蘭州大學

學習經(jīng)歷

1996.9－2000.6，蘭州大學生物化學專業(yè)，學士
2001.9－2006.6，蘭州大學生物化學專業(yè)，碩博連讀，導師：王銳
工作經(jīng)歷 2000.8-2001.7，甘肅榆中恩玲中學，教師，研究生支教工作
2006.7-2011.4，蘭州大學生命科學學院，講師
2011.5-至今，蘭州大學生命科學學院，副教授

教學及指導研究生情況

承擔本科生《分子生物學》、《生物技術(shù)制藥》課程。

碩士生導師。

發(fā)表論文及專著

Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Han RW, Chang M*, Wang R*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 doi:10.1016/j.nlm.2015.05.010 (SCI)
Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M*, Wang R*. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48. (SCI)
Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem. 2014 ;107:32-6. (SCI)
Han, RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Abeta42 in mice novel object and object location recognition tasks, Neuropharmacology, 2013;70:261-7.(SCI)
Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R*, Han YF. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res. 2012;1470:59-68. (SCI)
Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang R*. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-83. (SCI)
Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang R*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-63. (SCI)
Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009;1271:36-48. (SCI)
Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R*. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul. Pept. 2009;156:90-5. (SCI)
Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;30(7): 1313-17. (SCI)
 Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro. Lett. 2009;455:74-7. (SCI)
Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40. (SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept. Lett. 2009;16:1074-80. (SCI)
常民, 彭雅麗, 李威, 王銳. 神經(jīng)肽S的功能與構(gòu)效關(guān)系研究進展. 生物物理學報. 2009;03:175-82.
Li Z, Zhou LX, Zhang BH, Yan X, Li J, Peng YL, Chang M, Dong SL, Wang R*. Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell.Pharmazie. 2008;63(9):676-85.(SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23. (SCI)
Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4, Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul. Pept. 2006;134:75-81. (SCI)
Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R*. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides. 2006;27:1297-304. (SCI)
Yang Q, Chen Y, Fu C, Chang M, Peng YL, Wang R*. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett. 2006;13(2):185-8.(SCI)

專利：

一種固液相縮合制備胸腺肽α1的方法，申請?zhí)枺篊N201310523706.1；
液相片段縮合制備胸腺肽α1的方法，申請?zhí)枺篊N201310523577.6；
片段縮合制備醋酸鮭魚降鈣素的方法，申請?zhí)? CN201410420967.5;
片段縮合制備特利加壓素的方法，申請?zhí)? CN201410554759.4
一種片段縮合制備曲普瑞林的方法，申請?zhí)? CN201410743707.1
一種片段縮合制備醋酸去氨加壓素的方法，申請?zhí)? CN201410748612.9
一種片段縮合制備醋酸阿托西班的方法，申請?zhí)? CN201410802681.3
片段縮合制備利拉魯肽的方法，申請?zhí)枺篊N201510079168.0

研究方向

1、神經(jīng)肽

2、多肽合成

3、多肽藥理學

項目成果

主持項目：

1、神經(jīng)肽S與疼痛下行抑制通路關(guān)系的研究（30900445）。國家自然科學基金委。

2、一種治療阿爾茨海默病的新多肽藥物的設(shè)計和活性研究（0708NKCA111）。甘肅省科技廳。

3、新的胸腺肽α1生產(chǎn)工藝的研究（07-3-08）。蘭州市科技局。

參與項目：

1、若干多肽合成和化學修飾的新方法研究及其在多肽藥物產(chǎn)業(yè)開發(fā)中的應(yīng)用（2009ZX09503）。科技部“重大新藥創(chuàng)制”科技重大專項。