空軍軍醫大學

姓名：王志鵬

性別：男　

職稱：副教授

學院：藥學系

研究方向：腫瘤藥理學研究

王志鵬，男，第四軍醫大學藥學院藥理學教研室副教授，碩士生導師。2000年畢業于第四軍醫大學臨床醫學專業，獲學士學位。2003、2006年畢業于第四軍醫大學藥理學專業，獲碩士、博士學位。2007年7月至2009年10月赴丹麥哥本哈根大學醫學院進行博士后研究 。

負責國家自然科學基金課題2項，陜西省科技公關課題1項，2010年獲得第四軍醫大學優秀留學回國人員啟動基金（第2層次）資助。參與國家自然科學基金、973前期研究專項、陜西省13115科技創新項目等共6項。發表研究論文40余篇，其中SCI雜志發表論文13篇。申請發明專利2項。是中國藥理學會會員和歐洲癌癥研究學會會員。陜西省藥品不良反應監測委員會專家。主要從事腫瘤藥理學研究工作。

近年發表論文：

1.Wang Z, Liu L, Wang M, Shen M, Li J, Liu J, Li C, Xin C, Zhu S, Mei Q, Wang Y. NOTCH1 regulates migration and invasion of skin cancer cells by E-cadherin repression. Mol Cell Biochem. 2011 Oct 29. [Epub ahead of print]

2. Wang Z, Pedersen E, Basse A, Lefever T, Karine P, Kapoor S, Mei Q, Karlsson R, Brakebusch C.Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene, 2010, 29:3362-73

3. Wang Z, Liang B, Mei Q. Routine early angioplasty after fibrinolysis. N Engl J Med. 2009, 361:1509

4. Wang Z, Jin H, Xu R, Mei Q, Fan D. Triptolide inhibits proliferation and migration, enhance apoptosis in inflammatory bowel diseases induced colorectal cancer via Rac1/JAK/STAT3 pathway. Exp mol med 2009 31;41:717-27.

5. Wang Z, Jin H, Li C, Hou Y, Mei Q, Fan D. Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway. Int J toxicol 2009, 28:177-89

6. Wang Z, Mingkai L, Shuyu C, Min J, Jingru M, Xue M, Yuemei W, Xiaoxing L. Toxicity of Coenzyme Q10: A report of 90-day repeated dose toxicity study in rats. J Toxicol Sci. 2007;32(5):505-14.

7. Wang Z, Li L, Qibing M, Linna L, Yuhua R, Rong Z . Increased expression of heat shock protein (HSP)72 in a human proximal tubular cell line (HK-2) with gentamicin-induced injury. J Toxicol Sci. 2006; 31: 61-70

8. Wang Z, Liu L, Mei Q, Liu L, Ran Y, Zhang R . Increased expression of heat shock protein 72 protects renal proximal tubular cells from gentamicin-induced injury. J Korean Med Sci. 2006; 21:904-10

9. Jin H, Wang Z*, Fan D.R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75NTR induction. Mol Pharm. 2010 ;7:156-68..(co-first author)

10. Wen A, Wang Z, Hang T, Jia Y, Zhang T, Wu Y, Gao X, Yang Z (2007). Analysis of sofalcone in human plasma by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;856:348-52.

11. Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, Brakebusch C. Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1. Exp Cell Res, 2009, 815: 1480-1489

12. Richard K, Esben P, Wang Z, Cord B. RhoGTPases function in tumor. BBA Cancer 2009, 1796: 91-8

13.Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C. RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell. 2011; 22: 593-605.