中國(guó)藥科大學(xué)藥學(xué)院研究生導(dǎo)師介紹：楊勁

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楊勁，中國(guó)藥科大學(xué)藥代中心，教授，博士。

1993年畢業(yè)留校后一直從事藥代動(dòng)力學(xué)研究和教學(xué)工作20余年，期間在國(guó)家藥品審評(píng)中心外聘工作近一年。現(xiàn)為國(guó)家藥品審評(píng)專家，江蘇省藥品審評(píng)專家，中國(guó)定量藥理藥理學(xué)會(huì)委員。

1、招生方向：

藥代動(dòng)力學(xué)；

2、研究特色

數(shù)學(xué)建模與仿真。應(yīng)用于創(chuàng)新藥物的早期臨床探索研究，兒童給藥方案探索研究，生物類似物評(píng)價(jià)研究，已上市藥物的個(gè)體化給藥研究。

3、科研成果：

評(píng)估創(chuàng)新藥物20余個(gè)，其中有多個(gè)已經(jīng)獲得上市許可。

發(fā)表SCI論文20余篇，影響因子大于50。發(fā)表新藥審評(píng)技術(shù)論文多篇。發(fā)表中文核心雜志論文50余篇。

主持并承擔(dān)多項(xiàng)國(guó)家自然科學(xué)基金、國(guó)家重大新藥創(chuàng)制專項(xiàng)。近幾年科研經(jīng)費(fèi)累積超過(guò)500萬(wàn)元。

4、聯(lián)系方式

cpu_yj@163.com

5、近幾年發(fā)表代表性論文：

1)Fan G, Cao Y, Yang J(Correspondence Author). In vitro inhibition and induction of human cytochrome P450 enzymes by SIPI5357, a potential antidepressant. Biopharm Drug Dispos. 2015 Mar 16. doi: 10.1002/bdd.1947
2)Jing Z, Kuang L, Liu N, Yang J(Correspondence Author). LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics. Bioanalysis. 2015 May;7(10):1261-71. doi: 10.4155/bio.15.58.
3)Xu R, Liu X, Yang J(Correspondence Author). A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population. PLoS One. 2014 Dec 2;9(12): e114049. doi: 10.1371/journal.pone.0114049. eCollection 2014
4)Biao Yu, Pengcheng Ma, Linwen Yuan, Dingding Chen, and Jin Yang∗(Correspondence Author) Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug–drug interaction for transdermal drug delivery in miniature pig. Xenobiotica. 2014 Nov 20:1-5.
5)Xu R, Wang Q, Zhang J, Zang M, Liu X, Yang J(Correspondence Author). Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica. 2014 Jun;44(6):541-6.
6)Min Zang, Xiaoqiang Liu, Lin Chen, Qingqing Xiao, Linwen Yuan, Jin Yang∗(Correspondence Author)  Determination of BmKCT-13, a chlorotoxin-like peptide, in rat plasma by LC–MS/MS: Application to a preclinical pharmacokinetic study Journal of Chromatography B, 947–948 (2014) 125– 131
7)Liqing Kuang, Zhiqiang Jing, Jing Wang, Liyuan Ma, Xiaoqiang Liu, Jin Yang (Correspondence Author) Quantitative determination of ε-N-Carboxymethyl-L-lysine in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis(IF=2.97) Journal of Pharmaceutical and Biomedical Analysis 90 (2014) 1–6
8)Shuming LI, Xiangyang WANG, Wei LI, Yang CHU. Jiahua GUO, Xiaohui MA, Jin YANG (Correspondence Author) Characterization of Metabolites in Rat after Administration of Danshensu by Liquid Chromatography-tandem Mass Spectrometry Lat. Am. J. Pharm. 2013:32 (4): 582-6
9)Yuan Lu • Jinbo Yang • Haiyan Zhang • Jin Yang. (Correspondence Author) Prediction of Warfarin Maintenance Dose in Han Chinese Patients Using a Mechanistic Model Based on Genetic and Non-Genetic Factors. Clinical Pharmacokinetics(IF=5.40). (2013) 52:567–581
10)R. Xu, Q. Xiao, Y. Cao, J.Yang(Correspondence Author) Comparison of the Exposure of Glycyrrhizin and its Metabolites and the Pseudoaldosteronism after Intravenous Administration of Alpha- and Beta-glycyrrhizin in Rat. Drug Res (Stuttg). 2013 Jul 17
11)Xu R, Zhang X, Yang J(Correspondence Author), Liu X, Davey AK, Wang J. Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats. Biopharm Drug Dispos(IF=2.07). 2012 Apr 17. doi: 10.1002/bdd.1789.
12)Min Zhang, Jin Yang(Correspondence Author), Lei Tao, Lingjun Li, Pengcheng Ma, and John Paul Fawcett, Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters AAPS J(IF=5.09). 2012 Jun;14(2):345-51.
13)Feng-Juan Zhao, Hong Tang, Qing-Hua Zhang, Jin Yang, (Correspondence Author), Andrew K., Daveyc, Ji-ping Wang. Salting-out homogeneous liquid–liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC–MS Journal of Chromatography B(IF=2.89), 881–882 (2012) 119– 125
14)Guo-fu LI, Kun WANG, Rui CHEN, Hao-ru ZHAO, Jin YANG, Qing-shan ZHENG, Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal  function using whole-body physiologically based pharmacokinetic modeling. Acta Pharmacologica Sinica (2012) 33: 1359–1371
15)Chen Yanxiao Xu Ruijuan Yang Jin(Correspondence Author) Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats Life Sciences 89 (2011) (IF=2.56)1–6
16)Xiong Yu ; Yang yuqing ; Yang jin, Dr.; chai hong yan; Li ying; Yang Jing , Dr. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanolinduced liver steatosis in mice， Toxicology. 2010 Sep 30;276(1):64-72.
17)Qing-Hua Zhang, Jin Yang(Correspondence Author) Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers  Arzneimittelforschung 2010;60(10):640–644
18)L. Chen, J. Yang(Correspondence Author), A. K. Davey, Y.-X. Chen, J.-P. Wang, and X.-Q. Liu Efects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism Xenobiotica(IF=1.918), 2009; 39(12): 955–963
19)Jin Yang, Ying He Pharmacokinetic Properties of S-adenosylmethionine after Oral and intravenous administration of its Tosylate disulfate salt: a Multiple-dose, Open-Label, Parallel-Group study in Healthy Chinese volunteers Clinical Therapeutics Volume 31, Number 2, 2009 (IF=3.261)：311-320
20)Jin Yang, Liang Zhou, JipingWang, GuangjiWang, Andrew K Davey The Disposition of Diammonium Glycyrrhizinate and Glycyrrhetinic Acid in the Isolated Perfused Rat Intestine and Liver   Planta Medica 2008; 74: 1351–1356
21)袁淋文楊勁（通訊作者）Beagel犬藥動(dòng)學(xué)研究在緩釋制劑評(píng)價(jià)體系中的作用比較.中國(guó)新藥雜志2015年第24卷第10期:1134-1140
22)趙明，楊勁（通訊作者），魏敏吉置信區(qū)間法用于線性藥代動(dòng)力學(xué)特征評(píng)價(jià).中國(guó)臨床藥理學(xué)雜志2015年2月：238-240
23)趙明，謝松梅，楊勁（通訊作者），魏敏吉.關(guān)于生物等效性試驗(yàn)中血藥峰濃度等效界值的思考中國(guó)臨床藥理學(xué)雜志2014年10月：970-973
24)陳曉媛楊勁關(guān)于甲磺酸伊馬替尼口服制劑生物等效性試驗(yàn)設(shè)計(jì)的幾點(diǎn)考慮中國(guó)臨床藥理學(xué)雜志2014年9月：840-843
25)肖青青趙鳳娟楊勁（通訊作者）王友群藥物分布容積的預(yù)測(cè)方法中國(guó)藥科大學(xué)學(xué)報(bào)2013年第03
26)何清楊勁（通訊作者）；數(shù)字胃腸道模型的建立及在硝苯地平緩釋片人體吸收預(yù)測(cè)中的應(yīng)用中國(guó)藥科大學(xué)學(xué)報(bào)2012(01):85-91.
27)陳春，林志強(qiáng)，楊勁(通訊作者)模型設(shè)計(jì)在制劑研發(fā)及生產(chǎn)過(guò)程質(zhì)量控制中的應(yīng)用?《藥學(xué)進(jìn)展》2011年第35卷第7期289-296
28)尹雪芬林志強(qiáng)楊勁(通訊作者)基于轉(zhuǎn)運(yùn)蛋白的代謝性數(shù)字肝生理模型預(yù)測(cè)普伐他汀、匹伐他汀與環(huán)孢素的藥代動(dòng)力學(xué)相互作用藥學(xué)學(xué)報(bào)ActaPharmaceuticaSinica2011,46(9):1108−1116
29)黎國(guó)富,楊勁(通訊作者),華小懿,陳蕊,趙浩如Ussingchamber模型研究甘草酸二銨經(jīng)大鼠腸黏膜的轉(zhuǎn)運(yùn)特征中國(guó)中藥雜志2010;35(17);p2261-2266
30)黎國(guó)富楊勁(通訊作者)張雪瑩趙浩如基于胃腸道生理模型的口服藥物吸收預(yù)測(cè)中國(guó)臨床藥理學(xué)與治療學(xué)2010Jun;15(6):656–662
31)張雪瑩,楊勁(通訊作者)谷胱甘肽的肝臟轉(zhuǎn)運(yùn)及其在膽汁淤積中的作用藥學(xué)學(xué)報(bào)2009,44(4):1-6
32)汪音楊勁(通訊作者)傅繼華劉曉東王廣基基于體外模型數(shù)據(jù)模擬和預(yù)測(cè)人體內(nèi)群體藥代參數(shù)中國(guó)臨床藥理學(xué)與治療學(xué)2008年13卷5期：545-551
33)蘇笠楊勁(通訊作者)化合物脂水分配系數(shù)計(jì)算軟件及比較研究中國(guó)藥科大學(xué)學(xué)報(bào)2008，39（2）：178~182
34)周亮楊勁(通訊作者)，張雪瑩，柳曉泉，王廣基磷脂對(duì)甘草酸二銨小腸吸收的影響藥學(xué)學(xué)報(bào)2008年vol.43No.171~75