蘭州大學

學習經歷

2010年3月—2011年3月，美國賓夕法尼亞大學化學系, 訪問學者，合作者Patrick J. Walsh教授。
2000年9月—2003年6月，蘭州大學生命科學學院生物化學與分子生物學研究所，從事博士學位的學習和研究工作，獲得理學博士學位，導師王銳教授。
1998年9月—2000年6月，蘭州大學生命科學學院生物化學與分子生物學研究所，從事碩士學位的學習和研究工作，獲得理學碩士學位，導師王銳教授。
1986年9月—1990年6月，蘭州大學原生物系植物生理專業學習，獲得理學學士學位。

工作經歷

2012-, 蘭州大學，生命科學學院生物化學與分子生物學研究所，教授，博士生導師。
2010-2012，蘭州大學，生命科學學院生物化學與分子生物學研究所，副教授，博士生導師。
2007-2010，蘭州大學，生命科學學院生物化學與分子生物學研究所，副教授，碩士生導師。
2005-2007，蘭州大學，生命科學學院生物化學與分子生物學研究所，講師，碩士生導師。
2003-2005，蘭州大學，生命科學學院生物化學與分子生物學研究所，講師。
1990-1997，甘肅省科學院，生物研究所，研究實習員。

教學及指導研究生情況

1. 本科生教學，主講《生物化學》

2. 指導研究生情況

發表論文及專著

一、發表SCI論文情況

Yong-Xin Yang, Yue Liu, Lei Zhang, Yan-E Jia, Pei Wang, Fang-Fang Zhuo, Xian-Tao An, and Chao-Shan Da, Aryl Bromides as Inexpensive Starting Materials in the Catalytic Enantioselective Arylation of Aryl Aldehydes: the Additive TMEDA Enhances the Enantioselectivity,J. Org. Chem. 2014, accepted article, DOI: 10.1021/jo502070r, published on line on Oct. 3, 2014.(pdf)
Lin Sun, Qi-Peng Guo, Xiao Li, Lei Zhang, Yu-Yan Li and Chao-Shan Da, C2-Symmetric Homobimetallic Zinc Complexes as Chiral Catalysts for the Highly Enantioselective Hydrophosphonylation of Aldehydes, Asian J. Org. Chem. 2013, 2, 1031-1035. (pdf) (html)
Lei Zhang, Lin Sun, Yu-Yan Li, Yue Liu, Yong-Xin Yang, Rui Yuan, Pei Wang, Chao-Shan Da, Catalytic Asymmetric Arylation of Enals to Enantioenriched Linear Trisubstituted Allylic Secondary Alcohols by using Aryl Lithiums Generated In Situ from Aryl Bromides， ChemCatChem 2013, 5, 3516-3519. (pdf) (html)
Zhi-Xue Du, Li-Yuan Zhang, Xin-Yuan Fan, Feng-Chun Wu, Chao-Shan Da, Highly Enantioselective Biomimetic Intramolecular Dehydration: Kinetic Resolution of β-Hydroxy Ketones Catalyzed by β-Turn Tetrapeptides, Tetrahedron Lett. 2013,54, 2828-2832. (pdf) (html)
Fang-Fang Zhuo, Wen-Wen Xie, Yong-Xin Yang, Lei Zhang, Pei Wang, Rui Yuan, Chao-Shan Da, TMEDA-Assisted Effective Direct ortho-Arylation of Electron-Deficient N-heteroarenes with Aromatic Grignard Reagents, J. Org. Chem. 2013, 78, 3243-3249. (pdf) (html)
Zhang, J.; Stanciu, C.; Wang, B.; Hussain, M. M.; Da, C. S.; Carroll, P. J.; Dreher, S. D.; Walsh, P. J. Palladium-Catalyzed Allylic Substitution with (η6-Arene-CH2Z)Cr(CO)3- Based Nucleophiles. J. Am. Chem. Soc. 2011, 133, 20552-20560.(pdf)(html)
Qin, L.; Li, L.; Yi, L.; Da, C. S.; Zhou, Y. F.Direct Asymmetric N-Specific Reaction of Nitrosobenzene with Aldehydes Catalyzed by a Chiral Primary Amine-Based Organocatalyst, Chirality 2011, 23, 527-533.(pdf)(html)
Fan, X. Y.; Yang, Y. X.; Zhuo, F. F.; Yu, S. L.; Li, X.; Guo, Q. P.; Du, Z. X.; Da, C. S. AlCl3 and BDMAEE: A Pair of Potent Reactive Regulators of Aryl Grignard Reagents and Highly Catalytic Asymmetric Arylation of Aldehydes Chem. Eur. J. 2010, 16, 7988-7991. (pdf)(html) This work was highlighted by Synfacts (Yamamoto, H.; Brady, P. Synfacts 2010, 10, 1164).
Liu, Y.; Da, C. S.; Yu, S. L.; Yin, X. G.; Wang, J. R.; Fan, X. Y.; Li, W. P.; Wang, R. Catalytic Highly Enantioselective Alkylation of Aldehydes with Deactivated Grignard Reagents and Synthesis of Bioactive Intermediate Secondary Arylpropanols J. Org. Chem. 2010, 75, 6869 -6878.(pdf)(html)
Zhu, G. J.; Da, C. S.; Jia, Y. N.; Ma, X.; Yi, L. Direct Asymmetric Aldol Reaction Catalyzed by C2-symmetrical Chiral Primary Amine Organocatalysts,Lett. Org. Chem. 2010, 7, 15-20.
Da, C. S.; Wang, J. R.; Yin, X. G.; Fan, X. Y.; Liu, Y.; Yu, S. L., Highly Catalytic Asymmetric Addition of Deactivated Alkyl Grignard Reagents to Aldehydes, Org. Lett. 2009, 11, 5578-5581. (pdf) (html). This work was highlighted by Synfacts (Lautens, M.; Candito, D. A. Synfacts 2010, 3, 323.) and Organic Chemistry: Highlights (Taber, D. F. Org. Chem. Highlights 2010, July 12.)
Wu, F. C.; Da, C. S.; Du, Z. X.; Guo, Q. P.; Li, W. P.; Yi, L.; Jia, Y. N.; Ma, X. N-Primary-Amine-Terminal β-Turn Tetrapeptides as Organocatalysts for Highly Enantioselective Aldol Reaction, J. Org. Chem. 2009, 74, 4812-4818.(pdf) (html).
Da, C. S.; Che, L. P.; Guo, Q. P.; Wu, F. C.; Ma, X.; Jia, Y. N.2,4-Dinitrophenol as An Effective Cocatalyst: Greatly Improving the Activities and Enantioselectivities of Primary Amine Organocatalysts for Asymmetric Aldol Reactions, J. Org. Chem. 2009, 74, 2541-2546. (pdf) (html).
Ma, X.; Da, C. S.; Yi, L.; Jia, Y. N.; Guo, Q. P.; Che, L. P.; Wu, F. C.; Wang, J. R.; Li, W. P. Highly efficient primary amine organocatalysts for the direct asymmetric aldol reaction in brine, Tetrahedron: Asymmetry 2009, 20, 1419-1424.(pdf) (html)
Jia, Y. N.; Wu, F. C.; Ma, X.; Zhu, G. J.; Da, C. S. Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine, Tetrahedron Lett. 2009, 50, 3059-3062.(pdf) (html)
Yang, R. Y.; Da, C. S.; Yi, L.; Wu, F. C.; Li, H. Asymmetric conjugate addition of unmodified propionaldehyde to β-nitrostyrenes catalyzed by readily available proline-based dipeptidols, Lett. Org. Chem. 2009, 6, 44-49.
Li, H.; Da, C.-S.; Xiao, Y. H.; Li, X.; Su, Y. N. Direct Asymmetric Aldol Reaction of Aryl Ketones with Aryl Aldehydes Catalyzed by Chiral BINOL-Derived Zincate Catalyst, J. Org. Chem. 2008, 73, 7398-7401.(pdf) (html)
Da, C. S.; Ni, M.; Han, Z. J.; Yang, F.; Wang, R. Novel non-azacyclo 1,2-amino alcohols derived from phenylalanine and highly enantioselective addition of diethylzinc to aryl aldehydes, J. Mol. Catal. A: Chem. 2006, 245, 1-7.(pdf) (html)
Han, Z. J.; Da, C. S.; Qiu, L.; Ni, M.; Zhou, Y. F.; Wang, R. The natural amino acid derived chiral sulfonamide ligands in the catalytic asymmetric addition of phenylacetylene to aldehydes, Lett. Org. Chem. 2006, 3, 143-148.
Ni, M.; Wang, R.; Han, Z. J.; Mao, B.; Da, C. S.; Liu, L.; Chen, C. Synthesis of new C2-symmetrical bissulfonamide ligands and application in the enantioselective addition of alkynylzinc to aldehydes and ketones, Adv. Synth. Catal. 2005, 347, 1659-1665.(pdf)
Kang, Y. F.; Wang, R.; Liu, L.; Da, C. S.; Yan, W. J.; Xu, Z. Q. Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral oxazolidine ligands, Tetrahedron Lett. 2005, 46, 863-865.(pdf) (html)
Han, Z. J.; Da, C. S.; Xu, Z. Q.; Ni, M.; Wang, R. The asymmetric addition of phenylacetylene to aldehydes catalyzed by L-leucine derived chiral sulfonamide alcohol ligands, J. Mol. Catal. A.: Chem. 2005, 236, 32-38. (pdf) (html)
Da, C. S.; Xin, Z. Q.; Xiao, Y. N.; Wang, H. S.; Su, W.; Yang, F.; Wang, R. Novel β-Aminoalcohols with Bulky Substituents and the Application in Enantioselective Addition of Diethyl Zinc to Arylaldehydes(in Chinese), Chin. J. Org. Chem. 2004, 24, 943-945.(pdf)
Zhou, Y. F.; Wang, R.; Xu, Z. Q.; Yan, W. J.; Liu, L.; Gao, Y. F.; Da, C. S. Boc-L-proline as a new chiral ligand for enant ioselective phenylacetylene addition to aromatic aldehydes, Tetrahedron: Asymmetry 2004, 15, 589-591.(pdf) (html)
Xu, Z. Q.; Wang, R.; Xu, J. K.; Da, C. S.; Yan, W. J.; Chen, C. Highly enantioselective addition of phenylacetylene to aldehydes catalyzed by a β-sulfonamide alcohol-titanium complex, Angew. Chem., Int. Ed. 2003, 42, 5747-5749.(pdf) (html)
Wang, H. S.; Da, C. S.; Xin, Z. Q.; Su, W.; Xiao, Y. N.; Liu, D. X.; Wang, R. Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Ni(acac)2 and chiral β-amino alcohols, Chin. J. Chem. 2003, 21, 1105-1107.(pdf)
Da, C. S.; Han, Z. J.; Ni, M.; Yang, F.; Liu, D. X.; Zhou, Y. F.; Wang, R. A convenient synthesis of piperidine-based β-amino alcohols from L-Phe and highly enantioselective addition of diethyl zinc to aldehydes, Tetrahedron: Asymmetry 2003, 14, 659-665. (pdf) (html)
Da, C. S.; Wei, J.; Dong, S. L.; Xin, Z. Q.; Liu, D. X.; Xu, Z. Q.; Wang, R. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide, Synth.Commun. 2003, 33, 2787-2792.(pdf) (html)
Xin, Z. Q.; Da, C. S.; Dong, S. L.; Liu, D. X.; Wei, J.; Wang, R. A novel method for the synthesis of (R)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid by asymmetric oxidative coupling of a chiral β-naphthol derivative catalyzed by CuCl, Tetrahedron: Asymmetry 2002, 13, 1937-1940.(pdf) (html)
Liu, D. X.; Zhang, L. C.; Wang, Q.; Da, C.-S.; Xin, Z. Q.; Wang, R.; Choi, M. C. K.; Chan, A. S. C. The application of chiral aminonaphthols in the enantioselective addition of diethylzinc to aryl aldehydes, Org. Lett. 2001, 3, 2733-2735.(pdf) (html)
Yang, X. W.; Shen, J. H.; Da, C. S.; Wang, H. S.; Su, W.; Liu, D. X.; Wang, R.; Choi, M. C. K.; Chan, A. S. C. Highly enantioselective addition of diethylzinc to aldehydes catalyzed by a new chiral C2-symmetric Ti-diol complex, Tetrahedron Lett. 2001, 42, 6573-6575.(pdf) (html)
Liu, D. X.; Wang, Q.; Zhang, L. C.; Da, C. S.; Wang, R. Trimethylsilylcyanation of Aromatic Aldehydes Catalyzed by BINOL-Li Salt (in Chinese), Chem. J. Chin. Univ. 2001, 22, 601-602.(pdf) (html)
Yang, X. W.; Su, W.; Liu, D. X.; Wang, H. S.; Shen, J. H.; Da, C. S.; Wang, R.; Chan, A. S. C. Preparation and application of polymer-grafted Ti-BINOL complexes as chiral catalysts in the enantioselective addition of diethylzinc to aldehydes, Tetrahedron 2001, 56, 3511-3516.(pdf) (html)
Yang, X. W.; Sheng, J. H.; Da, C. S.; Wang, H. S.; Su, W.; Wang, R.; Chan, A. S. C. Polymer-Supported BINOL Ligand for the Titanium-Catalyzed Diethylzinc Addition to Aldehydes: A Remarkable Positive Influence of the Support on the Enantioselectivity of the Catalyst, J. Org. Chem. 2000, 65, 295-266.(pdf) (html).
Su, W.; Wang, H. S.; Da, C. S.; Wang, R. Asymmetric Synthesis of Optically Active 1,1'-Bi-2-Naphthol (in Chinese), Chem. J. Chin. Univ. 2000, 21, 1408-1409.(pdf)(html)
Wang, H. S.; Yang, X. W.; Su, W.; Liu, D. X.; Da, C. S.; Wang, R. Preparation of a Polymer Supported BINOL-Ti Catalyst and Its Application in Asymmetric Addition of Diethylzinc to Aldehydes (in Chinese), Chem. J. Chin. Univ. 2000, 21, 1524-1525. (pdf) (html)
Yang, X. W.; Shen, J. H.; Da, C. S.; Wang, R.; Choi, M. C. K.; Yang, L.; Wong, K. Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes, Tetrahedron: Asymmetry 1999, 10, 133-138.(pdf) (html)
 
二、專利申請
達朝山，樊新元，卓芳芳，楊永新，不對稱催化法合成光學活性二級芳基醇，申請號：CN 201010188258，公開號： CN101844958， 2010年5月27日。
達朝山，蘇亞寧，洪滿貴，保英明，曹福軍，一種生長抑素的合成方法，申請號：CN200910142420.2，公開號：CN101570570，2009年6月3日,專利號：ZL 2009 1 0142420.2，授權公告日：2013年07月10日。

三、參編書籍
達朝山，王 銳：高效手性配體的設計合成及其在二乙基鋅對醛的不對稱加成反應中的應用，《不對稱有機反應》（第一版），李月明、范青華、陳新滋主編，化學工業出版社，北京，中國，2005年，第6章：pp275-291。

研究方向

1. 合成多肽作為人工酶仿生催化的化學生物學

2. 手性藥物的高效和綠色不對稱合成

3. 生物活性肽的高效合成與工藝開發

項目成果

國家自然科學基金項目：

格氏試劑的鈍化及其在手性配體作用下對醛的不對稱加成反應研究，國家自然科學基金，No. 20672051，28萬元，2007年至2009年。
脫水酶的高級結構肽模擬物的設計、合成及其催化β-羰基醇脫水反應過程中的手性識別作用研究，國家自然科學基金，No. 21072087, 36萬元，2011年至2013年。

榮譽、獲獎

2008年甘肅省自然科學獎一等獎。完成人：王銳，許兆青，達朝山，楊曉武，張邦志。項目名稱：具有重要醫藥用途的若干不對稱催化合成方法學研究 。（2008-Z1-002-R3）。
2009第十六屆“甘肅省普通高等學校青年教師成才獎”。

社會工作

甘肅省化學會第十六屆理事，現任甘肅省化學會第十七屆理事會理事。