湖南師范大學(xué)生命科學(xué)學(xué)院研究生導(dǎo)師介紹：張健

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湖南師范大學(xué)生命科學(xué)學(xué)院研究生導(dǎo)師張健介紹如下：

學(xué)習(xí)經(jīng)歷

1992年在美國(guó)邁阿密大學(xué)醫(yī)學(xué)院生物化學(xué)及分子生物學(xué)系獲博士學(xué)位。1993年在美國(guó)邁阿密大學(xué)醫(yī)學(xué)院醫(yī)學(xué)系從事博士后工作。

工作經(jīng)歷

1994年開(kāi)始，在美國(guó)耶魯大學(xué)分子、細(xì)胞及發(fā)育生物學(xué)系先后從事博士后和研究員工作。2000年回國(guó)受聘為湖南師范大學(xué)生命科學(xué)學(xué)院教授、博士生導(dǎo)師。2000年8月入選教育部“長(zhǎng)江學(xué)者獎(jiǎng)勵(lì)計(jì)劃” 特聘教授，同時(shí)獲國(guó)家杰出青年科學(xué)基金資助，2004年入選百千萬(wàn)人才工程國(guó)家級(jí)人選和享受政府特殊津貼，并受聘為上海“模式生物”E-研究院特約研究員，上海第二醫(yī)科大學(xué)兼職博士生導(dǎo)師。現(xiàn)為湖南省衛(wèi)生廳廳長(zhǎng)、政協(xié)湖南省第十屆委員會(huì)常務(wù)委員、九三學(xué)社湖南省委副主委、全國(guó)青聯(lián)留學(xué)人員聯(lián)誼會(huì)理事、湖南省知識(shí)分子聯(lián)誼會(huì)副會(huì)長(zhǎng)、國(guó)家遺傳工程小鼠資源庫(kù)第一屆技術(shù)委員會(huì)委員。
主要從事與人類(lèi)疾病相關(guān)的基因及蛋白的鑒定和功能分析。主持國(guó)家863計(jì)劃、國(guó)家“973”計(jì)劃、國(guó)家杰出青年基金、國(guó)家自然科學(xué)基金、教育部創(chuàng)新團(tuán)隊(duì)、教育部重點(diǎn)課題、湖南省教育廳重點(diǎn)項(xiàng)目、湖南省自然科學(xué)基金等多項(xiàng)課題等科研項(xiàng)目20余項(xiàng)；申請(qǐng)專(zhuān)利5項(xiàng)，已授權(quán)2項(xiàng)；在Nature、PNAS、Nucleic Acids Research等國(guó)際雜志上發(fā)表SCI論文30余篇；2001年獲得湖南省青年科技獎(jiǎng)。

代表性論著

1.Yingli Zhong, Jiaolian Zhu, Yan Wang, Jianlin Zhou, Kaiqun Ren, Xiaofeng Ding, Xiang Hu, Jian Zhang*(2009) LIM domain protein TES changes its conformational states in different cellular compartments. Mol Cell Biochem. 320:85-92
2.Xiao-Feng Ding,Chang Luo,JianLin Zhou, Yingli Zhong, Xiang Hu, Fangliang Zhou,Kaiqun Ren,Lu Gan,Ailan He,Jiaolian Zhu,Xiang Gao,and Jian Zhang（2009）The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation, Journal of Cellular Biochemistry, 106(2): 285-95
3.Rushi Liu, Aidong Zhou, Daolong Ren, Wenfeng Zhang ,Liping Yang, Mingjun Liu, Hong Li,Jianlin Zhou,Jian Zhang(2009)Transcription Factor Specificity Protein1 (SP1) and Activating Protein 2alpha Regulate Expression of Human KCTD10 by Binding to Proximal Region of the Promoter,FEBS Letter, 276（4）1114 – 1124
4.Xiaoning Peng, Xiaomin Zeng,Sihua Peng, Defeng Deng, Jian Zhang(2009)The Association Risk of Male Subfertility and Testicular Cancer: A Systematic Review,PLOS One,4(5)e5591
5.Hong Li,Qian Liu,Xiang Hu,Du Feng,Shuanglin Xiang,Zhicheng He,Xingwang Hu,Jianlin Zhou,Xiaofeng Ding,Chang Zhou,Jian Zhang(2009)Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator, Acta Biochim Biophys Sin41(7)535–544
6.He Ailan, Xiao Xiangwen, Ren Daolong, Gan Lu,Ding Xiaofeng, Qiao Xi,Hu Xingwang,Liu Rushi,Zhang Jian,Xiang Shuanglin(2009) Identification of target genes of transcription factor activator protein 2 gamma in breast cancer cells, BMC Cancer, 11(9):279
7．Lu GAN,Dong-xing ZHU,Li-ping YANG,Ru-shi LIU,Feng YAN, Jian ZHANG（2008）Involvement of transcription factor activator protein-2α in doxazosin-induced HeLa cell apoptosis,Acta Pharmacol Sin ; 29 (4): 465–472
8.Xiao-Feng Ding,Chang Luo,Kai-Qun Ren,Jing Zhang,Jian-Lin Zhou,Xiang Hu,Ru-Shi Liu,Yan Wang,Xiang Gao,and Jian Zhang（2008）Characterization and Expression of a Human KCTD1 Gene Containing the BTB Domain, Which Mediates Transcriptional Repression and Homomeric Interactions, DNA AND CELL BIOLOGY,27(5):257-265
9.Yan Wang,Haining Peng,Yingli Zhong,Daiqiang Li,Mi Tang,Xiaofeng Ding,Jian Zhang(2008)Differential gene expression profiling of HER2-overexpressing mammary tumor.Acta Biophys Sin,40（5）:365-373
10. Xiaofeng Ding，Changzheng Fan，Jianlin Zhou，Yingli Zhong，Rushi Liu, Kaiqun Ren，Xiang Hu，Chang Luo，Shunyong Xiao，Yeqi Wang，Du Feng and Jian Zhang* (2006) GAS41 interacts with transcription factor AP-2β  and stimulates AP-2β -mediated transactivation. Nucleic Acid Res. 34(9):2570-78.
11. Zhou JL, Fan CZ, Zhong YL, Liu YH, Liu MJ, Zhou AD, Ren KQ, Zhang J*. (2005). Genomic organization, promoter characterization and roles of Sp1 and AP-2 in the basal transcription of mouse PDIP1 gene. FEBS Letters, 579(7):1715-17.
12.Zhou J.L., Ren K.Q., Liu X., Xiong X.W., Hu X.X., Zhang J.* (2005) A novel PDIP1 related protein–KCTD10 that interacts with proliferating cell nuclear antigen and DNA polymerase . BBA,1729：200-203.
13. Zhou JL, Xiong XW, Hu XX, Jiang TS, Zhang J*. （2005）Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen，J. of Exp. Zoology, 303A(3):227-40.
14. ZHOU Jianlin, JIE Yucheng, JIANG Yanbo , ZHONG Yingli, LIU Yunhai and ZHANG Jian*（2005）. Development of simple sequence repeats (SSR) markers of ramie and comparison of SSR and inter-SSR marker systems. Progress in Natural Science，15(2): 137-142.
15. Jiang TS, Minunni M, Zhang J, Mascini M（2005）Detection of TP53 mutation using a portable Surface Plasmon Resonance DNA-based Biosensor. Biosensors and Bioelectronics, 20 (10): 1939-1945.
16.Zhang J, Sun Y, Liu Y, Sun Y and Liao DJ（2004） Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncology Reports,12(4):709-716
17.Zhang J, Brewer S, Huang J, Williams T（2003）Overexpression of transcription factor AP-2 alpha suppresses mammary gland growth and morphogenesis. Developmental Biology, 256(1):128-146
18.Zhang J and Williams T（2003）Identification and regulation of tissue-specific cis-acting elements associated with the human AP-2 gene. Developmental Dynamics, 228(2): 194-207.
19.Anand S, Wang WC, Powell DR, Bolanowski SA, Zhang J, Pawashe CL, Amemiya CT and Shashikant CS. (2003) Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes. Proc.Natl.Acad.Sci.USA 100: 15666-15669.