中國藥科大學(xué)生命科學(xué)與技術(shù)學(xué)院導(dǎo)師信息介紹：姚文兵

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姚文兵 教授，男，博士生導(dǎo)師,中國藥科大學(xué)副校長

主要經(jīng)歷

1962年6月生，1983年畢業(yè)于中國藥科大學(xué)生物制藥專業(yè)，后獲碩士、博士學(xué)位。1990年研究生畢業(yè)后留校任教。

自留校任教以來，一直從事教學(xué)、科研和管理工作。現(xiàn)任中國藥科大學(xué)微生物與生化藥學(xué)教授（博士生導(dǎo)師）、中國藥科大學(xué)副校長。兼任國家食品藥品監(jiān)督管理局 藥品、保健食品評審委員，國家發(fā)改委藥品價(jià)格決策專家委員會(huì)委員，中國生物化學(xué)與分子生物學(xué)會(huì)工業(yè)化專業(yè)委員會(huì)委員，教育部高職高專藥品類專業(yè)教學(xué)指導(dǎo)委 員會(huì)主任委員，教育部高等學(xué)校藥學(xué)專業(yè)教學(xué)指導(dǎo)分委員會(huì)秘書長，全國高等醫(yī)學(xué)教育學(xué)會(huì)副秘書長，全國高等醫(yī)學(xué)教育學(xué)會(huì)藥學(xué)教育研究會(huì)副理事長兼秘書長， 《藥物生物技術(shù)》副主編，《藥學(xué)教育》常務(wù)副主編，《中國藥學(xué)年鑒》、《中國藥科大學(xué)學(xué)報(bào)》等雜志編委。

主要科研工作簡介

主要從事的研究領(lǐng)域

多肽、蛋白質(zhì)類藥物的分子改構(gòu)（包括基于基因密碼子擴(kuò)展的分子改構(gòu)）和定點(diǎn)修飾研究以及生物新藥的研制。

課題資助情況

在以上研究領(lǐng)域已主持完成了國家科技重大專項(xiàng)課題、國家863項(xiàng)目、國家自然科學(xué)基金項(xiàng)目、教育部重點(diǎn)項(xiàng)目、江蘇省重點(diǎn)項(xiàng)目等國家及省部級課題26項(xiàng)。目前正主持國家自然科學(xué)基金、國家科技重大專項(xiàng)課題、博士點(diǎn)基金、江蘇省科技創(chuàng)新與成果轉(zhuǎn)化專項(xiàng)等項(xiàng)目7項(xiàng)。

完成的主要科研工作及獲獎(jiǎng)情況

長期從事多肽、蛋白質(zhì)類藥物的分子改構(gòu)（包括基于基因密碼子擴(kuò)展的分子改構(gòu)）和定點(diǎn)修飾研究以及生物新藥的研制，圍繞多肽和蛋白質(zhì)藥物的分子改構(gòu)及其在創(chuàng)新藥物中應(yīng)用開展系列研究，1）建立了與國際前沿同步的非天然氨基酸定點(diǎn)改構(gòu)技術(shù)體系； 2) 建立了多肽、蛋白質(zhì)類藥物修飾技術(shù)平臺(tái)和質(zhì)量評價(jià)體系， 3）開展長效多肽、蛋白質(zhì)類創(chuàng)新藥物研究，完成了PEG—ED、PEG2—IFNcon 等長效蛋白質(zhì)類藥物和長效多肽類藥物的臨床前研究。在該領(lǐng)域主持國家“重大新藥創(chuàng)制”科技重大專項(xiàng)、國家“863”項(xiàng)目、國家自然科學(xué)基金等國家級及省部級課題26項(xiàng)；帶領(lǐng)的科研團(tuán)隊(duì)獲得江蘇省“青藍(lán)工程”科技創(chuàng)新團(tuán)隊(duì)。近五年，獲授權(quán)發(fā)明專利10項(xiàng)，發(fā)表科研論文72篇， SCI論文37篇，出版著作5部。

榮獲國家級教學(xué)名師，入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”，江蘇省“333高層次人才培養(yǎng)工程”第二層次培養(yǎng)對象，江蘇省“六大人才高峰”，獲全國高校優(yōu)秀青年教師獎(jiǎng)（教育部霍英東教育基金會(huì)），江蘇省優(yōu)秀教育工作者等榮譽(yù)稱號。為國家優(yōu)秀教學(xué)團(tuán)隊(duì)帶頭人，國家精品課程《藥學(xué)生物化學(xué)基礎(chǔ)》課程負(fù)責(zé)人，獲國家級教學(xué)成果獎(jiǎng)一等獎(jiǎng)3項(xiàng)、國家級教學(xué)成果獎(jiǎng)二等獎(jiǎng)1項(xiàng)，獲江蘇省教學(xué)成果獎(jiǎng)特等獎(jiǎng)2項(xiàng)、江蘇省教學(xué)成果獎(jiǎng)一等獎(jiǎng)2項(xiàng)。獲江蘇省科技進(jìn)步三等獎(jiǎng)2項(xiàng)。

研究生培養(yǎng)情況

已培養(yǎng)碩士研究生62名，博士研究生20名。

近期發(fā)表的代表性論文

1．Mingming Gao,Yue Tong,Hong Tian,Xiangdong GaoandWenbing Yao. Recombinant production of mGLP-1 by coupling of refolding and intein-mediated self-cleavage (CRIS). Appl Microbiol Biotechnol. DOI 10.1007/s00253-012-4163-4

2．Mingming Gao,Yuhao Jin,Yue Tong, Hong Tian,Xiangdong Gao,Wenbing Yao. A site-specific PEGylated analog of exendin-4 with improved pharmacokinetics and pharmacodynamics in vivo. Journal of Pharmacy and Pharmacology. doi: 10.1111/j.2042-7158.2012.01545.x

3．Hong Tian, Yuan Guo, Xiangdong Gao,Wenbing Yao. PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. Journal of Pharmacy and Pharmacology. DOI:10.1111/j.2042-7158.2012.01575.x

4．Wei Guo, Chen Luo, Chen Wang, Yue Zhu, Xin Wang, Xiangdong Gao, Wenbing Yao. Protection against Th17 Cells Differentiation by an Interleukin-23 Receptor Cytokine-Binding Homology Region. Plos One. 2012, 7(9): e45625

5．Mingming Gao , Yue Tong , Wen Li , Xiangdong Gao , Wenbing Yao. Improving the anti-diabetic activity of GLP-1 by fusion with globular adiponectin. Artificial Cells, Blood Substitutes, and Biotechnology. DOI: 10.3109/10731199.2012. 712042

6．Hai Chen, Yingfei Lu, Zhengzhi Fang, Jingxian Liu, Hong Tian, Xiangdong Gao and Wenbing Yao. High-level production of uricase containing keto functional groups for site-specific PEGylation. Biochemical Engineering Journal, 2011,58(59): 25-32

7．Zhengzhi Fang, Yaguang Liu, Jingxian Liu, Renhua Sun, Hai Chen, Xiangdong Gao, Wenbing Yao. Designing and engineering of a site-specific incorporation of a keto group in uricase. Chemical Biology & Drug Design, 2011, 78(3):353-360

8．Yuge Niu, Zhuohong Xie, JunJie Hao, WenBing Yao, Jin Yue, Liangli (Lucy) Yu. Preparation of succinylated derivatives of psyllium and their physicochemical and bile acid-binding properties. Food Chemistry, 2012,132: 1025–1032

9．Cao Jin, Meng Fang, Gao Xiangdong, Dong Hongxia, Yao Wenbing. Expression and Purification of a Natural N-Terminal Pre-ligand Assembly Domain of Tumor Necrosis Factor Receptor 1 (TNFR1 PLAD) and Preliminary Activity Determination. The Protein Journal, 2011, 30(4): 281-289

10． Yuge Niu, Hengyu Wang, Zhuohong Xie, Monica Whent, Xiangdong Gao, Xian Zhang, Shan Zou, Wenbing Yao, Liangli Yu. Structural Analysis and Bioactivity of a Polysaccharide from the Roots of Astragalus membranaceus (Fisch) Bge. var. mongolicus (Bge.) Hsiao. Food Chemistry, 2011, 128: 620–626

11． Jingjing Sun, Xiaoda Song, Hong Tian, Yuhao Jin, Xiangdong Gao, Wenbing Yao. Synthesis of a novel Histidine-Targeting poly(ethylene glycol) and modification of lysozyme. Journal of Applied Polymer Science, 2011, 119(4): 2183-2188

12． Ma Chen, Gao Mingming, Liu Wenchao, Zhu Jing, Tian Hong, Gao Xiangdong, Yao Wenbing. Intein-mediated Expression and Purification of an Analog of Glucagon-like Peptide-1 in Escherichia coli. Protein and Peptide Letters, 2010,17(10): 1245-1250

13． Mingming Gao, Chen Ma, Wenchao Liu, Jing Zhu, Hong Tian, Xiangdong Gao, Wenbing Yao. Production and purification of an analog of glucagon-like peptide-1 by auto-induction and on-column cleavage in Escherichia coli. World J Microbiol Biotechnol, 2010, 26(9): 1675–1682

14． Min Ren, Wei Yan, Wenbing Yao, Lei Jin, Xiangdong Gao. Enzymatic degradation  products from a marine polysaccharide YCP with different immunological activity and binding affinity to macrophages, hydrolyzed by a-amylases from different origins. Biochimie, 2010,92:411-417

15． Wei Liu, Jing Xu, Pu Jing, Wenbing Yao, Xiangdong Gao, Liangli (Lucy) Yu. Preparation of a hydroxypropyl Ganoderma lucidum polysaccharide and its physicochemical properties. Food Chemistry, 2010, 122: 965–971

16． WeiLiu, HengyuWang, WenbingYao, XiangdongGao and Liangli (Lucy)Yu. Effects of Sulfation on the Physicochemical
and Functional Properties of a Water-Insoluble Polysaccharide Preparation from Ganoderma lucidum. J. Agric. Food Chem., 2010, 58 (6): 3336–3341

17． WeiLiu, ZhuohongXie, BoceZhang, QinWang, WenbingYao, XiangdongGao and Liangli (Lucy)Yu. Effects of Hydroxypropylation on the Functional Properties of Psyllium.J. Agric. Food Chem., 2010, 58 (3): 1615–1621

18． WeiLiu, BoceZhang, QinWang, ZhouhongXie, WenbingYao, XiangdongGao and Liangli (Lucy)Yu. Effects of Sulfation on the Physicochemical and Functional Properties of Psyllium. J. Agric. Food Chem., 2010, 58 (1): 172–179

19． Wei Liu, Hengyu Wang, Xiubing Pang, Wenbing Yao, Xiangdong Gao. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. International Journal of Biological Macromolecules,2010,46:451-457

20． Yue Tong, Kai Zhong, Hong Tian, Xiangdong Gao, Xiangyang Xu, Xiaojin Yin, Wenbing Yao. Characterization of a monoPEG20000-Endostar. International Journal of Biological Macromolecules,2010,46(3):331-336

21． MingmingGao, HongTian, ChenMa, XiangdongGao, WeiGuo and WenbingYao. Expression, Purification, and C-terminal Site-Specific PEGylation of Cysteine-Mutated Glucagon-Like Peptide-1. Applied Biochemistry and Biotechnology, 2010,162(1):155-165

22． Shan Zou, Xian Zhang, Wenbing Yao, Yuge Niu, Xiangdong Gao. Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L. Carbohydrate Polymers, 2010,80:1161-1167

23． Renhua Sun, Heng Zheng, Zhengzhi Fang and Wenbing Yao. Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-l-phenylalanine. Biochemical and Biophysical Research Communications, 2010, 391(1): 709-715

24． Jin Cao‌, Yu Du‌, Hong Tian‌, Xiangdong Gao‌, Wenbing Yao‌. Quantitative determination of pegylated consensus interferon in rhesus monkey serum using a competitive enzyme-linked immunosorbent assay. Immunopharmacol Immunotoxicol, 2009,31(4):543-549