中國(guó)藥科大學(xué)生命科學(xué)與技術(shù)學(xué)院研究生導(dǎo)師介紹：孔毅

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孔毅,男，1968年4月出生，博士，中國(guó)藥科大學(xué)副教授，碩士研究生導(dǎo)師。

2001年獲中國(guó)藥科大學(xué)博士學(xué)位，2003年在南京大學(xué)與江蘇萬邦生化醫(yī)藥股份有限公司從事博士后研究工作。2010年5月-9月，英國(guó)帝國(guó)理工學(xué)院訪問學(xué)者；2012年10月-2013年11月，北卡羅萊納大學(xué)訪問學(xué)者。江蘇省青藍(lán)工程中青年學(xué)科帶頭人培養(yǎng)對(duì)象。

研究方向

1微生物藥物和生化與生物技術(shù)藥物的開發(fā)與應(yīng)用
2天然生化活性物質(zhì)及其功能基因的研究
探尋自然界中結(jié)構(gòu)新穎、生理活性強(qiáng)的天然多肽，并研究其結(jié)構(gòu)與功能的關(guān)系，為創(chuàng)新藥物研發(fā)服務(wù)。

主要研究技術(shù)包括:蛋白質(zhì)及多肽的分離純化，多肽的結(jié)構(gòu)分析，酶法及ELISA法活性篩選，體內(nèi)外抗血栓活性及分子作用機(jī)制研究，計(jì)算機(jī)輔助藥物設(shè)計(jì)等。

發(fā)明專利：

申請(qǐng)發(fā)明專利10余件，其中授權(quán)專利5件。

科研項(xiàng)目：

主持國(guó)家自然科學(xué)基金1項(xiàng),省級(jí)課題2項(xiàng),美國(guó)強(qiáng)生制藥課題1項(xiàng),企業(yè)課題6項(xiàng).參與國(guó)家自然科學(xué)基金2項(xiàng),重大新藥創(chuàng)制1項(xiàng)。

近五年發(fā)表論文(第一或通訊作者)

2015
Mei-Mei Chen, Xiao-Hui Ye, Xin Ming, Ya-Hui Chen, Ying Wang, Xing-Li Su, Wen Su and Yi Kong. A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates[J]. Scientific reports, 2015, 5.
Yi Kong, Ying Wang, Wei Yang, Zhou-Ling Xie, Zhi-Yu Li. LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa[J]. Journal of pharmacological sciences, 2015, 127(4): 462-466.
Xing-Li Su, Wen Su, Zhi-Long He, Xin Ming and Yi Kong. Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation via Affecting PI3K/Akt Signaling[J]. Journal of cardiovascular pharmacology, 2015.
Xiao-Hui Ye, Mei-Mei Chen, Ya-Hui Chen, Xing-Li Su, Ying Wang, Wen Su, Yi Kong. Isolation and Characterization of a Novel Antithrombotic Peptide from Enzymatic Hydrolysate of Agkistrodon acutus Venom[J]. International Journal of Peptide Research and Therapeutics, 1-9.
Guangyan Cheng, Liying He, Zhibin Sun, Zhongli Cui, Yingxiang Du, Yi Kong. Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3[J]. Journal of microbiology and biotechnology, 2015.
 
2014
Yi Kong, Cheng Xu, Zhi-Long He, Qiu-Mei Zhou, Jin-Bin Wang, Zhi-Yu Li, Xin Ming. A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus[J]. Peptides, 2014, 53: 70-78.
Yi Kong, Shuai Li, Yu Shao, Zhi-Long He, Mei-Mei Chen, Xin Ming, Ji-Fu Wei. Antithrombotic Peptides from Scolopendra subspinipes mutilans Hydrolysates[J]. International Journal of Peptide Research and Therapeutics, 2014, 20(2): 245-252.
Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng and Ji-Fu Wei. Direct thrombin inhibitors: Patents 2002-2012 (Review)[J]. Molecular medicine reports, 2014, 9(5): 1506-1514.
Hao Chen, Min Jin, Yi-Fen Wang, Yong-Qing Wang, Ling Meng, Rong Li, Jia-Ping Wang, Li Gao, Yi Kong and Ji-Fu Wei. Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System[J]. BioMed research international, 2014
 
2013
Yi Kong, Yu Shao, Hao Chen, Xin Ming, Jin-Bin Wang, Zhi-Yu Li, Ji-Fu Wei. A novel factor Xa-inhibiting peptide from centipedes venom[J]. International journal of peptide research and therapeutics, 2013, 19(4): 303-311.
Yi Kong, Jing Hui, Yu Shao, Shi-Long Huang, Hao Chen and Ji-Fu Wei. Cytotoxic and anticoagulant peptide from Scolopendra subspinipes mutilans venom[J]. African J Pharm Pharmacol, 2013, 7: 2238-2245.
Yi Kong, Shi-Long Huang, Yu Shao, Shuai Li, Ji-Fu Wei. Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans[J]. Journal of ethnopharmacology, 2013, 145(1): 182-186.
 
2012
Jing Xiong, Li Bai, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong, Yunman Li. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation[J]. European Journal of Pharmaceutical Sciences, 2012, 45(5): 552-558.
 
2011
Hongwen Zhao, Yi Kong, Hanjin Wang, Tianhua Yan, Feifei Feng, Jianmin Bian, Yan Yang and Haining Yu. A defensin‐like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana[J]. Journal of Peptide Science, 2011, 17(7): 540-544.

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