蘭州大學

學習經歷

■ 1993.9-1998.7，清華大學材料科學與工程系，獲工學學士學位；

■ 1998.9-2003.7，清華大學生物科學與技術系，獲理學博士學位。

工作經歷

■ 2003.9至今，蘭州大學生命科學學院，教學科研；

教學及指導研究生情況

研究團隊：教授2人、副教授1人、講師1人、實驗師1人，研究生19人。

發表論文及專著

已發表SCI論文24篇，共獲SCI引用600余次；代表性論文（*通訊作者）：

[1] Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, in press. (5-Year IF 5.57)

[2] Su H.-X., Zhou H.-H., Wang M.-Y., Cheng J., Zhang S.-C., Hui F., Chen X-Z, Liu S.-H., Liu Q.-J., Zhu Z.-J., Hu Q.-R., Wu Y.*, Ji S.-R.* (2014) Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. Plos One, 9 (7): e102418. (5-Year IF 4.015)

[3] Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289 (20): 14283-14290. (5-Year IF 4.863)

[4] Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508. (5-Year IF 11.078)

[5] Ma X, Ji S.-R., Wu Y.* (2013) Regulated conformation changes in C-reactive protein orchestrate its role in atherogenesis. Chinese Science Bulletin, 58(14): 1642-1649. (5-Year IF 1.421)

[6] Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756. (5-Year IF 4.863)

[7] El Kebir D., Zhang Y., Potempa L.A., Wu Y., Fournier A., Filep J.G.* (2011) C-reactive protein-derived peptide 201–206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32. Journal of Leukocyte Biology, 90(6): 1167-1175. (5-Year IF 4.663)

[8] Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196. (5-Year IF 6.045)

[9] Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*, Wu Y.* (2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure, 19(4): 515-522. (5-Year IF 6.337)

[10] Wang B.-B., Yu C.-H., Xi Y.-B., Cai H.-C., Wang J., Zhou S.-R., Zhou S.-Y., Wu Y., Yan Y.-B.*, Ma X.*, Xie L.-X.* (2011) A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family. Human Mutation, 32(1): E1939-E1947. (5-Year IF 5.416)

[11] Liu R.-Q., Zhou Q.-H., Ji S.-R., Zhou Q., Feng D., Wu Y., Sui S.-F.* (2010) Membrane localization of β-Amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. Journal of Biological Chemistry, 285(26): 19986-19996. (5-Year IF 4.863)

[12] Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816. (5-Year IF 6.045)

[13] Shen Q.T., Bai X.C., Chang L.F., Wu Y., Wang H.W., Sui S.-F.* (2009) Bowl-shaped oligomeric structures on membranes as DegP’s new functional forms in protein quality control. Proceedings of the National Academy of Sciences of the United States of America, 106(12): 4858-4863. (5-Year IF 10.727)

[14] Jiang J., Zhang X., Chen Y., Wu Y., Zhou Z.H., Chang Z., Sui S.-F.* (2008) Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proceedings of the National Academy of Sciences of the United States of America, 105(33): 11939-11944. (5-Year IF 10.727)

[15] Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294. (5-Year IF 6.045)

[16] Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (5-Year IF 6.430)

[17] Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (5-Year IF 4.595)

[18] Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (5-Year IF 10.727)

[19] Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279. (5-Year IF 4.863)

[20] Wu Y., Wang H.-W., Ji S.-R., Sui S.-F.* (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits. Acta Crystallographica Section D-Biological Crystallography, 59(5): 922-926. (5-Year IF 9.416)

研究方向

■ 重要蛋白質參與慢性炎癥疾病調控的分子機制；
■ 電鏡結構生物學解析蛋白質復合體的構象變化；
■ 微小RNA（microRNA）與植物逆境適應。

項目成果

■ 國家自然科學基金重點項目1項，面上項目9項（已結題5項）；
■ 國家自然科學基金優秀青年科學基金1項；
■ 國家自然科學基金國際合作項目2項（已結題2項）；
■ 霍英東青年教師基金1項；
■ 教育部新世紀優秀人才支持計劃2項（已結題2項）；
■ 教育部博士點基金3項（已結題2項）；
■ 教育部科技研究重點項目1項（已結題1項）；
■ FEI合作研究基金1項；
■ 中央高校基本科研業務費重點項目1項；
■ 蘭州大學人才引進專項2項（已結題2項）。

榮譽、獲獎

■ 清華大學優秀博士學位論文一等獎，2003；
■ 教育部新世紀優秀人才支持計劃，2005；
■ 國家自然科學二等獎（3/5），2005；
■ 第四屆亞太血栓與止血大會青年研究獎，2006；
■ 第六屆甘肅青年科技獎，2007；
■ 第十三屆甘肅五四青年獎章標兵，2009；
■ 第一屆貝時璋青年生物物理學家獎，2009；
■ 第十二屆霍英東青年教師基金，2010；
■ 國家自然科學基金優秀青年基金，2012。

社會工作

■ 中國生物物理學會理事，2006-；
■ 中國電子顯微鏡學會理事，2008-；
■ 生物物理學報副主編，2010-。