華中農(nóng)業(yè)大學(xué)

姓名：張青葉

性別：女

職稱：副教授

學(xué)位：博士

電話：027-87280877

郵箱：zqy@mail.hzau.edu.cn

工作單位：

華中農(nóng)業(yè)大學(xué)信息學(xué)院

研究方向：

蛋白質(zhì)結(jié)構(gòu)分析及藥物發(fā)現(xiàn)研究

教育經(jīng)歷：

2003/09-2008/06，華中師范大學(xué)，化學(xué)學(xué)院，碩博連讀

1999/09-2003/07，安慶師范學(xué)院，化學(xué)系，本科

主要職歷：

2014/07- 至今 華中農(nóng)業(yè)大學(xué)，信息學(xué)院，副教授

2011/01-2014/06，華中農(nóng)業(yè)大學(xué)，理學(xué)院，副教授

2010/10-2010/12，華中農(nóng)業(yè)大學(xué)，理學(xué)院，講師

2008/07-2010/09，華中農(nóng)業(yè)大學(xué)，生命科學(xué)技術(shù)學(xué)院，博士后

科研成果：

近年主持的科研項(xiàng)目：

1、博士后一等資助，項(xiàng)目名稱： 蘇云金芽胞桿菌YBT-1520的代謝網(wǎng)絡(luò)調(diào)控研究，起止年限：2008.08-2010.09

2、博士后特別資助，項(xiàng)目名稱：基于Glmu靶酶結(jié)構(gòu)的新型抑制劑先導(dǎo)化合物的合理設(shè)計(jì)與篩選，起止年限：2009.10-2011.06

3、國(guó)家自然科學(xué)基金，項(xiàng)目名稱：GlmU靶酶活性中心與其配體相互作用的機(jī)理及其抑制劑先導(dǎo)結(jié)構(gòu)的研究，起止年限：2010.01-2012.12

4、華中農(nóng)業(yè)大學(xué)培育專項(xiàng)，項(xiàng)目名稱：基于靶酶結(jié)構(gòu)的新型抑制劑結(jié)構(gòu)的優(yōu)化設(shè)計(jì)與合成，起止年限：2011.05-2012.12

近年發(fā)表的文章：

1、Jingnan Jin, Xiaojuan Qi, Dandan Yao, Bangqiang Mao, Jianhong Li, Qing Y. Zhang* and Changshui Chen*. Rational Design and Screening Study of Novel Lead Compound Based on Acetohydroxyacid Synthase Structure. Chem Biol Drug Des, 86, 316-324, 2014. (IF: 2.469)

2、Xia-Li Yue Hu Li Shuang-Shuang Liu Qing Y. Zhang* Jing-Jing Yao Fei-Yan Wang. N-Fluorinated phenyl-N’-pyrimidyl urea derivatives: Synthesis, biological evaluation and 3D-QSAR study. Chinese Chemical Letters. 25, 1069-1072, 2014. (IF: 1.178)

3、Jing Wang1, Qing Y. Zhang1, Zongqing Huang, Ziduo Liu∗ Directed evolution of a family 26 glycoside hydrolase: Endo- b -1,4-mannanase from Pantoea agglomerans A021. J of Biotechnology 167, 350-356, 2013. (IF: 3.183, the first two authors contributed equally)

4、Jun Min, Da Lin, Qing Y. Zhang*, Jibing Zhang, Ziniu Yu. Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU. Eur. J. Med. Chem. 53, 150-158, 2012. (IF: 3.499)

5、Jingnan Jin, Hongju Ma, Xiufang Cao, Shengzhen Xu, Jianhong Li, Qing Y. Zhang*, Changshui Chen. The discovery of the novel lead compound of N-nitroureas target on acetohydroxyacid synthase. Pestic. Biochem. Phys. 104, 218-223, 2012. (IF: 2.111)

6、Qing Y. Zhang, Chan Yu, Jun Min, Yan Wang, Jin He, Ziniu Yu*. Rational Questing for Potential Novel Inhibitors of FabK from Streptococcus pneumoniae by Combining FMO Calculation, CoMFA 3D-QSAR Modeling and Virtual Screening.J. Mol. Model. 17, 1483-1492, 2011. (IF: 1.871）

7、Jun Min, Xiaoli Zhang, Lei Wang, Xia Zou, Qing Y. Zhang*, Jin He*. Mutational analysis of the interaction between a potential inhibitor luteolin and enoyl-ACP reductase (FabI) from Salmonella enterica. J. Mol. Catal b-Enzym. 68, 174-180, 2011. (IF: 2.330)

8、Qing Y. Zhang, Ding Li, Yangliang Ren, Jie Zhang, Jian Wan, Pei Wei, Zhigang Chen, Deli Liu, Ziniu Yu. Structure-based Rational Screening of Novel Hit Compounds with Structural Diversity for Cytochrome P450 Sterol 14a-demethylase from Penicillium digitatum. J. Chem. Inf. Model. 50, 317-325, 2010. (IF: 3.822)

9、Jingjing Yao1, Qing Y. Zhang1, Jun Min, Jin He*, Ziniu Yu*. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Bioorg. Med. Chem. Lett. 20, 56-59, 2010. (IF: 2.661，the first two authors contributed equally)