空軍軍醫(yī)大學(xué)

姓名：王志鵬

性別：男　

職稱：副教授

學(xué)院：藥學(xué)系

研究方向：腫瘤藥理學(xué)研究

王志鵬，男，第四軍醫(yī)大學(xué)藥學(xué)院藥理學(xué)教研室副教授，碩士生導(dǎo)師。2000年畢業(yè)于第四軍醫(yī)大學(xué)臨床醫(yī)學(xué)專業(yè)，獲學(xué)士學(xué)位。2003、2006年畢業(yè)于第四軍醫(yī)大學(xué)藥理學(xué)專業(yè)，獲碩士、博士學(xué)位。2007年7月至2009年10月赴丹麥哥本哈根大學(xué)醫(yī)學(xué)院進(jìn)行博士后研究 。

負(fù)責(zé)國(guó)家自然科學(xué)基金課題2項(xiàng)，陜西省科技公關(guān)課題1項(xiàng)，2010年獲得第四軍醫(yī)大學(xué)優(yōu)秀留學(xué)回國(guó)人員啟動(dòng)基金（第2層次）資助。參與國(guó)家自然科學(xué)基金、973前期研究專項(xiàng)、陜西省13115科技創(chuàng)新項(xiàng)目等共6項(xiàng)。發(fā)表研究論文40余篇，其中SCI雜志發(fā)表論文13篇。申請(qǐng)發(fā)明專利2項(xiàng)。是中國(guó)藥理學(xué)會(huì)會(huì)員和歐洲癌癥研究學(xué)會(huì)會(huì)員。陜西省藥品不良反應(yīng)監(jiān)測(cè)委員會(huì)專家。主要從事腫瘤藥理學(xué)研究工作。

近年發(fā)表論文：

1.Wang Z, Liu L, Wang M, Shen M, Li J, Liu J, Li C, Xin C, Zhu S, Mei Q, Wang Y. NOTCH1 regulates migration and invasion of skin cancer cells by E-cadherin repression. Mol Cell Biochem. 2011 Oct 29. [Epub ahead of print]

2. Wang Z, Pedersen E, Basse A, Lefever T, Karine P, Kapoor S, Mei Q, Karlsson R, Brakebusch C.Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene, 2010, 29:3362-73

3. Wang Z, Liang B, Mei Q. Routine early angioplasty after fibrinolysis. N Engl J Med. 2009, 361:1509

4. Wang Z, Jin H, Xu R, Mei Q, Fan D. Triptolide inhibits proliferation and migration, enhance apoptosis in inflammatory bowel diseases induced colorectal cancer via Rac1/JAK/STAT3 pathway. Exp mol med 2009 31;41:717-27.

5. Wang Z, Jin H, Li C, Hou Y, Mei Q, Fan D. Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway. Int J toxicol 2009, 28:177-89

6. Wang Z, Mingkai L, Shuyu C, Min J, Jingru M, Xue M, Yuemei W, Xiaoxing L. Toxicity of Coenzyme Q10: A report of 90-day repeated dose toxicity study in rats. J Toxicol Sci. 2007;32(5):505-14.

7. Wang Z, Li L, Qibing M, Linna L, Yuhua R, Rong Z . Increased expression of heat shock protein (HSP)72 in a human proximal tubular cell line (HK-2) with gentamicin-induced injury. J Toxicol Sci. 2006; 31: 61-70

8. Wang Z, Liu L, Mei Q, Liu L, Ran Y, Zhang R . Increased expression of heat shock protein 72 protects renal proximal tubular cells from gentamicin-induced injury. J Korean Med Sci. 2006; 21:904-10

9. Jin H, Wang Z*, Fan D.R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75NTR induction. Mol Pharm. 2010 ;7:156-68..(co-first author)

10. Wen A, Wang Z, Hang T, Jia Y, Zhang T, Wu Y, Gao X, Yang Z (2007). Analysis of sofalcone in human plasma by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;856:348-52.

11. Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, Brakebusch C. Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1. Exp Cell Res, 2009, 815: 1480-1489

12. Richard K, Esben P, Wang Z, Cord B. RhoGTPases function in tumor. BBA Cancer 2009, 1796: 91-8

13.Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C. RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell. 2011; 22: 593-605.