西安交通大學

擔任職務：

西安交通大學前沿科學技術研究院、西安交大第一附屬醫院骨骼關節疾病與治療研究中心主任、特聘教授

聯系方式：

陜西省西安市雁翔路99號西安交通大學曲江校區西一樓前沿科學技術研究院，710054

電話：029-83395043

E-mail: Qian_Chen@mail.xjtu.edu.cn 

研究方向：

骨骼發育和衰老，細胞外基質，軟骨和骨組織工程，軟骨和骨的機械調控，骨關節炎和其它關節退行性疾病的機制研究

背景資料：

陳遷教授長期以來致力于骨骼關節發育和衰老的疾病機理研究和治療，具有世界一流的研究水平，是分子生物學、轉化醫學和骨科領域的國際權威專家。1992年在Tufts大學醫學院獲得細胞分子和發育生物學博士學位。1992年至1994年間在哈佛大學/麻省總醫院完成博士后工作。自從2002年起，被聘為美國著名“常青藤”盟校之一的布朗大學終身教授，Michael G. Ehrlich MD特聘主任教授，時年38歲（為布朗大學醫學院歷史上最年輕的終身特聘教授）。自從2007年，主持建立了由美國國立衛生研究院（NIH）支持的杰出生物醫學研究中心（COBRE），并任主任和首席負責人。此研究中心是全美八十多個杰出生物醫學研究中心中，僅有的兩個研究骨骼關節的中心之一。作為國際骨科關節研究的領軍人物，在骨骼關節研究領域，校外研究經費在全美（美國和加拿大）排名第二。 2012年9月起擔任西安交通大學前沿醫學科學研究所所長兼骨骼關節疾病和治療研究中心主任。其研究領域包括軟骨病，關節炎，骨折愈合，細胞外基質及生物力學傳導的分子機制。在國際骨科和關節炎醫學領域具有重要影響力。已編撰發表“骨關節炎的診斷，治療和手術（Osteoarthritis: Diagnosis, Treatment and Surgery）”等專著，在國際學術期刊發表的多篇論文為分子生物學在骨科領域應用的奠基性研究。其論文被引用近2000余篇次，H-index為29（2014年04月29日數據）。

 其代表性成果包括：1）骨骼發育的分子生物學奠基性研究揭示軟骨內骨化的分子生物學機理；成功建立了一系列軟骨細胞分化的標志分子，比如骨膠原十號（type X collagen）和其他軟骨基質分子。這些奠基性工作發表在PNAS ，Development, JBC等世界著名刊物上，為骨骼發育領域奠定了分子生物學基礎。2）骨骼軟骨的生物力學信號分子傳導與機理的開創性研究；揭示和鑒別了多個骨骼中調控生物力學信號傳導的重要基因，并發表了一系列首創性文章。這些文章被大量引用（單篇引用多達200次）并廣泛影響生物力學研究的各個領域。3）軟骨發育不良和骨關節炎調控基因的開創性研究；鑒別和認定關節軟骨在發育或衰老的過程中，導致軟骨組織損傷和退化的重要基因。多項研究第一次揭示軟骨基質分子的基因編碼與這些疾病的重要關系，發表在JCB, MBC, Developmental Biology。4）骨骼和關節退化病理與治療轉化研究；開發新的診斷和治療骨骼關節損傷和退化疾�。ɡ�如骨關節炎）的方法。通過干擾分解代謝相關的細胞分子和趨化分子，研發了新型治療方法來抑制軟骨組織的損傷和退化。開發了動物模型來模擬軟骨損傷和退化疾病的的病理學特征。這些模型對于新藥和新治療方法的研發具有不可估量的作用，并發表在Arthritis & Rheumatism, JBC, JBMR. 其在生物醫學前沿的研究領域，作出突出貢獻并多達16次獲得美國和國際重要科技獎項，包括J.V. Satterfield 關節炎研究員獎 (美國關節炎研究基金會青年研究員最高獎)；美國國立衛生研究院獨立科學家獎；諾華基金會科學家獎（當年全世界唯一獲獎者）；Kappa Delta 青年研究家獎（全美骨科研究最高榮譽）。已授權美國和國際發明專利兩項。

代表論文:

Zhang Y, Chen Q.  Changes of matrilin forms during endochondral ossification: molecular basis of oligomeric assembly.  J Biol Chem, 275(42):32628-32634, 2000.  PMID: 10930403

Wu Q, Chen Q. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel   dependent transduction of matrix deformation signals. Exp Cell Res, 256, 383-391, 2000. PMID: 10772811

You J, Reilly G, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts.  J Biol Chem, 276(16): 13365-13371, 2001. PMID: 11278573

Wu Q, Zhang Y, Chen Q.  Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation.  J Biol Chem, 276(38): 35290-35296, 2001. PMID: 11466306

Zhen X, Wei L, Wu Q, Zhang Y, Chen Q.  Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathroid hormone.  J Biol Chem, 276(7): 4879-4885, 2001. PMID: 11098049

Kanbe K, Takagishi K, Chen Q.  Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4 (Reply to study of SDF-1 alpha synovial fluid in early rheumatoid arthritis).  Arthritis Rheum, 48:275-276, 2003.  PMID: 11817585

Phornphutkul C, Wu KY, Yang X, Chen Q, Gruppuso PA.  Insulin-like Growth Factor-I signaling is modified during chondrocyte differentiation. J Endocrinology, 183: 477-486, 2004. PMID: 15590974

van der Weyden L, Wei L, Luo J, Yang X, Birk DE, Adams DJ, Bradley A, Chen Q.  Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. Am J Pathol 169:515-27, 2006.  PMID: 16877353 / PMCID: PMC1698783

Wei L, Sun X, Wang Z, Chen Q. CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. Arthritis Res Ther 8(2):R37, 2006. PMID: 16469115 / PMCID: PMC1526592

Wei L, Sun X, Kanbe K, Wang Z, Sun C, Terek R, Chen Q.  Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1.  J  Rheumatol 33:1818-26, 2006.  PMID: 16960943

Lee M, Bier A, Nickish F, Eberson C, Ehrlich MG, Chen Q. Epiphysiodesis with infusion of stromal cell-derived factor-1 in rabbit growth plates. J Bone Joint Surg Am 89:102-133, 2007.  PMID: 17200317

Kanbe K, Yang X, Wei L, Sun, C, Chen Q.  Pericellular matrilins regulate activation of chondrocytes by cyclic load-induced matrix deformation, J Bone Miner Res 22:318-328, 2007.  PMID: 17129169

Phornphutkul C, Wu K, Auyeung V, Chen Q, Gruppuso P.  mTOR  signaling contributes to chondrocyte differentiation. Dev Dyn  237(3):702-12, 2008.  PMID: 18265001 / PMCID: PMC2768549

Namdari S, Wei L, Moore D, Chen, Q. Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage.  Arthritis Rheum 58:3520-29, 2008.  PMID: 18975318 / PMCID: 2774253

Pei M, Lou J, Chen Q.  Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage 16:1110-17, 2008. PMID: 18282772 / PMCID: 2596998

Phornphutkul C, Lee M, Voigt C, Ehrlich MG, Gruppuso P, Chen Q. The effect of rapamycin on bone growth in rabbits, J Orthop Res  27(9):1157-1161, 2009.  PMID: 19382193 / PMCID: PMC2894807

Sun XJ, Wei L, Chen Q, Terek RM. HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating Runx2 activity. J Biol Chem. 284(33): 21881-90, 2009.  PMID: 19509597 / PMCID: PMC2755912

Sun X, Wei L, Chen Q, Terek RM.  CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression. Mol Cancer 9:17, 2010.  PMID: 20102637 / PMCID: PMC2825244

Wei L, Fleming BF, Sun XJ, Teeple E, Wu W, Jay GD, Elsaid KA, Luo J, Machan JT, Chen Q. Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model. J Orthop Res 28:900-6, 2010.  PMID: 20108346 / PMCID: PMC2875364

Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, Terek R, Chen Q.  Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation.  Dev Biol 341:236-45, 2010.  PMID: 20206617 / PMCID: PMC2862458

Guan YJ, Yang X, Wei L, Chen Q. MiR-365: A mechano-sensitive microRNA stimulates chondrocyte differentiation through targeting Histone Deacetylase 4. FASEB J, 25(12):4457-66. Epub 2011 Aug 19, 2011, PMID:21856783/PMCID: PMC3236620

Guan Y, Chen Q, Yang X, Haines P, Pei M, Terek R, Wei X, Zhao T, Wei L.  Subcellular Relocation of Histone Deacetylase 4 Regulates Growth Plate Chondrocyte Differentiation through Ca2+/Calmodulin-Dependent Kinase IV.  American Journal of Physiology-Cell Physiology, 2012; 303(1):C33-40. PMID: 22442139

Zhao J, Xia W, Nie M, Zheng X, Wang Q, Wang X, Wang W, Ning Z, Huang W, Jiang Y, Li M, Wang O, Xing X, Sun Y, Luo L, He S, Yu W, Lin Q, Pei Y, Zhang F, Han Y, Tong Y, Che Y, Shen R, Hu Y, Zhou X, Chen Q, Xu L. A haplotype of MATN3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study. Bone. 2012 Apr;50(4):917-24. Epub 2012 Jan 16. PMID 22270056

Wei F, Zhou J, Wei X, Zhang J, Fleming BF, Terek R, Pei M, Chen Q, Liu T, Wei L. Activation of Indian Hedgehog Promotes Chondrocyte Hypertrophy and Upregulation of MMP-13 in Human Osteoarthritic Cartilage, Osteoarthritis & Cartilage, 2012;20(7):755-63. PMID: 224698532012

Li J, Huang J, Dai L, Yu D, Chen Q, Zhang X, Dai K. MiR-146a, an IL-1beta Responsive MicroRNA, Induces VEGF and Chondrocyte Apoptosis by Targeting Smad4, Arthritis Research & Therapy, 2012 14(2):R75. PMID:22507670

Desai HV, Voruganti IS, Jayasuriya C, Chen Q, Darling EM. Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells, 2012, Tissue Engineering Part A, 2012, Jul 28. [Epub ahead of print]. PMID:22840182

Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L. Genetic inhibition of FGFR1 in cartilage attenuates articular cartilage degeneration in adult mice. Arthritis Rheum. 2012 Jul 25. doi: 10.1002/art.34645. [Epub ahead of print] PMID: 22833219

Jayasuriya CT, Goldring MB, Terek RM, Chen Q. Matrilin-3 induction of IL-1 receptor antagonist is required for up-regulating collagen II and aggrecan as well as down-regulating ADAMTS-5 gene expression, Arthritis Research & Therapy, 2012, Sep 11;14(5):R197. PMID: 22967398