西安交通大學研究生導師信息：馮智輝

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Personal information

Name : Zhi-hui Feng

Day of birth : Dec, 1983

E-mail: hugofzhe@gmail.com

zhfeng@mail.xjtu.edu.cn
 
Employment

2012 – Present

Center for Mitochondrial Biology and Medicine, Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, China

2009 – Present

Director’s Assistant, Institute of Mitochondrial Biology and Medicine, Xi’an Jiaotong University, China

Education

2006 –2011Ph.D Insititute for nutritional sciences, Shanghai insitutes for biological Sciences, Chinese Academy of Sciences, Shanghai, China

Superviser : Dr. Yan Chen ; Dr. Jiankang Liu

2008- 2011     Visiting student Institute of Mitochondrial Miology and Medicine, Xi’an Jiaotong University, Xi’an, China

2009 Visiting student Department of Urology, Chao Family Cancer Center, UC Irvine Medicial Center, USA

2001 - 2005 BS Marine College, Shandong University, Weihai, China. 

Activities

2011 Organizing committee, International Symposium of Mitochondrial Biology and Medicine & Chinese-Mit’2011.

2011 Organizing committee, Nestlé Research Center-Xi’an Jiaotong University Nutrition and Health Laboratory Opening Ceremony.

2008 - 2009 Establishment of Institute of Mitochondrial biology and Medicine (IMBM), Xi’an, China

Honors

2011 Outstanding student Nestlé prize, Nestlé Research Center and Xi’an Jiaotong University Joint Laboratory

2011 Oxygen Club of California Young Investigator Prize, International Symposium on Mitochondrial Biology and Medicine

2010 Excellent student awards, Institute of mitochondrial biology and medicine, Xi’an Jiaotong University

2004 Shandong University excellent student awards

2003 Shandong University excellent student awards

2001 Shandong University excellent student awards

Research experience

1. Mitochondrial targeting of nutrtional intervention on age related macular degeneration (AMD). Degeneration of retinal pigment epithelium (RPE) cell is considered major cause that induces AMD, while oxidative stress induced mitochondrial dysfunction is closely related RPE degeneration. Using ARPE-19 cell model, I have selected several nutritients that prevent oxidative stress induced RPE cell death by activating mitochondrial biogenesis, improving mitochondrial function and inducing phase II enzymes.
 
2. Mitochondrial dynamic regulation in obesity, diabetic development and effects of nutrional intervention. Mitochondrial dysfunction is associated with development of obesity and diabetes. I’m interested in finding out how mitochondrial dynamic including mitochondrial biogenesis, degradation, fusion, fission affect mitochondrial function during obesity and diabetic progression. Using several cell and animal models, I intent to find effective nutritients which could inhibit obesity, diabetes, and associated fatty liver development by regulating mitochondrial function.
 
3. Involvement of mitochondrial dysfunction in prenatal stress induced offspring congivitive decline and effects of nutritional intervention. It has been well indicated that prenatal stress could induce offspring cognitive decline. My study showed that prenatal stress induced mitochondrial dysfunction and oxidative damage in offspring hippocampus might be the major cause. Besides the well-know role in children brain development, I found novel role of docosahexaenoic acid (22 :6n-3 ; DHA) in protecting prenatal stress induced cognitive dysfuntion involving the modulation of mitochondrial functions and dynamics.
 
4. Autophagy and mitochondrial remodeling in long-term strenuous exercise. Physical exercise is considered to exert a positive effect on health. While, I found strenuous or excessive exercise causes fatigue and damage to muscle and immune functions thereby decrease endurance capacity. I’m interested in cross talking between autophay and mitochonrial dynamic during exercise.

Research Profile (http://www.researcherid.com/rid/E-7408-2011)

Publications (*corresponding author)

1. Xu J, Cao K, Li Y, Zou X, Chen C, Szeto IM, Dong Z, Zhao Y, Shi Y, Wang J, Liu J*, Feng Z*. Bitter Gourd Inhibits the Development of Obesity-Associated Fatty Liver in C57BL/6 Mice Fed a High-Fat Diet. Journal of Nutrition. 2014 Feb 12. [Epub ahead of print]

2. Zhao L, Zou X, Feng Z*, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F*, Liu J. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Experimental Gerontology. 2014 Feb 8. [Epub ahead of print]

3.  Liu J, Peng Y, Feng Z, Shi W, Qu L, Li Y, Liu J, Long J*. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radical Biology & Medicine. 2014 Jan [Epub ahead of print]

4. Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, Pang W, Zhao J, Zhao F, Li H, Zheng A, Sun W, Long J, Szeto IM, Zhao Y, Dong Z, Zhang P, Wang J, Lu W, Zhang Y, Liu J*, Feng Z*. Mitochondrial dysfunction in obesity associated non-alcoholic fatty liver disease: The protective effects of pomegranate with its active component punicalagin. Antioxidants & Redox Signaling; 2014. [Epub ahead of print]

5. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y, Long J, Liu J*, Feng Z*. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radical Biology & Medicine; 67:396-407; 2014

6. Li Y, Zou X, Cao K, Xu J, Yue T, Dai F, Zhou B, Lu W, Feng Z*, Liu J. Curcumin analogue 1, 5-Bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibit enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. Toxicology and Applied Pharmacology; 272:726-735; 2013.

7. Zheng A, Li H, Wang X, Feng Z, Xu J, Cao K, Zhou B, Wu J, Liu J*. Anticancer Effect of a Curcumin Derivative B63: ROS Production and Mitochondrial Dysfunction. Curr Cancer Drug Targets; 2013. [Epub ahead of print]
8. Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Li Y, Wang Y, Wurtz K, Weber P, Long J*, Liu J*. Hydroxytyrosol Promotes Superoxide Production and Defects in Autophagy Leading to Anti-proliferation and Apoptosis on Human Prostate Cancer Cells. Current Cancer Drug Targets 13:625-639; 2013.

9. Luo C, Li Y, Zhou B, Yang L, Li H, Feng Z, Li Y, Long J*, Liu J*. A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis 2013.

10. Luo C, Li Y, Yang L, Feng Z, Li Y, Long J*, Liu J*. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology 14:503-511; 2013.

11. Luo C, Li Y, Wang H, Feng Z, Li Y, Long J, Liu J*. Mitochondrial accumulation under oxidative stress is due to defects in autophagy. Journal of Cellular Biochemistry 114:212-219; 2013.

12. Qu X, Shen L, Zheng Y, Cui Y, Feng Z, Liu F*, Liu J*. A Signal Transduction Pathway from TGF-beta1 to SKP2 via Akt1 and c-Myc and its Correlation with Progression in Human Melanoma. The Journal of Investigative Dermatology 134:159-167; 2014.

13. Feng Z, Zou X, Jia H, Li X, Zhu Z, Liu X, Bucheli P, Ballevre O, Hou Y, Zhang W, Wang J, Chen Y, Liu J*. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. Antioxidants & Redox Signaling 16:275-289；2012. 14. Feng Z, Bai L, Yan J, Li Y, Shen W, Wang Y, Wertz K, Weber P, Zhang Y, Chen Y, Liu J*. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol. Free Radical Biology & Medicine 50:1437-1446; 2011.

15. Feng Z, Jia H, Li X, Bai Z, Liu Z, Sun L, Zhu Z, Bucheli P, Ballèvre O, Wang J, Liu J*. A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro. Neurochemical Research 35:702-711; 2010.

16. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J*. alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. The Journal of Nutritional Biochemistry 21:1222-1231; 2010.

17. Yan Ja, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J, Liu J*. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. The Journal of Nutritional Biochemistry 23:716-724; 2012. (aEqual contributor)

18. Zou X, Feng Z, Li Y, Wang Y, Wertz K, Weber P, Fu Y, Liu J*. Prevention of oxidative stress-induced cell apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: Activation of Nrf2, JNK and p62/SQSTM1 pathways. The Journal of Nutritional Biochemistry. 2012;23:994-1006

19. Shen, W.; Hao, J.; Feng, Z.; Tian, C.; Chen, W.; Packer, L.; Shi, X.; Zang, W.; Liu, J. Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Brtish Journal of Pharmacology 162:1213-1224; 2011.

20. Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi X, Liu J*. Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. The Journal of Nutritional Biochemistry 21:1089-1098; 2010.

21. Jia H, Liu Z, Li X, Feng Z, Hao J, Li X, Shen W, Zhang H, Liu J*. Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model. Neurobiology of Aging 31:636-646; 2010.

22. Hao J, Shen W, Yu G, Jia H, Li X, Feng Z, Wang Y, Weber P, Wertz K, Sharman E, Liu J*. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. The Journal of Nutritional Biochemistry 21:634-644; 2010.

23. Jia H, Li X, Gao H, Feng Z, Li X, Zhao L, Jia X, Zhang H, Liu J*. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease. Journal of Neuroscience Research 86:2083-2090; 2008.

24. Cai X, Jia H, Liu Z, Hou B, Luo C, Feng Z, Li W, Liu J*. Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease. Journal of Neuroscience Research 86:3622-3634; 2008.