江南大學(xué)生物工程學(xué)院碩士生導(dǎo)師介紹：藤田盛久

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性別：男
出生年月：1979年5月4日
職稱、職務(wù)：教授
電話：
電子郵箱：fujita@jiangnan.edu.cn
【學(xué)術(shù)簡介】

教育背景：
2004-2006日本筑波大學(xué)生命環(huán)境科學(xué)研究科獲博士學(xué)位
2002-2004日本筑波大學(xué)生命環(huán)境科學(xué)研究科獲碩士學(xué)位
1998-2002日本筑波大學(xué)第二學(xué)群生物資源學(xué)類獲學(xué)士學(xué)位
工作經(jīng)歷：
2014-現(xiàn)在江南大學(xué)生物工程學(xué)院教授
2012-2014日本大阪大學(xué)微生物病研究所助理教授
2008-2012日本大阪大學(xué)微生物病研究所特任助理教授
2007-2008日本大阪大學(xué)微生物病研究所博士后
2006-2007瑞士日內(nèi)瓦大學(xué)生物化學(xué)學(xué)院博士后
2006-2006日本產(chǎn)業(yè)技術(shù)綜合研究所糖鎖研究中心博士后
【研究領(lǐng)域】

多年來，藤田盛久博士致力于細(xì)胞分子生物學(xué)和生物化學(xué)的研究，尤其是糖生物學(xué)和分子遺傳學(xué)領(lǐng)域。特別是他在蛋白質(zhì)糖脂翻譯后修飾術(shù)語也叫做GPI錨定化的生理功能研究中的突出貢獻。他鑒定出并分析了GPI錨結(jié)構(gòu)重構(gòu)中的關(guān)鍵基因。目前，他把目標(biāo)放在具有生物學(xué)和醫(yī)學(xué)意義的重要糖蛋白胞內(nèi)轉(zhuǎn)運過程的研究。為了深入了解該過程，運用遺傳學(xué)方法，細(xì)胞生物學(xué)和生物化學(xué)等技術(shù)綜合的在動物細(xì)胞和酵母細(xì)胞中開展研究。
【主要論著】（著作和論文）

OriginalPapers
１.Theiler,R.,Fujita,M.,Nagae,M.,Yamaguchi,Y.,Maeda,Y.,andKinoshita,T.:
Theα-HelicalRegioninp24γ2Subunitofp24ProteinCargoReceptorIsPivotalfortheRecognitionandTransportofGlycosylphosphatidylinositol-anchoredProteins.
J.Biol.Chem.,289:16835-16843(2014)
２.Hirata,T.,Fujita,M.,Kanazawa,N.,Murakami,Y.,Maeda,Y.,andKinoshita,T.:
GlycosylphosphatidylinositolmannosyltransferaseIIistherate-limitingenzymeinglycosylphosphatidylinositolbiosynthesisunderlimiteddolichol-phosphatemannoseavailability.
J.Biochem.,154:257-264(2013)
３.Kanzawa,N.,Shimozawa,N.,Wanders,R.J.,Ikeda,K.,Murakami,Y.,Waterham,H.R.,Mukai,S.,Fujita,M.,Maeda,Y.,Taguchi,R.,Fujiki,Y.,andKinoshita,T.:
DefectivelipidremodelingofGPIanchorsinperoxisomaldisorders,Zellwegersyndrome,andrhizomelicchondrodysplasiapunctata.
J.LipidRes.,53:653-663(2012)
４.Fujita,M.,Watanabe,R.,Jaensch,N.,Romanova-Michaelides,M.,Satoh,T.,Kato,M.,Riezman,H.,Yamaguchi,Y.,Maeda,Y.,andKinoshita,T.:
SortingofGPI-anchoredproteinsintoERexitsitesbyp24proteinsisdependentonremodeledGPI.,
J.CellBiol.,194:61-75(2011)
５.Nakano,Y.,Fujita,M.,Ogino,K.,Kinoshita,T.,Oda,Y.,andHirata,H.:
BiogenesisofGPI-anchoredproteinsisessentialforsurfaceexpressionofsodiumchannelsinzebrafishRohon-Beardneuronstorespondtomechanosensorystimulation.,
Development,137:1689-1698　(2010)
６.Adachi,A.,Kano,F.,Tsuboi,T.,Fujita,M.,Maeda,Y.,andMurata,M.:
Golgi-associatedGSK3{beta}regulatesthesortingprocessofpost-Golgimembranetrafficking.,
J.CellSci.,123:3215-3225　(2010)
７.Fujita,M.,Maeda,Y.,Ra,M.,Yamaguchi,Y.,Taguchi,R.,andKinoshita,T.:
GPIglycanremodelingbyPGAP5regulatestransportofGPI-anchoredproteinsfromtheendoplasmicreticulumtotheGolgi.,
Cell,139:352-365(2009)
８.Hirayama,H.,Fujita,M.,Yoko-o,Y.,andJigami,Y.:
O-mannosylationisrequiredfordegradationoftheendoplasmicreticulum-associateddegradationsubstrateGas1*pviatheubiquitin/proteasomepathwayinSaccharomycescerevisiae.,
J.Biochem.,143(4):555-67(2008)
９.Umemura,M.,Fujita,M.,Yoko-o,Y.,Fukamizu,A.,andJigami,Y.:
SaccharomycescerevisiaeCWH43isinvolvedintheremodelingofthelipidmoietyofGPIanchorstoceramides.,
Mol.Biol.Cell,18(11):4304-16(2007)
１０.Maeda,Y.,Tashima,Y.,Houjou,T.,Fujita,M.,Yoko-o,T.,Jigami,Y.,Taguchi,R.,andKinoshita,T.:
FattyacidremodelingofGPI-anchoredproteinsisrequiredfortheirraftassociation.,
Mol.Biol.Cell,18(4):1497-506(2007)
１１.Fujita,M.,Umemura,M.,Yoko-o,T.,andJigami,Y.:
PER1isrequiredforGPI-phospholipaseA2activityandinvolvedinlipidremodelingofGPI-anchoredproteins.,
Mol.Biol.Cell,17(12):5253-64(2006)
１２.Fujita,M.,Yoko-o,T.,andJigami,Y.:
InositoldeacylationbyBst1pisrequiredforthequalitycontrolofglycosylphosphatidylinositol-anchoredproteins.,
Mol.Biol.Cell,17(2):834-50(2006)
１３.Fujita,M.,Yoko-o,T.,Okamoto,M.,andJigami,Y.:
GPI7involvedinglycosylphosphatidylinositolbiosynthesisisessentialforyeastcellseparation.,
J.Biol.Chem.,279(50):51869-79(2004)
ReviewsandBooks
１.Kinoshita,T.,Maeda,Y.andFujita,M.:
Transportofglycosylphosphatidylinositol-anchoredproteinsfromtheendoplasmicreticulum.
Biochim.Biophys.Acta–Mol.CellRes.,inpress(2013)
２.Fujita,M.:
PotentialRolesofGPI-AnchorRemodelinginProteinTraffickingandRaftAssociationinMammalianCells,
TrendsGlycosci.Glycotech.,24:244-257(2012)
３.Fujita,M.*andKinoshita,T.(*correspondingauthor):
GPI-anchorremodeling:PotentialfunctionsofGPI-anchorsinintracellulartraffickingandmembranedynamics.,
Biochim.Biophys.Acta,1821(8):1050-1058(2012)
４.Fujita,M.andKinoshita,T.:
StructuralremodelingofGPIanchorsduringbiosynthesisandafterattachmenttoproteins.,
FEBSLett.,584(9):1670-1677(2010)
５.Maeda,Y.,Fujita,M.,andKinoshita,T.:
GPI-Anchor:UpdateforBiosynthesisandRemodeling,
TrendsGlycosci.Glycotech.,22:182-193(2010)
６.Kinoshita,T.andFujita,M.:
OverviewofGPIbiosynthesis,
TheEnzymes,AcademicPress,26:1-30(2009)
７.Kinoshita,T.,Fujita,M.,andMaeda,Y.:
Biosynthesis,remodellingandfunctionsofmammalianGPI-anchoredproteins:recentprogress.,
J.Biochem.,144(3):287-94(2008)
８.Fujita,M.andJigami,Y.:
LipidremodelingofGPI-anchoredproteinsanditsfunction.,
Biochim.Biophys.Acta,1780(3):410-20(2008)
【科研項目】

2014年江蘇省自然科學(xué)基金青年基金
【科研成果及獎勵】

【榮譽與獎勵】

2012　YoungInvestigatorAwardofTheJapaneseBiochemicalSociety
2012　YoungInvestigatorAwardofTheJapaneseSocietyofCarbohydrateResearch
【在讀碩、博士人數(shù)】

碩士3名
【已畢業(yè)碩、博士人數(shù)】