北京理工大學化學與化工學院研究生導師：馮旭東

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個人概況

特別副研究員, 博士生導師

招生專業：化學工程與技術（生物化工），

制藥工程，生物工程出生年月：1985 年 5 月

籍 貫：河北省

聯系方式

電 話：010-68914495

電子郵件：xd.feng@bit.edu.cn

工作單位：北京理工大學化學與化工學院工作地點：中關村校區 5 號教學樓

教育經歷

2010/04 – 2014/06，新西蘭奧克蘭大學，“化學與材料工程”博士 2007/09 – 2009/06，天津大學，化工學院，“生物化工”碩士 2003/09 – 2007/07，河北工業大學，化工學院，“生物工程”學士

工作經歷

2017/12– 至今， 北京理工大學，化學與化工學院，特別副研究員 2016/10 – 2017/11，北京理工大學，生命學院，特別副研究員 2014/07 – 2016/09，北京理工大學，生命學院，師資博士后

研究方向：酶工程、蛋白質工程、合成生物學

以植物天然產物合成過程中關鍵酶的挖掘、工程化改造及應用為主要研

究內容，利用蛋白質結構解析結合計算機模擬技術，研究酶的結構和功能之

間的構效關系；通過蛋白質工程手段對酶的穩定性、活性、底物特異性等方

面進行分子改造，獲得滿足工業化需求的高效酶制劑；通過構建無細胞催化

體系或微生物細胞工廠高效合成植物天然產物，利用生化反應工程及代謝工

程的策略對生物轉化過程進行強化，為實現其產業化提供理論指導。

在研項目

1.國家自然科學基金青年科學基金項目，21506011，人工設計糖基化調控酶耐熱性的研究，2016/01-2018/12，21 萬元，主持。

2.國家自然科學基金重點基金項目，21736002，微生物合成萜烯化合物過程中的跨膜轉運與代謝傳質強化，2018/01-2022/12，320 萬元，參與。

發表文章

1.Yujia Zhao, Bo Lv, Xudong Feng*, Chun Li*, Perspective on biotransformation and de novo biosynthesis of licorice constituents, Journal of Agricultural and Food Chemistry, 2017, 65: 11147-11156.

2.Xiaochen Liu, Liang Zhang, Xudong Feng, Bo Lv*, Chun Li, Biosynthesis of glycyrrhetinic acid-3-O-monoglucose using glycosyltransferase UGT73C11 from Barbarea vulgaris, Industrial & Engineering Chemistry Research, 2017, 56: 14949-14958.
3.Bo Lv, Hanli Sun, Shen Huang, Xudong Feng, Tao Jiang, Chun Li*. Structure-guided engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins. Journal of Biological Chemistry, 2018, 293, 433-443.

4.Xudong Feng, Heng Tang, Beijia Han, Bo Lv, Chun Li*. Engineering the thermostability of β-glucuronidase from Penicillium purpurogenum Li-3 by loop transplant. Applied Microbiology and Biotechnology, 2016. 100(23): 9955-9966.
5.Xudong Feng, Heng Tang, Beijia Han, Bo Lv, Chun Li*. Enhancing the thermostability of β-glucuronidase by rationally redesigning the catalytic domain

based on sequence alignment strategy. Industrial & Engineering Chemistry Research, 2016, 55, 5474−5483.
6.Bo Lv, Xiaogang Yang, Xudong Feng*, Chun Li. Enhanced production of glycyrrhetic acid 3-O-mono-β-D- glucuronide by fed-batch fermentation using pH and dissolved oxygen as feedback parameters. Chinese Journal of Chemical Engineering, 2016, 24(4): 506-512.
7.Haiyang Jia, Xiangying Sun, Huan Sun, Chenyi Li, Yunqian Wang, Xudong Feng, Chun Li*. Intelligent microbial heat-regulating engine (IMHeRE) for improved thermo-robustness and efficiency of bioconversion. ACS Synthetic Biology, 2016, 5(4): 321-320.

8.Zhe Li, Xiaoxiao Guo, Xudong Feng, Chun Li*. An environment friendly and efficient process for xylitol bioconversion from enzymatic corncob hydrolysate by adapted candida tropicalis. Chemical Engineering Journal, 2015. 263, 249-256.

9.Xiaoyan Wang, Yanli Liu, Chao Wang, Xudong Feng*, Chun Li*. Properties and structures of beta-glucuronidases with different transformation types of glycyrrhizin. RSC Advances, 2015. 5(84): 68345-68350.

10.Shen Huang, Xudong Feng*, Chun Li. Enhanced production of beta-glucuronidase from Penicillium purpurogenum Li-3 by optimizing fermentation and downstream processes. Frontiers of Chemical Science and Engineering, 2015. 9(4): 501-510.

11.Lifeng Qiao, Bo Lv, Xudong Feng, Chun Li*. A new application of aptamer: One-step purification and immobilization of enzyme from cell lysates for biocatalysis. Journal of Biotechnology, 2015. 203, 68-76.

12.Xudong Feng, Chun Li*. The improvement of enzyme properties and its catalytic engineering strategy. Progress in Chemistry, 2015. 27(11): 1649-1657.

13.Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Increasing reaction rate and conversion in the spinning cloth disc reactor: Investigating the effect of using multiple enzyme immobilized cloths. Chemical Engineering Journal, 2014.
255:356-364.

14.Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Characterization of liquid flow in the spinning cloth disc reactor: residence time distribution, visual study and modeling, Chemical Engineering Journal, 2014. 235: 356-367.

15.Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Enabling the utilization of wool as an enzyme support: enhancing the activity and stability of lipase immobilized onto woolen cloth, Colloids and Surfaces B: Biointerfaces, 2013.
102:526-533.

16.Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Characterization of tributyrin hydrolysis by immobilized lipase on woolen cloth using conventional batch and novel spinning cloth disc reactors, Chemical Engineering Research and Design, 2013. 91(9): 1684-1692.

17.Xudong Feng, DA Patterson, M Balaban, G Fauconnier, EAC Emanuelsson*. The spinning cloth disc reactor for immobilized enzymes: A new process intensification technology for enzymatic reactions, Chemical Engineering Journal, 2013. 221: 407-417.