重慶大學生物工程學院碩士生導師：李惠林

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重慶大學生物工程學院碩士生導師李惠林資料如下：

王亞洲，男，中美聯合培養博士，重慶大學生物工程學院教授，博導、院長助理。

基本信息：

出生年月:1979年09月

籍貫：湖南常德

職稱職務：教授、博士生導師；院長助理

社會兼職：中國生物材料學會會員，中國病理生理學會會員，中國生物醫學工程學會會員、中國生物醫學工程康復工程專業委員會青年委員

通信地址：重慶市沙坪壩區沙正街174號生物工程學院

郵政編碼：400044郵箱：yazhou_wang@cqu.edu.cn

教育與工作經歷：

1998.09-2002.07湘潭大學化學化工學院食品科學與工程專業學士

2002.09-2004.12重慶大學生物工程學院藥物化學專業碩士

2005.03-2009.12重慶大學生物工程學院生物醫學工程專業博士

2007.05-2008.08美國密蘇里大學哥倫比亞分校工程學院中美聯合培養博士

2009.12-2012.09重慶大學生物工程學院講師

2012.09-2017.09重慶大學生物工程學院副教授

2017.09-至今重慶大學生物工程學院教授

其中：

2013.06-2014.06掛職重慶大學研究生院院長助理

2017.01-2017.07英國紐卡斯爾大學訪問學者（生物力學研究領域）

2015.09-至今生物工程學院院長助理

研究興趣與方向：

1.新型納/微藥物遞送系統（特別是針對透血腦屏障給藥）；

2.生物材料的功能化改性及其在心血管領域的應用（特別是血管內支架等植介入材料）；

3.生物力學（特別是出血性腦卒中的生物力學問題）。

近年來以第一作者或通訊作者近年來發表的主要論文（*）

[1]Dan Zou, Wei Wang, Daoxi Lei, Ying Yin, Peng Ren, Jinju Chen, Tieying Yin, Bochu Wang, Guixue Wang,Yazhou Wang*.Penetrate blood-brain barrier and enable anti-tumor and nerve repair in glioma by DOX-loaded monosialoganglioside micelles system.International Journal of Nanomedicine2017, 12:4879-4889

[2]Sun W, Huang Y, Yin T*, Wang J, Du R, Qiu J, Zhang Y,Wang Y*, Chen J, Wang G. Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site.Biomaterials Science2017, 5(6), 1144-1155.

[3]Yazhou Wang, Guixue Wang*.Polymeric nanomicelles: a potential hazard for the cardiovascular system? Nanomedicine,2017, 12(12): 1355-1358 (Editorial article)

[4] Fei Fang, Dan Zou, Wei Wang, Ying yin, Tieying Yin, Shilei Hao, Bochu Wang, Guixue Wang,Yazhou Wang*. Non-invasive Approaches for Drug Delivery to the Brain Based on the Receptor Mediated Transport,Materials Science and Engineering C, 2017(76):1316-1327

[5]Yazhou Wang*, Wei Wang, Zong Li, Shilei Hao & Bochu Wang, A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress,Biomech Model Mechanobiol, 2016;15(5):1019-27

[6]Yazhou Wang*, Zong Li, Pengyu Shao, Shilei Hao, Wei Wang, Qian Yang, Bochu Wang，A novel multiple drug release system in vitro based on adjusting swelling core of emulsion electrospun nanofibers with core–sheath structure,Materials Science and Engineering C,2014(44):109–116.

[7]Yazhou Wang* , Yiqiong Zhang, Bochu Wang, Yang Cao, Qingsong Yu, Tieying Yin, Fabrication of core–shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying,J Nanopart Res,(2013) 15:1726

[8]Yazhou Wang*, Yiqiong Zhang, Pengyu Shao, Bochu Wang, Core-shell micro/nanoparticles containing multiple drugs fabricated by emulsion electrospraying,Journal of Controlled Release, 2013:172(1):e85–e86 (Abstract)

[9]Yazhou Wang, Guixue Wang, Liang Chen, Hao Li, Tieying Yin, Bochu Wang, James C-M Lee, Qingsong Yu. Electrospun nanofiber meshes with tailored architectures and patterns as potential tissue-engineering scaffolds,Biofabrication,2009 (1): 015001

[10]Yazhou Wang, Bochu Wang, Weili Qiao, Tieying Yin, A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles,Journal of Pharmaceutical Sciences, 2010.99(12):4805-4811

[11]Yazhou Wang, Bochu Wang, Guixue Wang, Tieying Yin, Qingsong Yu, A novel method for preparing electrospun fibers with nano-/micro-scale porous structures,Polymer Bulletin, 2009(63):259–265

[12]Yazhou Wang, Hao Li, Guixue Wang, Tieying Yin, Bochu Wang, Qingsong Yu, Electrospinning of polymer
nanofibers with ordered patterns and architectures.J. Nanosci. Nanotechnol.10, 1699-1706 (2010)

[13]Yazhou Wang, Weili Qiao, Bochu wang, Yiqiong Zhang, Pengyu Shao, and Tieying Yin Electrospun composite nanofibers containing nanoparticles for programmable release of dual drugs,Polymer Journal, 2011.43(5): 478-483

[14] Cao, Yang, Wang, Bochu,Wang, Yazhou, Lou, Deshuai, Polymer-controlled core-shell nanoparticles: a novel strategy for sequential drug release, RSC Advances, 2014, 4(57):30430-30439.

[15] Cao, Yang; Wang, Bochu;Wang, Yazhou; Lou, Deshuai, Dual Drug Release from Core-Shell Nanoparticles with Distinct Release Profiles, Journal of Pharmaceutical Sciences, 2014 ,103(10):3205-3216.

[16]Hao S, Wang B,Wang Y.Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control [J]. Materials Science and Engineering: C, 2015. doi:10.1016/j.msec.2014.12.029

[17]Hao S, Wang B,Wang Y.Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection [J]. Journal of Materials Chemistry B, 2015, 3(3): 417-431.

[18]Hao S,Wang Y,Wang B. Sinking-Magnetic Microparticles Prepared by the Electrospray Method for Enhanced Gastric Antimicrobial Delivery [J]. Molecular pharmaceutics, 2014, 11(5): 1640-1650.

[19]Hao S,Wang Y,Wang B, et al. Formulation of porous poly (lactic-co-glycolic acid) microparticles by electrospray deposition method for controlled drug release [J]. Materials Science and Engineering: C, 2014, 39: 113-119.

[20]Hao S, Wang B,Wang Y, et al. Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation [J]. Journal of nanoparticle research, 2014, 16(2): 1-11.

[21]Hao S,Wang Y, Wang B, et al. A novel gastroretentive porous microparticle for anti- Helicobacter pylori therapy: Preparation,in vitro and in vivoevaluation[J]. International journal of pharmaceutics, 2014, 463(1): 10-21.

[22]Shilei Hao,Yazhou Wang, Bochu Wang, Jia Deng, Xi Liu, Junyu Liu, Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery, Materials Science and Engineering C DOI:10.1016/j.msec.2013.07.009

[23]Lin Zhang,Yazhou Wang, Yang Cao, Deshuai Lou, Bochu Wang, Transport barriers and strategies of anti-tumor nanocarriers delivery system, Journal of Biomedical Materials Research: Part A 2013 DOI: 10.1002/jbm.a.34635

[24]Shilei Hao, Bochu Wang,Yazhou Wang,Liancai Zhu, Bin Wang, Tingwang Guo, Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method, Colloids and Surfaces B: Biointerfaces 108 (2013) 127– 133

[25]Deshuai Lou, Bochu Wang,Yazhou Wang, Yang Cao,Selective killing of cancer stem cells by a novel dual-targeting strategy,Medical Hypotheses 79 (2012) 430–432

[26]Wang B, Liu J, Ma LN, Xiao HL,Wang YZ, Li Y, Wang Z, Fan L, Lan C, Yang M, Hu L, Wei Y, Bian XW, Chen D, Wang J.Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44?gastric cancer cells via attenuating Wnt signaling.J Gastroenterol. 2013 Jul;48(7):798-808.

主持或參與的主要科研項目情況：

[1]國家重點基礎研究計劃（“973”）項目：“腦出血后血腫應力對豆紋動脈神經復合體結構與功能的影響及其機制研究（2014CB541603，子課題負責人）

[2]國家自然科學基金青年基金 基于腫瘤干細胞的始動性與可塑性構建時序性聯合給藥微納體系及其抗腫瘤效應的研究（31200713；2013-2015年）；項目負責人；

[3]重慶市自然科學基金 主動靶向腫瘤干細胞（CSCs）的聯合給藥微納粒構建與抗腫瘤效應研究（cstc2012jjA0549；2012-2015年）；項目負責人；

[4]教育部高等學校博士學科點科研基金(20120191120058；2013-2015年)項目負責人

[5]中央高校基本科研業務費重點項目基于腦重大疾病異常微環境下神經組織損傷機制與修復研究(2015CDJZR；2015-2017年)；項目負責人；

[6]國家科技支撐計劃 新型藥物緩釋冠脈支架（2012BAI18B02；2012-2015年）；項目研究骨干（排名第三）;

獎勵與榮譽：

2010年度重慶大學 優秀博士論文

2011年度重慶市 優秀博士論文

201年重慶大學黃尚廉院士創新獎教金獲得者

2014、2015、2016年度重慶大學優秀工作者

熱忱歡迎藥學，化學，生物學，力學，材料科學和醫學等相關學科、專業并對新藥、生物材料與生物醫學工程領域感興趣的本科生、碩士研究生報考研究生，也歡迎有類似背景的優秀本科生進實驗室學習。