北京大學藥學院化學生物學專業(yè)碩士研究生導師信息：葛澤梅

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葛澤梅：副教授，碩士生導師。

Tel: 010-82801504

E-mail: zmge@bjmu.edu.cn

通訊地址：北京市海淀區(qū)學院路38號藥學樓504室 郵編：100191

多年來一直從事有機化學、藥物化學、化學生物學的科研與教學工作。主要研究方向為基于作用機制的雜環(huán)類化合物的設(shè)計、合成、合成方法及生物活性研究。已主持完成國家自然科學基金2項，作為主要參加者完成國家自然科學基金3項以及“973”子課題等。目前主持或承擔國家“十一五”“北京大學綜合性創(chuàng)新藥物研究開發(fā)技術(shù)大平臺”的候選藥物研究品種及新藥臨床前研究課題。在國內(nèi)外學術(shù)刊物上發(fā)表論文40余篇，申請專利6項。

主要研究領(lǐng)域：

1. 基于作用機制的雜環(huán)類化合物的設(shè)計、合成、合成方法及生物活性研究

2. 氨基二硫代甲酸酯類化合物的設(shè)計、合成及抗腫瘤活性研究

3. 新型酪氨酸激酶抑制劑的設(shè)計、合成及活性研究

4. 硫醇替代試劑的應(yīng)用擴展與研究

代表性論文

1.Ri-Dong Li, Xin Zhang, Qiao-Yan Li, Ze-Mei Ge*, Run-Tao Li* ,Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. Bioorg. Med. Chem. Lett. 2011, 21, 3637–3640.

2.Wang, Junfeng; Qi, Chao; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Efficient direct asymmetric vinylogous Michael addition reactions of g -butenolides to chalcones catalyzed by vicinal primary-diamine salts Chem. Commun., 2010, 46, 2124–2126 .

3.Wang, Junfeng; Li, Qin; Qi, Chao; Liu, Yi; Ge, Zemei*; Li, Runtao*. Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines. Organic & Biomolecular Chemistry,  (2010),  8(19),  4240-4242.

4.Wang, Junfeng; Wang, Xin; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751–1753 .

5.MENG LEI, SHUAI XIA, JUNFENG WANG, ZEMEI GE,* TIEMING CHENG, AND RUNTAO LI*，An Efficient Dipeptide-Catalyzed Direct Asymmetric Aldol Reaction of Equimolar Reactants in Solid Media，CHIRALITY, 22:580–586 (2010).

6.Fang-bin Han,Ze-mei Ge,*Tie-ming Cheng,Run-tao Li* ,Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides, Synlett., 2009, 4, 648-650.

7.Zhong-qing Wang, Ze-mei Ge,* Tie-ming Cheng, Run-tao Li*, Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water, Synlett., 2009, 7, 2020-2022.

8.Jun-feng Wang, Meng Lei, Qin Li, Ze-mei Ge,* Xin Wang, Run-tao Li*, A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway, Tetrahedron.65(2009), 4826-4833

9.ZHU, Jirang(朱繼讓), LI, Ridong(李日東), GE, Zemei*(葛澤梅), CHENG, Tieming(程鐵明), LI, Runtao*(李潤濤),  Synthesis of β-Hydroxy Sulfides via Thiolysis of Epoxides Using S-Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium, Chinese Journal of Chemistry, 2009, 27, 791-796.

10.WANG, Zhongqing(王仲清), GE, Zemei*(葛澤梅), CHENG, Tieming(程鐵明), LI, Runtao*(李潤濤), An Efficient Four-Component, One-Pot Synthesis of  Poly-Substituted Pyrimidines in Water, Chinese Journal of Chemistry, 2009, 27, 834-838.

11.XuYan, Ze­Mei Ge*,Tie­Ming Cheng and Run­Tao Li*, One­pot synthesis of 1,3,4­oxadiazole­5­thioethers in water, Journal of Chinese Pharmaceutical Sciences 17 (2008 ) 277-280.

12.Song-wen Lin,a Qi Sun,a Run-tao Li,*a,b Tie-ming Cheng,a Ze-mei Ge*a, Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters. Synthesis, 2007, 13, 1933-1938.

13.Yan Zhao,a Ze-Mei Ge,*a Tie-Ming Cheng,a Run-Tao Li*a,b, Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water. Synlett.,  2007, 10, 1529-1532.

14.Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng and Ze-Mei Ge,* Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP), Bioorganic & Medicinal Chemistry Letters, 2006, 16, 3727-3730.

15.GE, Ze-Mei, LI, Qin, ZHENG, Shao-Jun, CHENG, Tie-Ming, CUI, Yu-Xin, LI, Run-Tao*, Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates, Chinese Journal of Chemistry, 2006, 24, 381-385.

16.Ze-mei Ge, Jia-ling Cui, Yan-ling Wang, Tie-ming Cheng, Run-tao Li*. A mild and efficient synthesis of 4, 5-disubstituted 3-amino-4-hydroxythiazolidine-2-thiones and S, N- disubstituted 1, 3, 4- thiadiazole-2-thiones. Synthesis, 2004, 8, 1257-1261.