江南大學

性別：男
出生年月：1979年5月4日
職稱、職務：教授
電話：
電子郵箱：fujita@jiangnan.edu.cn
【學術簡介】

教育背景：
2004-2006日本筑波大學生命環境科學研究科獲博士學位
2002-2004日本筑波大學生命環境科學研究科獲碩士學位
1998-2002日本筑波大學第二學群生物資源學類獲學士學位
工作經歷：
2014-現在江南大學生物工程學院教授
2012-2014日本大阪大學微生物病研究所助理教授
2008-2012日本大阪大學微生物病研究所特任助理教授
2007-2008日本大阪大學微生物病研究所博士后
2006-2007瑞士日內瓦大學生物化學學院博士后
2006-2006日本產業技術綜合研究所糖鎖研究中心博士后
【研究領域】

多年來，藤田盛久博士致力于細胞分子生物學和生物化學的研究，尤其是糖生物學和分子遺傳學領域。特別是他在蛋白質糖脂翻譯后修飾術語也叫做GPI錨定化的生理功能研究中的突出貢獻。他鑒定出并分析了GPI錨結構重構中的關鍵基因。目前，他把目標放在具有生物學和醫學意義的重要糖蛋白胞內轉運過程的研究。為了深入了解該過程，運用遺傳學方法，細胞生物學和生物化學等技術綜合的在動物細胞和酵母細胞中開展研究。
【主要論著】（著作和論文）

OriginalPapers
１.Theiler,R.,Fujita,M.,Nagae,M.,Yamaguchi,Y.,Maeda,Y.,andKinoshita,T.:
Theα-HelicalRegioninp24γ2Subunitofp24ProteinCargoReceptorIsPivotalfortheRecognitionandTransportofGlycosylphosphatidylinositol-anchoredProteins.
J.Biol.Chem.,289:16835-16843(2014)
２.Hirata,T.,Fujita,M.,Kanazawa,N.,Murakami,Y.,Maeda,Y.,andKinoshita,T.:
GlycosylphosphatidylinositolmannosyltransferaseIIistherate-limitingenzymeinglycosylphosphatidylinositolbiosynthesisunderlimiteddolichol-phosphatemannoseavailability.
J.Biochem.,154:257-264(2013)
３.Kanzawa,N.,Shimozawa,N.,Wanders,R.J.,Ikeda,K.,Murakami,Y.,Waterham,H.R.,Mukai,S.,Fujita,M.,Maeda,Y.,Taguchi,R.,Fujiki,Y.,andKinoshita,T.:
DefectivelipidremodelingofGPIanchorsinperoxisomaldisorders,Zellwegersyndrome,andrhizomelicchondrodysplasiapunctata.
J.LipidRes.,53:653-663(2012)
４.Fujita,M.,Watanabe,R.,Jaensch,N.,Romanova-Michaelides,M.,Satoh,T.,Kato,M.,Riezman,H.,Yamaguchi,Y.,Maeda,Y.,andKinoshita,T.:
SortingofGPI-anchoredproteinsintoERexitsitesbyp24proteinsisdependentonremodeledGPI.,
J.CellBiol.,194:61-75(2011)
５.Nakano,Y.,Fujita,M.,Ogino,K.,Kinoshita,T.,Oda,Y.,andHirata,H.:
BiogenesisofGPI-anchoredproteinsisessentialforsurfaceexpressionofsodiumchannelsinzebrafishRohon-Beardneuronstorespondtomechanosensorystimulation.,
Development,137:1689-1698　(2010)
６.Adachi,A.,Kano,F.,Tsuboi,T.,Fujita,M.,Maeda,Y.,andMurata,M.:
Golgi-associatedGSK3{beta}regulatesthesortingprocessofpost-Golgimembranetrafficking.,
J.CellSci.,123:3215-3225　(2010)
７.Fujita,M.,Maeda,Y.,Ra,M.,Yamaguchi,Y.,Taguchi,R.,andKinoshita,T.:
GPIglycanremodelingbyPGAP5regulatestransportofGPI-anchoredproteinsfromtheendoplasmicreticulumtotheGolgi.,
Cell,139:352-365(2009)
８.Hirayama,H.,Fujita,M.,Yoko-o,Y.,andJigami,Y.:
O-mannosylationisrequiredfordegradationoftheendoplasmicreticulum-associateddegradationsubstrateGas1*pviatheubiquitin/proteasomepathwayinSaccharomycescerevisiae.,
J.Biochem.,143(4):555-67(2008)
９.Umemura,M.,Fujita,M.,Yoko-o,Y.,Fukamizu,A.,andJigami,Y.:
SaccharomycescerevisiaeCWH43isinvolvedintheremodelingofthelipidmoietyofGPIanchorstoceramides.,
Mol.Biol.Cell,18(11):4304-16(2007)
１０.Maeda,Y.,Tashima,Y.,Houjou,T.,Fujita,M.,Yoko-o,T.,Jigami,Y.,Taguchi,R.,andKinoshita,T.:
FattyacidremodelingofGPI-anchoredproteinsisrequiredfortheirraftassociation.,
Mol.Biol.Cell,18(4):1497-506(2007)
１１.Fujita,M.,Umemura,M.,Yoko-o,T.,andJigami,Y.:
PER1isrequiredforGPI-phospholipaseA2activityandinvolvedinlipidremodelingofGPI-anchoredproteins.,
Mol.Biol.Cell,17(12):5253-64(2006)
１２.Fujita,M.,Yoko-o,T.,andJigami,Y.:
InositoldeacylationbyBst1pisrequiredforthequalitycontrolofglycosylphosphatidylinositol-anchoredproteins.,
Mol.Biol.Cell,17(2):834-50(2006)
１３.Fujita,M.,Yoko-o,T.,Okamoto,M.,andJigami,Y.:
GPI7involvedinglycosylphosphatidylinositolbiosynthesisisessentialforyeastcellseparation.,
J.Biol.Chem.,279(50):51869-79(2004)
ReviewsandBooks
１.Kinoshita,T.,Maeda,Y.andFujita,M.:
Transportofglycosylphosphatidylinositol-anchoredproteinsfromtheendoplasmicreticulum.
Biochim.Biophys.Acta–Mol.CellRes.,inpress(2013)
２.Fujita,M.:
PotentialRolesofGPI-AnchorRemodelinginProteinTraffickingandRaftAssociationinMammalianCells,
TrendsGlycosci.Glycotech.,24:244-257(2012)
３.Fujita,M.*andKinoshita,T.(*correspondingauthor):
GPI-anchorremodeling:PotentialfunctionsofGPI-anchorsinintracellulartraffickingandmembranedynamics.,
Biochim.Biophys.Acta,1821(8):1050-1058(2012)
４.Fujita,M.andKinoshita,T.:
StructuralremodelingofGPIanchorsduringbiosynthesisandafterattachmenttoproteins.,
FEBSLett.,584(9):1670-1677(2010)
５.Maeda,Y.,Fujita,M.,andKinoshita,T.:
GPI-Anchor:UpdateforBiosynthesisandRemodeling,
TrendsGlycosci.Glycotech.,22:182-193(2010)
６.Kinoshita,T.andFujita,M.:
OverviewofGPIbiosynthesis,
TheEnzymes,AcademicPress,26:1-30(2009)
７.Kinoshita,T.,Fujita,M.,andMaeda,Y.:
Biosynthesis,remodellingandfunctionsofmammalianGPI-anchoredproteins:recentprogress.,
J.Biochem.,144(3):287-94(2008)
８.Fujita,M.andJigami,Y.:
LipidremodelingofGPI-anchoredproteinsanditsfunction.,
Biochim.Biophys.Acta,1780(3):410-20(2008)
【科研項目】

2014年江蘇省自然科學基金青年基金
【科研成果及獎勵】

【榮譽與獎勵】

2012　YoungInvestigatorAwardofTheJapaneseBiochemicalSociety
2012　YoungInvestigatorAwardofTheJapaneseSocietyofCarbohydrateResearch
【在讀碩、博士人數】

碩士3名
【已畢業碩、博士人數】