重慶大學

梅虎：主要從事藥物設計、藥物基因組學、生物信息學等領域研究。先后在《PNAS》，《Scientific Reports》，《Toxicological Sciences》，《J Chem Inf Model》，《European Journal of Medicinal Chemistry》等國際期刊上發(fā)表發(fā)表SCI收錄論文60余篇，單篇最高引用90余次，累計引用310余次。申請發(fā)明專利5項，獲權2項。先后主持國家高技術發(fā)展研究計劃（“863”計劃）、國家自然科學基金等多項省部級以上科研項目；研究成果“肽定量構效關系研究與應用”獲教育部自然科學獎二等獎；曾獲重慶大學“優(yōu)秀青年教師”和“學生科技園丁”等榮譽稱號。指導本科生參加美國數(shù)學建模競賽獲二等獎和三等獎各一項；指導研究生獲得重慶市優(yōu)秀博士學位論文1人，重慶市優(yōu)秀碩士學位論文1人，重慶大學優(yōu)秀畢業(yè)研究生3人。現(xiàn)為《Journal of Medicinal Chemistry》，《Bioorganic & Medicinal Chemistry Letters》，《SCIENCE IN CHINA》，《CHINESE JOURNAL OF STRUCTURAL CHEMISTRY》等雜志審稿人。

近年來，主要進行基于結(jié)構的合理藥物設計、遺傳異質(zhì)性藥物毒副作用機理與個性化醫(yī)療等相關研究。歡迎藥學、生物學、化學等相關專業(yè)學生報考本學科方向研究生。

代表性論文目錄（2010~）：

1. Zhang ZH, Chen S, Mei H, Xuan JK, Guo XQ, Couch L, Dobrovolsky VN, Guo L, Mei N. 2015. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells.Scientific Reports5

2. Sun JY, Mei H. 2015. QSAR and molecular mechanism analysis of N-substituted oseltamivir derivatives as potent avian influenza H5N1 neuraminidase inhibitors.Chemometrics and Intelligent Laboratory Systems146: 485-93

3. Pan XC, Chao L, Qu SJ, Huang SH, Yang L, Mei H. 2015. An improved large-scale prediction model of CYP1A2 inhibitors by using combined fragment descriptors.Rsc Advances5: 84232-7

4. Liu T, Pan X, Chao L, Tan W, Qu S, Yang L, Wang B, Mei H. 2014. Subangstrom accuracy in pHLA-I modeling by Rosetta FlexPepDock refinement protocol.J Chem Inf Model54: 2233-42

5. Xie JG, Xu ZL, Zhou SB, Pan XC, Cai SX, Yang L, Mei H. 2013. The VHSE-Based Prediction of Proteasomal Cleavage Sites.Plos One8

6. Tan W, Mei H, Chao L, Liu TF, Pan XC, Shu M, Yang L. 2013. Combined QSAR and molecule docking studies on predicting P-glycoprotein inhibitors.Journal of Computer-Aided Molecular Design27: 1067-73

7. Tan QY, Wu JY, Li Y, Mei H, Zhao CJ, Zhang JQ. 2013. A supermolecular curcumin for enhanced antiproliferative and proapoptotic activities: molecular characteristics, computer modeling and in vivo pharmacokinetics.Nanotechnology24

8. Tan QY, Li Y, Wu JY, Mei H, Zhao CJ, Zhang JQ. 2012. An optimized molecular inclusion complex of diferuloylmethane: enhanced physical properties and biological activity.International Journal of Nanomedicine7: 5385-93

9. Sun J, Mei H. 2012. Docking and 3D-QSAR investigations of pyrrolidine derivatives as potent neuraminidase inhibitors.Chemical Biology & Drug Design79: 863-8

10. Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CAF, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. 2012. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.Proceedings of the National Academy of Sciences of the United States of America109: 9959-64

11. Li Y, Mei H, Wu Q, Zhang S, Fang J-L, Shi L, Guo L. 2011. Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1.Toxicological Sciences124: 388-99

12. Sun JY, Cai SX, Yan N, Mei H. 2010. Docking and 3D-QSAR studies of influenza neuraminidase inhibitors using three-dimensional holographic vector of atomic interaction field analysis.European Journal of Medicinal Chemistry45: 1008-14

13. Sun JY, Cai SX, Mei H, Li JA, Yan N, Wang Q, Lin ZH, Huo DQ. 2010. Molecular Docking and QSAR Studies on Substituted Acyl(thio)urea and Thiadiazolo [2,3-alpha] Pyrimidine Derivatives as Potent Inhibitors of Influenza Virus Neuraminidase.Chemical Biology & Drug Design76: 245-54