華中農業大學

個人概況：

周 洋，女

農學博士，碩士生導師，副教授；

水生動物醫學系，水產學院，華中農業大學。

E-mail:  zhouyang@mail.hzau.edu.cn，zhouyang8728@gmail.com

通信：湖北省武漢市洪山區獅子山街1號，華中農業大學水產學院，郵編：430070

研究興趣：

1.水生動物細菌性病原致病機制；

2.水生動物細菌性病原疫苗；

3.細菌耐藥性機制。

教育背景：

2005/09-2009/07華中農業大學，生命科學技術學院，生物技術理科基地，學士

2012/05-2013/03 Montana State University-Department of Immunology and Infectious Diseases，聯合培養博士生

2008/09-2013/06 華中農業大學，動物醫學院，預防獸醫專業，博士

工作經歷：

2013/10-2015/10 華中農業大學，水產學院，博士后

2015/12-2017/05 University of Florida, Postdoctoral Associate

2015/10-至今     華中農業大學，水產學院，副教授

主持科研項目：

國家自然科學基金面上項目（31772889），嗜水氣單胞菌CodRS雙組份系統致病機制研究，2018/01-2021/12

國家自然科學基金青年項目（31402341），水氣單胞菌分泌型核酸酶介導逃逸團頭魴中性粒細胞胞外網捕殺的機制研究，2015/01-2017/12

中國博士后科學基金特別資助（2015T80819），團頭魴巨噬細胞胞外網性質研究，2015/09-2018/08

華中農業大學自主科技創新基金（2662016QD010），鯉科魚類巨噬細胞胞外網研究，2016/01-2019/01

代表性論文：

1. Yang Zhou#, Xingxing Dong#, Zhiwei Li#, Geng Zou, Li Lin, Xiaohong Wang, Huanchun Chen, Robin B. Gasser, Jinquan Li*. Predominance of Streptococcus suis ST1 and ST7 in human cases in China, and detection of a novel sequence type, ST658. Virulence,2017, 8(6):1031-1035. (IF=5.418，JCR 一區)

2. Yachan Ji, Jinquan Li, Zhendong Qin, Aihua Li, Zemao Gu, Xiaoling Liu, Li Lin, Yang Zhou*. Contribution of nuclease to the pathogenesis of Aeromonas hydrophila. Virulence, 2015, 6(5): 515-22 (IF=5.418，JCR 一區)

3. Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaoling Liu, Yang Zhou*, Li Lin*. Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (Danio rerio) during Infection with Aeromonas sobria. Int J Mol Sci, 2015, 16(5): 10997-1012 (IF= 3.257)

4. Yang Zhou#, Yan Wang#, Limei Deng, Chengkun Zheng, Fangyan Yuan, Huanchun Chen, Weicheng Bei, Jinquan Li*. Evaluation of the protective efficacy of four novel identified membrane associated proteins of Streptococcus suis serotype 2. Vaccine, 2015, 33(19): 2254-60 （IF= 3.624 JCR一區）

5. Xiaoling Liu, Xiaocheng Tang, Li Wang, Jie Li, Hong Wang, Shun Wei, Rui Fang, Wei Ji, Gailing Yuan, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, Yang Zhou*, Li Lin*. Molecular cloning and expression analysis of mannose receptor in blunt snout bream (Megalobrama amblycephala). Molecular Biology Reports, 2014, 41(7): 4601-11 (IF= 2.024)

6 Yang Zhou, Tracey S Hanks, Wenchao Feng, Jinquan Li, Guanghui Liu, Mengyao Liu, Benfang Lei*, The sagA/pel locus does not regulate the expression of the M protein of the M1T1 lineage of group A Streptococcus, Virulence, 2013, 4(8): 698-706  (IF=5.418 JCR 一區)

7. Yang Zhou, Lu Li, Zhaohui Chen, Hong Yuan, Huanchun Chen, Rui Zhou*, Adhesion protein ApfA of Actinobacillus pleuropneumoniae is required for pathogenesis and is a potential target for vaccine development, Clin Vaccine Immunol, 2013, 20(2): 287-94  (IF= 2.425)

8. Xingxing Dong, Zhendong Qin, Xianqin Hu, Jiangfeng Lan, Gailing Yuan, Muhammad Asim, Yang Zhou, Taoshan Ai, Jie Mei, Li Lin*. Molecular cloning and functional characterization of cyclophilin A in yellow catfish (Pelteobagrus fulvidraco). Fish Shellfish Immunol, 2015, 45(2): 422-430

9. Wenwen Wang, Muhammad Asim, Lizhu Yi, Abeer M. Hegazy, Xianqin Hu, Yang Zhou, Taoshan Ai, Li Lin*. Abortive infection of snakehead fish vesiculovirus in ZF4 cells was associated with the RLRs pathway activation by viral replicative intermediates. Int J Mol Sci, 2015, 16(3):6235-50

10. Xiaoheng Zhao, Lichun Liu, Abeer M. Hegazy, Hong Wang, Jie Li, Feifei Zheng, Yang Zhou, Weimin Wang, Jun Li, Xiaoling Liu*, Li Lin*. Mannose receptor mediated phagocytosis of bacteria in macrophages of blunt snout bream (Megalobrama amblycephala) in a Ca2+-dependent manner. Fish and Shellfish Immunology, 2015, 43(2): 357-63

11. Liyue Liu, Bibo Zhu, Shusheng Wu, Li Lin, Guangxin Liu, Yang Zhou, Weimin Wang, Muhammad Asim, Junfa Yuan, Lijuan Li, Min Wang, Yuannan Lu, Huanling Wang, Jianbo Cao, Xueqin Liu*. Spring Viremia of Carp Virus Induces Autophagy for Necessary Viral Replication. Cell Microbiol, 2015, 17(4): 595-605

12. Weidong Zhou, Yulei Zhang, Yi Wen, Wei Ji, Yang Zhou, Yachan Ji, Xiaoling Liu, Weimin Wang, Muhammad Asim, Xufang Liang*, Taoshan Ai*, Li Lin*. Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses. Fish and Shellfish Immunology, 2015, 43(1): 111-9

13.Wenjun Xu, Zhendong Qin, Hui Shi, Jiangfeng Nan, Yang Zhou, Xiaoling Liu, Jianjun Xie, Genshen Wang, Weimin Wang, Muhammad Asim, Lingbing Zeng, Li Lin*. Mass mortality associated with a viral-induced anaemia in cage-reared large yellow croaker, Larimichthys crocea (Richardson). Journal of Fish Diseases, 2015, 38(5): 499-502

14. Xiaodan Liu, Jiannan Huang, Shaoping Weng, Xiaoqin Hu, Wenjie Chen, Zhendong Qin, Xingxing Dong, Xiaoling Liu, Yang Zhou, Muhammad Asim, Weimin Wang, Jianguo He, Li Lin*. Infections of nervous necrosis virus in wild and cage-reared marine fish from South China Sea with unexpected wide host ranges. J Fish Dis, 2015, 38(6): 533-40

15. Lichun Liu, Yang Zhou, Xiaoheng Zhao, Hong Wang, Li Wang, Gailing Yuan, Muhammad Asim, Weimin Wang, Lingbing Zeng, Xiaoling Liu, Li Lin. Oligochitosan stimulated phagocytic activity of macrophages from blunt snout bream (Megalobrama amblycephala) associated with respiratory burst coupled with nitric oxide production. Dev Comp Immunol, 2014, 47(1): 17-24

16. Jinquan Li, Guanghui Liu, Wenchao Feng, Yang Zhou, Mengyao Liu, James A. Wiley, Benfang Lei*, Neutrophils select hypervirulent CovRS mutants of M1T1 group A Streptococcus during subcutaneous infection of mice, Infect Immun, 2014, 82(4): 1579-90

17. Li Wang, Lichun Liu, Yang Zhou, Xiaoheng Zhao, Mingjun Xi, Shun Wei, Rui Fang, Wei Ji, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, X Liu*, L Lin*, Molecular cloning and expression analysis of mannose receptor C type 1 in grass carp (Ctenopharyngodonidella), Dev Comp Immunol, 2014, 43(1): 54-8

18. Jinquan Li, Hui Zhu, Wenchao Feng, Mengyao Liu, Yingli Song, Xiaolan Zhang, Yang Zhou, Weicheng Bei, Benfang Lei*, Regulation of inhibition of neutrophil infiltration by two-component regulatory system CovRS in subcutaneous mouse infection with Group A Streptococcus, Infect Immun, 2013, 81(3): 974-83

19. Lu Li, Zhuofei Xu, Yang Zhou, Lili Sun, Ziduo Liu, Huanchun Chen, Rui Zhou*,Global effects of catecholamines on Actinobacillus pleuropneumoniae gene expression, PLoS ONE, 2012, 7(2): e31121

20. Jinquan Li, Jin Xia, Chen Tan, Yang Zhou, Yan Wang, Chengkun Zheng, Huanchun Chen, Weicheng Bei*, Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2, Vaccine, 2011, 29(38): 6514-9

21. Lu Li, Zhuofei Xu, Yang Zhou, Tingting Li, Lili Sun, Huanchun Chen, Rui Zhou*, Analysis on Actinobacillus pleuropneumoniae LuxS regulated genes reveals pleiotropic roles of LuxS/AI-2 on biofilm formation, adhesion ability and iron metabolism, Microb Pathogenesis, 2011, 50(6): 293-302

22. Jinquan Li, Chen Tan, Yang Zhou, Shulin Fu, Linlin Hu, Jin Hu, Huanchun Chen, Weicheng Bei*, The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2,Vet Microbiol, 2011, 148(1): 99-104