北京大學

周田彥博士副教授碩士生導師

電話/傳真：(10)-82801717

電子信箱：tianyanzhou@bjmu.edu.cn

簡歷

分別于1992 年、1998 年在北京醫科大學藥學院獲得學士和碩士學位，98年留校至今一直在北京大學藥學院藥劑教研室工作，并于2006 年取得藥劑學博士學位。曾到香港理工大學（2002-2004）和美國奧克拉荷馬州立大學（2007-2008）作訪問研究。主持了北京大學藥學院青年啟動基金，留學回國人員啟動基金，國家自然科學基金面上項目，是北京大學創新藥物平臺代謝子平臺的主要成員之一。近年來獲得的獎勵主要包括北京大學醫學部優秀青年學者（2010），北京大學醫學部教學優秀獎（2010），北京大學第十屆青年教師教學演示（醫科類）競賽三等獎（2010），教育部“高等學校科學技術獎”自然科學二等獎（2006）等。擔任《中國藥學雜志》、《中國藥學》英文版、《Chinese Journal of Natural Medicine》 等學術期刊的評審，在國內外發表論文30余篇，編寫教材與專著6部。主講本科生《藥劑學》、 《生物藥劑學與藥物動力學》以及研究生《群體藥物動力學以及藥物動力學/藥效動力學模型化與仿真》等課程。
 
研究領域與興趣

基于機制的藥物動力學/藥效動力學鏈式模型

藥物代謝酶的調控機理及其應用

發表論文

1. Zhou,Tianyan; Chen, Yue; Huang, Chaoqun; Chen, Guangping. Caffeine induction of sulfotransferases in rat liver and intestine. Journal of Applied Toxicology, (2011)，accepted

2. Shang, Dewei; Wang, Xipei; Zhao, Xiutai; Huang, Fengming; Tian, Ganzhong; Lu, Wei* and Tianyan Zhou*. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. J Chromatogr B , (2011) accepted

3. Li,Liang; Li, Zaiquan; Deng,Chenhui; Ning, Miaoran; Li, Hanqing; Bi, Shanshan; Zhou, Tianyan* and Lu, Wei*. Mechanism-based Pharmacokinetic/Pharmacodynamic Model for CYP3A1/2 Induction by Dexamethasone in Rats. Acta Pharmacologica Sinica, (2011), accepted

4. Li, HanQing; Li, MengYao; Li, ZaiQuan; Li, Liang; Bi, ShanShan; Deng, ChenHui; Chen, Rui; Zhou,TianYan* and Lu, Wei*. New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines. Chinese Journal of Chemistry, (2011), 29(8), 1709-1714.

5. Huang, Chaoqun; Zhou,Tianyan; Chen, Yue; Sun, Teng; Zhang, Shunfen; Chen, Guangping. Estrogen-related receptor ERR-mediated downregulation of human hydroxysteroid sulfotransferase (SULT2A1) in Hep G2 cells. Chemico-Biological Interactions, (2011), 92, 264–271.

6. Huang, Chaoqun; Zhou, Tianyan; Chen, Yue; Zhang, Shunfen; Chen, Guangping. (-) epicatechin regulation of hydroxysteroid sulfotransferase STa (rSULT2A1) expression in female rat steroidogenic tissues.Journal of Pharmacology and Toxicology, (2011), 6(4), 349-360.

7. Zhou, Tianyan; Huang, Chaoqun; Chen, Yue; Shanbhag, Preeti; Chen, Guangping. Methamphetamine regulation of sulfotransferases in rat liver and brain. American Journal of Pharmacology and Toxicology, (2010), 5(3), 125-132.

8. Zhou, Tianyan; Li, Xinming; Ng, Magdeline Tao Tao; Wang, Yifan; Quek, Ngee Mien; Luo, Ji; Yuan, Weixing; Tan, Choon-Hong; Zeng, Huaqiang; Li, Tianhu. Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chemistry, (2009), 20(4), 644-647.

9. Zhou, Tianyan; Wang, Yifan; Li, Xinming; Zhang, Qiang; Li, Tianhu. Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. Bulletin of the Chemical Society of Japan, (2006), 79(8), 1300-1302.

10. Zhou, Tianyan; Chen, Guoshu; Wang, Yifan; Zhang, Qiang; Yang, Ming; Li, Tianhu.Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Research (2004), 32(21), e173/1-e173/9.