西安交通大學

 Dr. Bo LEI (雷波)

Professor, Group Leader (教授、研究小組主任）

Nanoscale Hybrid Biomaterials and Tissue Regeneration group(納米復合生物材料與組織再生研究小組）

Group website: http://gr.xjtu.edu.cn/web/rayboo

Contacts:  rayboo@xjtu.edu.cn, 029-83395361

個人簡介：主要研究方向為新型納米生物活性材料、可吸收高分子納米復合醫用材料合成（顆粒/薄膜/水凝膠/多孔支架）、功能化（熒光/電活性/磁性/抗菌/細胞介導）、生物醫學應用研究（組織修復再生、組織工程、基因細胞藥物載體、細胞影像、癌癥診斷治療），2010年于華南理工大學獲生物醫用材料方向工學博士學位，曾為國家人體組織功能重建工程技術研究中心助理研究員、韓國高麗大學研究教授 (Research Professor, Korea University, Korea)。與美國密西根大學（University of Michigan，USA)、首爾國立大學(SNU, Korea)、日本國立物質材料所（NIMS，Japan)、德國埃朗根-紐倫堡大學 (FAU, Germany) 有廣泛的科研協作聯系。主要主持和參與國家自然科學基金重點項目1項，國家自然科學基金面上項目1項，參與韓國國家衛生部、國家基金項目各1項。近五年發表各種SCI學術論文20篇，其中以第一作者/通訊作者身份在J. Mater. Chem, J. Biomed. Mater. Res Part A, J. Biomed. Mater. Res. Part B, J. Am. Ceram. Soc. 等國際一流生物材料期刊發表科研論文23篇，申請受理韓國發明專利3項。
歡迎具有材料、化學、生物、醫學等專業背景的同學報考CBERM中心碩士、博士研究生！！

Research Interests(研究方向)：

（1）Fabrication and properties of novel nanoscale bioactive biomaterials 新型納米生物活性醫用材料的合成與性能研究（納米晶/納米粒/納米多孔支架）。

（2）Synthesis and properties of Biodegradable polymer nanohybrids (nanocomposites)可吸收高分子納米復合醫用材料合成與性能研究（納米粒/薄膜/水凝膠/多孔支架）。

（3）Bio-functionalization of nano-biomaterials and polymer hybrids 納米生物材料與高分子復合材料生物功能化研究（熒光/電活性/磁性/抗菌/細胞介導）

（4）Biomedical applications of nanoscale biomaterials and polymer nanohybrids 納米生物材料與高分子復合材料生物醫學應用研究（組織再生與工程、基因細胞藥物載體、細胞影像、癌癥診斷治療）

Research ID: http://www.researcherid.com/rid/B-9463-2009

Research Interests (研究內容)： 

● Biomimetic, biodegradable and bioactive polymer-silicate based hybrid biomaterials for bone tissue

regeneration and tissue engineering applications

● Biomimetic and bioabsorbable polymer-based hybrid biomaterials for skin and vascular tissue

regeneration and tissue engineering applications

● Smart and biomimetic drug/protein delivery system design and biomedical applications

● Biocompatibility (blood, tissue, cells) studies and evaluation for biomimetic hybrid biomaterials.

Representative Publications (代表性論文)： 

1. Lei B, Chen X, Han X. Versatile fabrication of nanoscale sol-gel bioactive glass particles for highly efficient tissue regeneration. J. Mater. Chem, 2012, 22(33), 16906-16913 (IF=5.96). Link: http://pubs.rsc.org/en/content/articlepdf/2012/jm/c2jm31384g

2.Nanofibrous gelatin-silica hybrids scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation. J.Mater. Chem, 2012,  22(28), 14133-14140 (IF=5.96). Link: http://pubs.rsc.org/en/content/articlepdf/2012/jm/c2jm31290e

3. Lei B, Chen X, Han X, Li Z. Unique physical-chemical, apatite-forming properties and human marrow mesenchymal stem cells (HMSCs) response of sol-gel bioactive glass microspheres. J. Mater. Chem,  2011, 21 (34)12725-12734 (IF=5.96). Link: http://pubs.rsc.org/en/content/articlehtml/2011/jm/c1jm11547b

4. Lei B, Shin K H, Koh Y H, Kim H E. Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(ε-caprolactone) polymer for bone tissue

regeneration. J. Biomed. Mater. Res. Part B, 2012, 100(4):967-975 (IF=2.22).

Link: http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.32659/full

5. Lei B, Shin K H, Moon Y W, Noh D Y, Koh Y H, Jin Y H, Kim H E. Synthesis and bioactivity of sol-gel derived porous, bioactive glass microspheres using chitosan as novel biomolecular template. Journal of American Ceramic Society, 2012; 95(1):30-33 (IF=2.27). Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1551-2916.2011.04918.x/full

6. Lei B, Chen X, Wang Y, Zhao N, Du C, Fang L. Surface nanoscale patterning of bioactive glass to support cellular growth and differentiation. J. Biomed. Mater. Res. Part A, 2010, 9 (4),1091-1099 (IF=3.04).  Link: http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.32776/full

7. Lei B, Chen X, Wang Y, Zhao N. Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheres. Materials Letters, 2009, 63(20)1719 (IF=2.30). Link: http://dx.doi.org/10.1016/j.matlet.2009.04.041

8. Lei B, Chen X, Wang Y, Zhao N, Miao G. Fabrication of porous bioactive glass particles by one step sintering. Materials Letters, 2010, 64(21): 2293-2295 (IF=2.30)   Link: http://dx.doi.org/10.1016/j.matlet.2010.07.066

9. Lei B, Chen X, Wang Y, Zhao N, Du C, Fang L. Influence of sintering temperature on the pore structure and apatite formation of a sol-gel derived bioactive glass. Journal of the American Ceramic Society, 2010.93 (1) 32-35 (IF=2.27). Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1551-2916.2009.03358.x/full