湖南師范大學

湖南師范大學生命科學學院生物化學與分子生物學研究生導師趙宇介紹如下：

姓       名：趙宇，教授，博士導師     

學       科：生物化學與分子生物學     

研究方向：蛋白質修飾與人類疾病

電       話：18607426382 

電子郵件：smile_zhao@hotmail.com

通訊地址：湖南長沙岳麓區湖南師范大學生命科學學院, 410081

個人簡介

2005年獲中國科學院研究生院博士學位，畢業后赴美學習、工作十余年，先后在美國福克斯切斯癌癥中心(FCCC)和俄克拉荷馬大學醫學院(OUHSC)從事博士后研究，2012-2017年在圣路易斯華盛頓大學醫學院(WUSTL)從事蛋白質功能與生物醫學研究工作，2017年回國受聘為湖南師范大學生命科學學院教授、博士生導師、"瀟湘學者"特聘教授，致力于基礎科學與疾病病理的交叉研究，研究涉及泛素化、磷酸化等蛋白質修飾的機制，及其與DNA損傷、腫瘤、糖尿病和炎癥等疾病的關聯，研究論文發表在Nature、Molecular Cell、EMBO J和Diabetes等國際重要SCI學術期刊。     

代表性著作(IF為2017年影響因子)

1. Zhao, Yu,Mudge MC, Soll JM, Rodrigues RB, Byrum, AK, Schwarzkopf EZ, Bradstreet TR, Gygi SP, Edelson BT, Mosammaparast N., OTUD4 is a phospho-activated K63 deubiquitinase that regulates MyD88-dependentsignaling. Molecular Cell. 2017 Dec (SCI一區, IF 14.7, accepted)     

2.Brickner JR, Soll JM, Lombardi PM, Vågbø CB,Mudge MC, OyeniranC, Rabe R,Jackson J, Sullender ME, Blazosky E,Byrum AK, Zhao Yu, Corbett MA, GéczJ, Field M, Vindigni A,Slupphaug G, Wolberger C, Mosammaparast N. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repairNature. 2017 Nov 16;551(7680):389-393 (SCI一區, IF 40.1)     

3. Zhao, Yu, Majid MC,SollJM,Brickner JR, Dango S, Mosammaparast N., Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. EMBO Journal.2015 Jun 12;34(12):1687-703. (SCI一區, IF 9.79)

4.Zhao, Yu,Brickner JR, Majid MC, Mosammaparast N., Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair. Trends Cell Biol.2014 Jul;24(7):426-34. (SCI一區, IF 15.33)     

5. Zhao, Yu, Wu J, Zhu H, Song P, Zou MH. Peroxynitrite-dependent zinc release and inactivation of guanosine 5'-triphosphate cyclohydrolase 1 instigate its ubiquitination in diabetes. Diabetes.2013 Dec;62(12):4247-56.(SCI一區, IF 8.68)     

6. Zhao, Yu,Zhu H, Zou MH. Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. PLoS One2012;7(9):e43306.(SCI, IF 2.8)     

7. Mosammaparast N, Kim H, Laurent B, Zhao, Yu, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y., The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol.2013 Nov 11;203(3):457-70. (SCI一區, IF 7.95)

8. Zhu H, Moriasi CM, Zhang M, Zhao, Yu, Zou MH. Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation. J Biol Chem.2013 Jun 7;288(23):16495-505. (SCI, IF 4.12)

9.  Zhao, Yu, Zhu, H.P.,Zou, M.H. 2012. Identification of a Ubiquitin-Binding Domain (UBD) in GTP cyclohydrolase 1. The FASEB Journal.2012; (Abstract) 26: 754.6. (SCI, IF 5.49)

10. Lake RJ, Geyko A, Hemashettar G, Z, Zhao, Yu, Fan HY. UV-Induced Association of the CSB Remodeling Protein with Chromatin Requires ATP-Dependent Relief of N-Terminal Autorepression. Molecular Cell. 2010; 37(2), 235-246. (SCI一區, IF 14.7)

11. Gu Y, Chen W, Zhao, Yu, Chen, L, Peng, T., Quantitative analysis of elevated serum Golgi protein-73 expression in patients with liver diseases. Ann ClinBiochem. 2009; 46(Pt 1), 38-43. (SCI, IF 2.02)

12. Liu J, Wu Q, Pi C, Zhao, Yu, Zhou M, Wang L, Chen S, Xu A., Isolation and characterization of a t-superfamily conotoxin from conuslitteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides. 2007; 28:2313-2319 (SCI, IF 2.61)

13. Pi, C., Liu, J., Peng, C., Liu, Y., Jiang, X., Zhao, Yu, Tang, S., Wang, L., Dong, M., Chen, S., Xu, A., Diversity and evolution of conotoxins based on gene expression profiling of Conuslitteratus. Genomics. 2006; 88(6), 809-819.  (SCI, IF 2.8)

14. Zhao, Yu,Jin, Y., Lee, W.H., Zhang, Y., Purification of a lysozyme from skin secretions of Bufoandrewsi. Comp. Biochem. Physiol. C ToxicolPharmacol. 2006; 142(1-2), 46-52. (SCI, IF 2.41)

15. Zhao, Yu,Jin, Y., Wei, S.S., Lee, W.H., Lai, R., Zhang, Y., Purification and characterization of an irreversible serine protease inhibitor from skin secretions of Bufoandrewsi.Toxicon.2005; 46(6), 635-640. (SCI, IF 1.92)     

16. Zhao, Yu,Jin, Y., Lee, W.H., Zhang, Y., Isolation and Preliminary Characterization of A 22-kDa Protein with Trypsin Inhibitory Activity from Toad Bufoandrewsi Skin. Toxicon. 2005; 46(3), 277-281. (SCI, IF 1.92)

17. Zhao, Yu,Jin, Y., Wang, J.H., Wang, R.R., Lee, W.H., Zheng, R.T., Zhang, Y., A novel heme-containing protein with anti-HIV-1 activity from skin secretions of Bufoandrewsi. Toxicon.2005; 46(6), 619-624. (SCI, IF 1.92)     

18. Lai, R., Zhao, Yu, Liu, H., Zhang, Y.J., Lee, W.H., Zhang, Y., Bioactive substance of amphibian skin and a study on protection and utilization of Chinese amphibian resources. Zoological Research. 2002; 23(1), 65-70.

19. 賴仞，趙宇，楊東明，查宏光，李文輝，張云, 六種常見兩棲類動物皮膚分泌物的生物活性比較. Zoological Research.2002; 23(2), 113-119.