河北大學

河北大學化學與環境科學學院研究生導師楊新健介紹如下：

一、學習和工作經歷

工作經歷：

2015/3-至今， 河北大學， 化學與環境科學學院

2013/04 - 2015/3，新加坡國立大學，博士后

教育經歷：

2007/9 - 2013/1，中國科學院長春應用化學研究所，無機化學專業，博士

2003/9 - 2007/6，河北大學，高分子材料與工程，學士

二、聯系方式

E-mail: jianxinyang123@163.com; xjyang321@hbu.edu.cn

郵 編：071002

地 址：河北省保定市五四東路180號

三、主要研究方向

納米醫學、化學生物學、生物傳感

四、主講課程

分析化學、基礎化學分析實驗

五、主持課題

1. 河北省第三批青年拔尖人才項目;

2. 靶向腫瘤細胞的DNAzyme納米載體的構建及其逆轉腫瘤多藥耐藥的研究，國家自然科學基金青年項目;

3. DNAzyme納米組裝體克服腫瘤熱耐受性用于提高光熱治療效果的研究;河北省自然科學基金杰青項目;

4. 近紅外光激活的刺激響應藥物釋放體系構建及其抗腫瘤研究，河北省自然科學基金面上項目;

5. 基于近紅外光響應、siRNA包覆的可控藥物釋放體系的構建，河北省教育廳項目;

六、代表性成果 (*代表通訊作者)

18.Wang Lei, Meng Tianjiao, Yu Guangshun, Wu Shasha, Sun Jingjing, Jia Huixian, Wang Huan*, Yang Xinjian*, Zhang Yufan*, A label-free electrochemical biosensor for ultra-sensitively detecting telomerase activity based on the enhanced catalytic currents of acetaminophen catalyzed by Au nanorods.

Biosensors and Bioelectronics, 2019, 124, 53-58.

17. Wang Lei, Meng Tianjiao, Liang Linna, Sun Jingjing, Wu Shasha, Wang Huan*, Yang Xinjian*, Zhang Yufan*, Fabrication of amine-functionalized metal-organic frameworks with embedded palladium nanoparticles for highly sensitive electrochemical detection of telomerase activity, Sensors and

Actuators B: Chemical, 2019, 278, 133-139.

16. Jin Yi, Liang Linna, Sun Xiaojing, Yu Guangshun, Chen Shizhu, Shi Shutang, Liu Huifang, Li Zhenhua, Ge Kun, Liu Dandan, Yang Xinjian*, Zhang Jinchao*, Deoxyribozyme-nanosponges for improved photothermal therapy by overcoming thermoresistance, NPG Asia Materials. 2018,10, 373-384.

15. Sun Xiaojing, Jin Yi, Wang Hao, Feng Na, Li Zhenhua, Liu Dandan, Ge Kun, Liu Huifang, Zhang Jinchao*, Yang Xinjian*, A NIR-light activated nanoplatform for sensitizing triple negative breast cancer against therapeutic resistance to enhance the treatment effect, Journal of Materials Chemistry B,

2018, 6, 6950-6956.

14. Jin Yi, Li Zhenhua, Liu Huifang, Chen Shizhu, Wang Feng, Wang Ling, Li Nan, Ge Kun, Yang Xinjian*, Liang Xing-Jie*, Zhang Jinchao*, Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy. NPG Asia Materials. 2017, 9, e365.

13. Dong Yali, Wang Ling, Wang Feng, Li Nan, Jin Yi, Zhang Jinchao*, Yang Xinjian*, An etching based fluorescent probe for sensitive detection of hydrogen sulfide in cells, Analyst, 2017, 142, 4703-4707.

12.Zhang Shaohan, Chen Shizhu, Gao Chunyue, Jin Yi, Jia Guang, Li Zhenhua, Liu Dandan, Liang Xingjie, Yang Xinjian* and Zhang Jinchao*, Apoptosis induced by NaYF4:Eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway. SCIENCE CHINA Chemistry, 2017, 60, 122-129.

11. Yang Xinjian, Gao Zhiqiang*, Enzyme-catalysed deposition of ultrathin silver shells on gold nanorods: a universal and highly efficient signal amplification strategy for translating immunoassay into a litmus-type test, Chemical Communications, 2015, 51, 6928-6931.

10.Yang Xinjian, Ren Yuqian, Gao Zhiqiang*, Silver/Gold Core-Shell Nanoprism-Based Plasmonic Nanoprobes for Highly Sensitive and Selective Detection of Hydrogen Sulfide, Chemistry - A European Journal, 2015, 21, 988-992.

9. Yang Xinjian, Yu Yuebo, Gao Zhiqiang*, A Highly Sensitive Plasmonic DNA Assay Based on Triangular Silver Nanoprism Etching, ACS Nano, 2014, 8, 4902-4907.

8. Yang Xinjian, Gao Zhiqiang*, Gold nanoparticle-based exonuclease III signal amplification for highly sensitive colorimetric detection of folate receptor, Nanoscale, 2014, 6, 3055-3058.

7. Yang Xinjian, Li Zhenhua, Ju Enguo, Ren Jinsong*, Qu Xiaogang*, Reduced Graphene Oxide Functionalized with a Luminescent Rare-Earth Complex for the Tracking and Photothermal Killing of Drug-Resistant Bacteria，Chemistry - A European Journal, 2014, 20, 394-398.

6. Yang Xinjian, Li Zhenhua, Li Meng, Ren Jinsong*, Qu Xiaogang*, Fluorescent Protein Capped Mesoporous Nanoparticles for Intracellular Drug Delivery and Imaging, Chemistry - A European Journal, 2013, 19, 15378-15383.

5. Yang Xinjian, Zhao Chuanqi, Ju Enguo, Ren Jinsong*, Qu Xiaogang*, Contrasting modulation of enzyme activity exhibited by graphene oxide and reduced grapheme, Chemical Communications, 2013, 49, 8611-8613.

4.Yang Xinjian, Liu Zhen, Li Zhenhua, Pu Fang, Ren Jinsong*, Qu Xiaogang*, Near-Infrared-Controlled, Targeted Hydrophobic Drug-Delivery System for Synergistic Cancer Therapy, Chemistry - A European Journal, 2013, 19, 10388-10394.

3.Yang Xinjian, Liu Xia, Liu Zhen, Pu Fang, Ren Jinsong*, Qu Xiaogang*, Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles, Advanced Materials, 2012, 24, 2890-2895.(封面文章)

2.Yang Xinjian, Pu Fang, Chen Cuie，Ren Jinsong*, Qu Xiaogang, An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay, Chemical Communications，2012,48, 11133-11135.

1. Yang Xinjian, Pu Fang, Ren Jinsong*, Qu Xiaogang, DNA-templated ensemble for label-free and real-time fluorescence turn-on detection of enzymatic/oxidative cleavage of single-stranded DNA, Chemical Communications, 2011, 47, 8133-8135.