2021年南通大學醫學院醫學生物化學與分子生物學調劑信息

2025考研復試標準班

2025考研復試特訓班【1v1個性批改+模擬面試+聽口糾音】

 一、課題組介紹

秘曉林，博士，教授，博士研究生導師。入選中國科學院“引進國外杰出人才--百人計劃”、遼寧省“攀登學者”。國家自然科學基金、國家重大科學研究計劃、博士后科學基金、美國國家科學基金研究生項目等評議人，sci雜志international journal of
nanomedicine顧問編委，current proteomics、plos one編委，中國生化藥物雜志編委，中國環境誘變劑學會理事，遼寧省醫學會醫學遺傳學分會副主任委員，biomaterials、genetics、international journal of nanomedicine等sci雜志審稿人。主持國家重點基礎研
究計劃“973”課題、國家自然科學基金項目、中國科學院創新項目等。

1990年畢業于蘭州大學生物化學專業，獲學士學位；1996年畢業于衛生部蘭州生物制品研究所免疫學和微生物學專業，獲碩士學位；1999年畢業于中國預防醫學科學院病原生物學專業，獲博士學位。同年赴美國，在國立衛生研究院（national institutes of health）國
家癌癥研究所（national cancer institute）從事博士后研究，隨后任職美國國立衛生研究院國家癌癥研究所研究學者。作為通訊作者，研究成果發表在proceedings of national academy of sciences usa、plos genetics、oncogene、biomaterials、human
molecular genetics等國際知名學術期刊。

研究方向

1.非編碼RNA應答DNA損傷，調節細胞周期、凋亡、轉錄的功能和機制；

2.腸道干細胞再生與分化的表觀遺傳調控。

代表性文章（*通訊作者）

1.dai z., li d. *, du x., ge y., hursh d.a., bi x. * drosophila caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. plos genetics. 2020. 16(10):e1009140.  if 5.4

2.li d., liu y., pei c., zhang p., pan l., xiao j., meng s., yuan z., bi x. * mir-285-yki/mask double-negative feedback loop mediates blood-brain barrier integrity in drosophila. proceedings of national academy of sciences usa. 2017. 114(12): e2365-e2374.  if 9.7

3.song f., li d. *, wang y., bi x.* drosophila caliban mediates g1-s transition and ionizing radiation induced s phase checkpoint. cell cycle. 2018. 17(18): 2256-2267.  if 3.3

4.yuan q., tian r., zhao h., li l., bi x. * multiple arginine residues are methylated in drosophila mre11 and required for survival following ionizing radiation. g3: genes genomes genetics. 2018. 8 (6): 2099-2106.  if 2.7

5.li d. and bi x. * effect of teratogens on development of drosophila melanogaster. teratogenicity testing: methods and protocols. methods in molecular biology. springer. 2018. 1797:233-241.

6.cong, w., wang, p., qu, y., tang, j., bai, r., zhao, y., chen, c. *, bi, x. * evalutation of the influence of fullerenol on aging and stress resistance using caenorhabditis elegans. biomaterials. 2015. 42:78-86.  if 8.6

7.jiang k., liu m., lin g., mao b., cheng w., liu h., gal j., zhu h., yuan z., deng w., liu q., gong p., bi x. *, meng s. * tumor suppressor spred2 interaction with lc3 promotes autophagosome maturation and induces autophagy-dependent
cell death. oncotarget. 2016. 7 (18): 25652-25667.  if 5.2

8.chen, h., wang, b., feng, w. *, du, w., ouyang, h., chai, z., bi, x.*  oral magnetite nanoparticles disturb the development of drosophila melanogaster from oogenesis to adult emergence. nanotoxicology. 2015. 9(3):302-312.  if 7.9

9.yuan, q., han, j., cong, w., ge, y., ma, d., dai, z., li, y. *, bi, x. * docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced
myelosuppression toxicity. international journal of nanomedicine. 2014.  9(1): 4829-4846.  if 4.3

10.fang, g., zhang, d., yin, h., zheng, l., bi, x.*, yuan, l.*  centlein maintains centrosome cohesion by bridging an interaction between c-nap1 and cep68. journal of cell science. 2014.  127 :1631-1639.  if 5.4

11.wang, y., wang, z., joshi, bh., puri, r., stultz, b., yuan, q., bai, y., zhou, p., yuan, z., hursh, da., bi, x.* the tumor suppressor caliban regulates dna damage induced apoptosis through p53-dependent and ╟independent activity.
oncogene. 2013. 32(33):3857-66.  if 8.6

12.liu, w., jiang, f., bi, x.*, zhang, q*. drosophila fmrp participates in dna damage response by regulating g2/m cell cycle checkpoint and apoptosis. human molecular genetics. 2012, 21(21):4655-68.  if 7.7

13.kong, l., yuan y., zhu, h., li, y., guo, q., zhao, y., wang, q., bi, x.*, gao,x*. the suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis. biomaterials. 2011.32(27)：
6515-6522.  if 7.6

14.wang, p., bai, y., song, b., wang, y., liu, d., lai, y., bi, x.*, yuan, z*. pp1a-mediated dephosphorylation positively regulates yap2 activity. plos one. 2011.6(9):e24288.  if 4.1

15.gao, g., bi, x., chen, j., srikanta, d., rong, ys. mre11-rad50-nbs complex is required to cap telomeres during drosophila embryogenesis. proceedings of national academy of sciences usa. 2009. 106(26): 10728╟10733.(equal
contribution).  if 9.4

16.bi, x., jones, t., abbasi, f., lee, h., stultz, b., hursh, d., mortin, m. drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. oncogene. 2005. 24:8229-8239.  if 6.8

17.bi, x., srikanta, d., fanti,l., pimpinelli,s., badugu,r., kellum,r., rong, y.s. * drosophila atm and atr checkpoint kinases control partially redundant pathways for telomere maintenance. proceedings of national academy of sciences
usa. 2005. 102(42):15167-15172.  if 10.2

18.bi, x., gong, m., srikanta, d., rong, y.s. * drophila atm and mre11 are essential for the g2/m checkpoint induced by low-dose irradiation. genetics. 2005. 171:845-847.  if 4.4

19.bi, x., wei, s.d., rong, y.s. * telomere protection without a telomerase: the role of atm and mre11 in drosophila telomere maintenance. current biology. 2004. 14:1348-1353.  if 11.9

20.bi, x., kajava, a., demidenko, z., jones, t., mortin, m. * the carboxyl terminus of prospero regulates its subcellular localization.  molecular and cellular  biology.  2003. 23 (3): 1014-1024.  if 8.9

二、招收條件和招生專業

符合我校2021年攻讀碩士學位研究生招生簡章要求，初試成績達到全國一類地區碩士研究生初試分數線的普通全日制本科考生。要求生命科學背景，對科研有濃厚興趣，勤于思考，能夠閱讀英語專業文獻，具備團隊精神。

招生院系：醫學院。

招生專業：醫學生物化學與分子生物學  1001z2。

有攻讀博士意向的考生優先考慮。

2025考研復試標準班

2025考研復試特訓班【1v1個性批改+模擬面試+聽口糾音】

2025考研復試伴學班·【初試不過，協議退費】