel inhibitor cyctine knot peptides from Momordica charantia. PLOS ONE, 2013, 8(10): e75334
14.Wen-Jun He, Zhao-Hui Fu, Guang-Zhi Zeng, Yu-Mei Zhang*, Hong-Jing Han, He Yan, Chang-Jiu Ji, Hong-Biao Chu, Ning-Hua Tan*. Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathaya argyrophylla. Phytochemistry, 2012, 83：63-69
15.Wen-Yan Xu, Hong-Tao Zhu, Ning-Hua Tan*, Jun Tang, Ying-Jun Zhang, Ron L. Cerny, Liangcheng Du*. Biosynthetic studies of plant cyclopeptide heterophyllin B from the Chinese medicinal plant Pseudostellaria heterophylla. Plant Cell, Tissue & Organ Culture, 2012, 108: 137-14
16.Jun-Ju Xu, Chang-Jiu Ji, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Inhibition of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 1660-1663
17.Chang-Jiu Ji, Guang-Zhi Zeng, Jing Han, Wen-Jun He, Yu-Mei Zhang, Ning-Hua Tan*. Zizimauritic acids A-C, three novel nortriterpenes isolated from Ziziphus mauritiana. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 6377-6380
18.Jing Han, Chang-Jiu Ji, Wen-Jun He, Yu Shen, Ying Leng, Wen-Yan Xu, Jun-Ting Fan, Guang-Zhi Zeng, Ling-Dong Kong, Ning-Hua Tan*. Cyclopeptide alkaloids from Ziziphus apetala. Journal of Natural Products, 2011, 74: 2571-2575
19.Jun-Ting Fan, Bin Kuang, Guang-Zhi Zeng, Si-Meng Zhao, Chang-Jiu Ji, Yu-Mei Zhang, Ning-Hua Tan*. Biologically active arborinane-type triterpenoids and anthraquinones from Rubia yunnanensis. Journal of Natural Products, 2011, 74: 2069-2080
20.Grace GL Yue, Jun-Ting Fan, Julia KM Lee, Guang-Zhi Zeng, Tina WF Ho, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara BS Lau*. Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells. British Journal of Pharmacology, 2011, 164: 1883-1898
21.Yan Shen, Qiong Luo, Hui-Min Xu, Gang-Yuan Gong, Xiao-Bin Zhou, Yang Sun, Xue-Feng Wu, Wen Liu, Guang-Zhi Zeng, Ning-Hua Tan*, Qiang Xu*. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis. Biochemical Pharmacology, 2011, 82: 260-268
22.Yi-Shan Chen, Xu-Lin Pan, He Yan, Ning-Hua Tan*. Multiple hydrogen-bonding interactions between macrocyclic triurea and F-, Cl-, Br-, I- and NO3-: A theoretical investigation. Physical Chemistry Chemical Physics, 2011, 13(16): 7384-7395
23.Jun-Ting Fan, Yi-Shan Chen, Wen-Yan Xu, Liangcheng Du, Guang-Zhi Zeng, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Rubiyunnanin A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters, 2010, 51: 6810-6813
24.Jun-Ting Fan, Jia Su, Yan-Min Peng, Yan Li, Jia Li, Yu-Bo Zhou, Guang-Zhi Zeng, He Yan, Ning-Hua Tan*. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kB activation. Bioorganic & Medicinal Chemistry, 2010, 18: 8226-8234
25.Jun Tang, Conan K. Wang, Xu-Lin Pan, He Yan, Guang-Zhi Zeng, Wen-Yan Xu, Wen-Jun He, Norelle L. Daly, David J. Craik*, Ning-Hua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
26.He Yan, Xu-Lin Pan, Ning-Hua Tan*, Jun-Ting Fan, Guang-Zhi Zeng, Hong-Jin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432
27.Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T., Hajdu, J., Bohlin, L., Claeson, P., Goransson, U., Rosengren, K. J., Tang, J., Tan, N. H., Craik, D. J*. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 2009, 284(16): 10672-10683
28.Wen-Yan Xu, Jun Tang, Chang-Jiu Ji, Wen-Jun He, Ning-Hua Tan*. Application of a TLC chemical method to detection of cyclotides in plants. Chinese Science Bulletin, 2008, 53(11): 1671-1674
29.Yu-Mei Zhang, Ning-Hua Tan*, Yang Lu, Ying Chang, Rui-Rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9: 4579-4581
30.Ning-Hua Tan* and Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106: 840-895