蘭州大學(xué)

姓 名: 張小郁
Name: Zhang Xiaoyu
職 稱：教授，碩士生導(dǎo)師
Duty: Professor
E-mail：zhangxyu@lzu.edu.cn

科研方向

1、采用規(guī)范的細(xì)胞和分子生物學(xué)/生理學(xué)技術(shù)進(jìn)行有關(guān)生理、藥理學(xué)方面的研究。
2、采用細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)、氧化脅迫以及細(xì)胞凋亡技術(shù)對(duì)心血管疾病、糖尿病以及肥胖等進(jìn)行研究。
Research Interests：
1. Work with a major responsibility of physiology and pharmacology using standard cellular and molecular biology/physiology techniques.
2. Focus on cell signaling, oxidative stress, and apoptosis in a number of cardiovascular diseases, diabetes, and obesity.

榮譽(yù)稱號(hào)及獎(jiǎng)勵(lì)：

1. 2004年甘肅省醫(yī)療衛(wèi)生中青年學(xué)術(shù)技術(shù)帶頭人。
2. 《葡萄籽中原花青素對(duì)阿霉素增效減毒作用及機(jī)理研究》榮獲2006年甘肅省自然科學(xué)二等獎(jiǎng)（1/5），甘肅省高校科技進(jìn)步一等獎(jiǎng)（1/8），蘭州大學(xué)優(yōu)秀博士論文。
3. 2007年榮獲蘭州大學(xué)度首屆“隆基中青年教師教學(xué)骨干獎(jiǎng)”，獲得國家留學(xué)基金委資助作為訪問學(xué)者去美國進(jìn)行科學(xué)研究一年，提高科研水平。
4. 2011年，第十一屆全國多媒體課件大賽決賽三等獎(jiǎng)（第三完成人）
5. 2007年， 《生理學(xué)立體教學(xué)模式的探索——依托精品課程推動(dòng)教學(xué)創(chuàng)新》 蘭州大學(xué)教學(xué)成果二等獎(jiǎng)（第四完成人）
Honors and awards：
1. In 2004, I won the Discipline Leader on Young and Middle-aged Science and Technology of Public Health Department of Gansu.
2. In 2006, Mechanisms of Proanthocyanidin from Grape Seeds in both Potentiating Anti-tumor Activity and Reducing Toxicity of Doxorubicin obtained the second prize of Gansu Provincial Natural Science, the first prize of scientific and techonology progress in Gansu Provincial advanced colleges and was entitled as the Excellence Doctor Paper in Lanzhou University. (first author). 
3. In 2007, I won the prize of the Longji Excellence Teacher in Lanzhou University. At the same time, I got through the academic selection process organized by China Scholarship Council (CSC) and was granted the funds to study abroad for a year.

個(gè)人簡歷

張小郁，女，博士，碩士生導(dǎo)師，蘭州大學(xué)基礎(chǔ)醫(yī)學(xué)院醫(yī)學(xué)生理學(xué)研究所教授，學(xué)科帶頭人，甘肅省醫(yī)療衛(wèi)生中青年學(xué)術(shù)技術(shù)帶頭人，留美訪問學(xué)者。中國生理學(xué)會(huì)消化內(nèi)分泌生殖代謝生理專業(yè)委員會(huì)委員，甘肅省生理學(xué)會(huì)理事。
2008年12月至2009年11月在美國University of Wyoming和The State University of Newyork at Buffalo做訪問學(xué)者期間，利用分子生物學(xué)等先進(jìn)技術(shù)熟練掌握了心肌缺血再灌注損傷保護(hù)作用的世界前沿研究技術(shù)，發(fā)表相關(guān)SCI論文3篇；并對(duì)ISL抗腫瘤作用的分子機(jī)制進(jìn)行了系統(tǒng)研究，論文<Natural antioxidant-Isoliquiritigenin selectively inhibits growth of prostate cancer cells>已于2010年發(fā)表在SCI刊物Clin Exp Physiol Pharm上。2006年獲甘肅省自然科學(xué)進(jìn)步二等獎(jiǎng)1項(xiàng)，發(fā)表科研論文30余篇，其中SCI收錄10余篇。完成甘肅省自然科學(xué)和蘭州市科技項(xiàng)目基金項(xiàng)目各一項(xiàng)。目前主持一項(xiàng)甘肅省自然科學(xué)基金項(xiàng)目。本項(xiàng)目作為負(fù)責(zé)人，全面負(fù)責(zé)課題的組織、管理和實(shí)施，負(fù)責(zé)實(shí)驗(yàn)設(shè)計(jì)、數(shù)據(jù)整理和分析、論文撰寫，指導(dǎo)模型制作和分子生物學(xué)檢測。
1. 1983年9月至1998年7月  在原蘭州醫(yī)學(xué)院臨床醫(yī)學(xué)系攻讀本科。
2. 1996年9月至1999年7月  在原蘭州醫(yī)學(xué)院藥理學(xué)攻讀碩士。
3. 2002年9月至2005年6月  在蘭大生命科學(xué)學(xué)院動(dòng)物生理學(xué)攻讀博士。

工作經(jīng)歷

1. 1998年9月至1996年7月  在蘭拖廠醫(yī)院任主治醫(yī)師。
2. 1999年7月至2000年6月  在原蘭州醫(yī)學(xué)院生理學(xué)教研室任助教。
3. 2000年7月至2002年6月  在原蘭州醫(yī)學(xué)院生理學(xué)教研室任講師。
4. 2002年7月至2004年11月  在原蘭州醫(yī)學(xué)院生理學(xué)教研室任副教授。
5. 2004年11月至2008年5月  在蘭州大學(xué)基礎(chǔ)醫(yī)學(xué)院生理學(xué)研究所任副教授。
6. 2008年5月---至今在蘭州大學(xué)基礎(chǔ)醫(yī)學(xué)院生理學(xué)研究所任教授。
7. 2008年12月至2009年12月  在美國懷俄明大學(xué)做訪問學(xué)者。

Resume
1. Sept. 2002--- June 2005Ph.D. in Physiology, the Life Science School of Lanzhou University, Lanzhou 730000, Gansu, P.R.China.
2. Sept. 1996--- June 1999M.S. in Pharmacology, the Department of Pharmacology of Lanzhou Medical College, Lanzhou 730000, Gansu,  P.R.China.
3. Sept. 1983---July 1988   B.S. in Clinical Medicine, the Department of Clinical Medicine of Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China.
Working Experiences
1. Dec. 2008--- Dec. 2008   visiting scholar in University of Wyoming, USA
2. May 2008---NowProfessor, Institute of Physiology，School of Basic Medicine Science, Lanzhou University, Lanzhou 730000, Gansu, P.R.China
3. Nov. 2004--- May 2008Associate Professor, Institute of Physiology，School of Basic Medicine Science, Lanzhou University, Lanzhou 730000, Gansu, P.R.China
4. July 2002--- Nov. 2004Associate Professor, Department of Physiology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
5、Oct. 2000---July 2002Lecturer, Department of Physiology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
6. July 1999---Oct. 2000   Assistant，Department of Physiology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
7. Sept. 1988--- July 1996   Attending physician, Hospital of Lanzhou Tractor Factory, Lanzhou 730050, Gansu, P.R.China
 
主持的科研項(xiàng)目：

1. 主持甘肅省省自然科學(xué)研究基金計(jì)劃項(xiàng)目一項(xiàng)（1208RJZA231），異甘草素抗腫瘤血管生成的機(jī)制研究，2012.1-2014.12
2. 主持甘肅省省自然科學(xué)研究基金計(jì)劃項(xiàng)目一項(xiàng)（0710RJZA037），稀土配合物抗腫瘤作用分子機(jī)理研究，2008.1-2009.12
3. 主持蘭州市科技計(jì)劃資助項(xiàng)目一項(xiàng)（1208RJZA231）異甘草素抗腫瘤血管生成的機(jī)制研究，2007.1-2008.12
4. 主持企事業(yè)單位委托項(xiàng)目，戊肝疫苗臨床前重復(fù)給藥，毒性試驗(yàn)，2005.11-2007.6
5. 主持企事業(yè)單位委托項(xiàng)目，蛇葡萄素抗腫瘤作用的研究，2006.4-2007.12
6. 主持蘭州大學(xué)醫(yī)學(xué)基金一項(xiàng)，稀土配合物抗腫瘤作用及機(jī)理研究，2007.1-2008.12
7. 主持甘肅省新藥臨床前研究重點(diǎn)實(shí)驗(yàn)室開放課題基金一項(xiàng)，二（2-吡啶基-N-氧化物）二硫化物鑭稀土配合物的抗腫瘤作用及機(jī)理研究，2006.1-2008.12
參與科研項(xiàng)目情況：
1.  以項(xiàng)目組主要成員（2/9）參與國家自然科學(xué)基金委——面上項(xiàng)目一項(xiàng)，填充吸附微量萃取法結(jié)合細(xì)胞代謝組學(xué)研究金納米材料的毒性，2014.1-2017.12
2.  以項(xiàng)目組主要成員（2/4）參與甘肅省自然基金項(xiàng)目一項(xiàng)，抗病毒藥篩選模型的建立及抗病毒中藥，2004.7-2006.12
 
發(fā)表論文

Publications
1. Xiaoyu Zhang, Ping Zhu, Xiuying Zhang, Yina Ma, Wenguang Li, Ji-Mei Chen,Hui-Ming Guo, Richard Bucala, Jian Zhuang, and Ji Li. Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway. Mediators of Inflammation. Volume 2013, Article ID 390890, 10 pages.(SCI, IF2013 = 3.882)
2. XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247–1257. (SCI)
3. XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309–318. (SCI)
4. XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043–1052. (SCI)
5. Xiaoyu ZHANG, Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533–538. (SCI)
6. XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432–438. (SCI)
7. Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract) (SCI)
8. Xiaoyu Zhang, Eddie D Yeung, Jingying Wang, Evgeniy E Panzhinskiy, Tong Chao, Wenguang Li, Ji Li. Natural antioxidant-Isoliquiritigenin selectively inhibits growth of prostate cancer cells. Clin. Exp. Physiol. Pharm. 2010; 37: 841–847 (SCI)
9. WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941–949. (SCI)
10.LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727–732. (SCI)
11.LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI)
12.ZHANG XiaoYu, ZHENG TianZhen and PANG JinJiang. Effects of progesterone on contractile activity of trachea smooth muscle in rabbits. Chin J Appl Physiol. 2003; 19(4): 388, 401. (CSCD)
13.ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI　Ｗei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386. (CSCD)
14.ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16 (CSCD)
15.ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extract in vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120.
16.ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J Lanzhou University ( Natural Sci). 2004; 40Supp: 34–36. (CSCD)
17.ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17. (CSCD)
18.Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract)
19.Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179-188. (SCI)
20.Zheng-lan Han, Zi-long Wang, Hong-zhu Tang, Ning Li, Quan Fang*, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, Rui Wang* .Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behav Brain Res. 2013; 248; 51-56. (SCI)
21.SI JinChao, ZHANG XiaoYu, LIN MeiLing, DING YongHui, LI Mei, QU SongYi and ZHENG TianZhen. Effects of Ephedra on body mass, serum lipid, glucose and hormone level of ovarietomized obese rats. Chin J Clin Rehabilit. 2006; 10(47): 209–212. (CSCD)
22.LI WenGuang, ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424. (CSCD)
23.Jingying Wang, Heng Ma, Xiaoyu Zhang, Leilei He, Jianming Wu, Xiaoping Gao, Jun Ren, Ji Li. A Novel AMPK Activator from Chinese Herb Medicine and Ischemia Phosphorylate the Cardiac Transcription Factor FOXO3. Int J Physiol Pathophysiol Physiol. 2009: 1: 116-126 (SCI)
24.Peng Zhao, Jingying Wang, Leilei He, Heng M, Xiaoyu Zhang, Xinglei Zhu, E. Kurt Dolence, Jun Ren, Ji Li. Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia. J. Cell. Mol. Med. 2009; 13: 1513–1525 (SCI)
25.Wang Jun, Wang Hao, Guo Zhen, ZHANG XiaoYu, QU SongYi and ZHENG TianZhen. Gastrodin in modulating body mass and metabilism in obese rats fed with high-fat diet. J Clin Rehabilit. Tissue Engineering Res. 2008; 12(207): 3992–3996. (CSCD)
26.Guo Jiaohong, Li Xujun, Yue Jia, ZHANG XiaoYu, Lin Meiling and ZHENG TianZhen. The effects of Radix Achykanthis Bidentatae from Henan of China on body weight and tumor Necrosis Factor-α in ovariectomized obese rats. J Chengdu Medical College 2008; 3(2): 100–102, 106.
27.Li Xujun, Yue Jia, Chang Yanqin, Lin Meiling, ZHANG XiaoYu, Ding Yonghui and ZHENG TianZhen. Effects of Rhizoma Wenyujin Concisum on ovariectomized obese rats. China J Modern Med. 2008; 18(4): 405–407, 412. (CSCD)
28.袁良杰，盧霞，王君，鄭天珍，瞿頌義，張小郁*. 苦參堿對(duì)高脂肥胖大鼠體重、血脂和抗過氧化能力的影響. 時(shí)珍國醫(yī)國藥. 2008; 19（9）: 2062-2064（*為通訊作者）(CSCD)
29.白 巖，盧伍黨，李文廣，張小郁*. 金屬配合物Cu(Ⅱ)1-羥基-3-（2-環(huán)氧基）噸酮的體外抗腫瘤作用. 蘭州大學(xué)學(xué)報(bào)（醫(yī)學(xué)版）. 2010; 36(2): 56-60 （*為通訊作者）
30.白 巖，盧伍黨，李文廣，張小郁*. 金屬配合物Cu(Ⅱ)噸酮冠醚的體外抗腫瘤作用. 蘭州大學(xué)學(xué)報(bào)（醫(yī)學(xué)版）. 2010; 36(3): 21-25（*為通訊作者）
31.黃征，張林，瞿頌義， 鄭天珍，張小郁*. 天麻素對(duì)大鼠離體脂肪組織釋放游離脂肪酸及抗氧化作用的影響. 第四軍醫(yī)大學(xué)學(xué)報(bào)(J. Fourth Mil. Univ.). 2009：30（16）：1488-1490. （*為通訊作者）(CSCD)
32.朱家恩，白延斌，藺美玲，鄭天珍，瞿頌義，丁永輝，張小郁*.白芍對(duì)去卵巢大鼠體重、血脂及抗氧化能力的影響.中國老年學(xué)雜志，2009, 29(2): 135-137 （*為通訊作者）(CSCD)
33.趙麗，陳紅梅，藺美玲，劉世雄，李中平，王志強(qiáng)，張小郁*，鄭天珍.原花青素對(duì)STZ致胰島細(xì)胞損傷的保護(hù)作用. 中國老年學(xué)雜志，2011, 31(23): 4580-4582 （*為通訊作者）(CSCD)
34.李中平，任文輝，張寶麗，藺美玲，陳紅梅，趙麗，王志強(qiáng)，張小郁*.檳榔堿對(duì)STZ致INS-1細(xì)胞損傷的保護(hù)和修復(fù)作用. 中國老年學(xué)雜志，2011, 31(23): 4583-4585 （*為通訊作者）(CSCD)
35.王志強(qiáng)，黃雙盛，劉圓圓，胡臘梅，李文廣，侯翠蘭, 張小郁*。異甘草素的抗腫瘤血管生成作用.中國科技論文在線, 2012（*為通訊作者）
 
學(xué)術(shù)兼職：

中國生理學(xué)會(huì)消化內(nèi)分泌生殖代謝生理專業(yè)委員會(huì)  委員
甘肅省生理科學(xué)學(xué)會(huì)  理事
甘肅省新藥臨床前研究重點(diǎn)實(shí)驗(yàn)室  成員