中國水產科學研究院長江水產研究所導師信息介紹：李志華

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個人簡歷

姓名：李志華

性別：男

民族：漢

出生日期：1979年6月

籍貫：河北省辛集市

工作單位：中國水產科學研究院長江水產研究所     研究員

通信地址：湖北省武漢市東湖新技術開發區武大園一路8號，430223

電子郵件: lzhyfi@126.com; zhihuali06@yahoo.com

現為長江水產研究所水生態毒理學科負責人。博士畢業于捷克南波希米亞大學，長期從事水生態毒理學研究。2010年赴美國加州大學河濱分校Prof. DanelSchlenk實驗室訪問交流，主要是對水體中污染物對小型魚類的神經行為學影響進行研究。2011年-2012年期間，在新加坡國立大學從事博后研究，主要研究方向是利用斑馬魚做為模式生物進行毒理基因組學影響。

到2014年為止，以第一作者發表34 篇（總共發表47篇），最高影響因子8.633，文章總被引超過521次（他引382次），最高單篇被引用為44次，H-index=14。目前擔任SCI刊物Bulletin of Environmental Contamination and Toxicology（IF=1.316）的編委和BioMed Research International（IF=2.880）專刊的客座編輯，并擔任PLoS ONE, AquaticToxicology等22種該領域SCI期刊的獨立審稿人。現為科技部國際合作專項評審專家庫成員，中國環境科學學會理事會員，中國毒理學會環境與生態毒理專業委員會會員和中國化學學會會員。

國外留學期間獲得獎勵包括：南波西米亞大學漁業與水保護學院35歲以下青年優秀科研成果一等獎（2009）；國家優秀自費留學生獎學金（2010）；南波西米亞大學優秀科技成果校長獎（2011）。

研究興趣：

目前主要是利用各種生物標志物對水環境中的污染物進行生態健康評價，工作主要從兩方便展開，一是將水環境中典型污染物的生態毒性效應及分子機制研究，主要以淡水魚類作為活體模型，將微觀與宏觀相結合，從分子/生化/生理/個體層次上進行，并建立之間的聯系，探索污染物對水生生物的生殖毒性、神經毒性、發育毒性、健康危害，以及多種污染物在環境條件下的復合作用，通過轉錄組、蛋白質組學分析來表征污染物的制毒作用機制，從而為污染物的危險評價以及為我國可持續發展戰略、生態安全及環境保護決策提供理論依據；二是針對新興污染物（如藥物殘留活性物質、人工納米污染物等）的分子標記物的篩選及其環境健康風險評估，主要以小型淡水魚類（如斑馬魚、青鳉等）為動物模型，從轉錄組學和蛋白質組學角度研究動物有關基因在不同環境脅迫下的表達與調控、以及蛋白質譜的變化，在分子水平尋找人類及動物典型污染物暴露的更敏感、有效的生物標記物，發展環境污染的早期預警系統，并通過比較生物學，找出該污染物在其他哺乳動物和人類的保守基因或信號通路，以便對污染物的環境健康風險評估提供科學依據。

近期主持課題情況：

2010，殘留藥物維拉帕米長期暴露對虹鱒蛋白組學及抗氧化反應的影響 (南波西米亞大學課題，007/2010/Z)

2012-2014， -利用被動采樣/質譜技術對長江愛那個流域新型污染物的檢測及鑒定 (中捷政府間科技合作項目，LH12179)

2013-2015，氣體過飽和、重金屬和典型有機污染物對魚類等水生生物影響機理研究（三峽總公司課題-重金屬部分，07011034）

2013-2014，三峽庫區水體中典型環境激素有機錫化合物的生態毒理學研究（農業部留學人員科技活動擇優資助項目）

2014-2016，環境激素三丁基錫對鯉魚的危害及其機制（中國水產科學研究院基本科研業務費，2014A02YQ01）

2015-2016，不同溫度下草魚幼魚對汞脅迫的耐受性研究（湖北省自然基金，2014CFB266）

2015-2017，溫度對草魚幼魚在低劑量汞脅迫下毒代動力學及生理應答影響研究（國家自然科學基金，21407181）

近五年獲獎情況：

2009，南波西米亞大學漁業與水保護學院35歲以下青年優秀科研成果一等獎；

2010，國家優秀自費留學生獎學金；

2011，南波西米亞大學優秀科技成果校長獎。

學術兼職

SCI刊物編輯：Bulletin of Environmental Contamination and Toxicology

SCI刊物特約編輯：BioMed Research International專刊“Fish and Crayfish Toxicology”和“Endocrine Toxicology in Aquatic System”

SCI刊物獨立審稿人：PLoS ONE, Water Research, Journal of Hazardous Materials, Chemosphere, BMC Veterinary Research, Science of the Total Environment, Comparative Biochemistry and Physiology-Part B, Part C, Environmental Toxicology and Chemistry, Mutation Research, Ecotoxicology and Environmental Safety, Environmental Toxicology, Experimental and Molecular Pathology, Marine Environmental Research, Aquaculture Nutrition, Food and Chemical Toxicology, Diseases of Aquatic Organisms, Journal of Environmental Management, Fish Physiology and Biochemistry, Bulletin of Environmental Contamination and Toxicology, Aquaculture research, Reproductive Biology, Acta veterinaria Brno.

中國環境科學學會理事會員，中國毒理學會環境與生態毒理專業委員會會員和中國化學學會會員。

河北大學、華中農業大學、上海海洋大學碩士研究生導師。

近五年以第一作者發表SCI文章列表

2014之后：

Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F.,& Ni Z.H. 2014. Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 161, 53-57.

Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F.,& Ni Z.H. 2014.  Effects of mercury on oxidative stress and gene expression of potential biomarkers in larvae of the Chinese rare minnow Gobiocypris Rarus. Archives of Environmental Contamination and Toxicology, 67, 245-251.

Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F.,& Ni Z.H. 2014. Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride. Environmental Toxicology and Pharmacology, 38, 325-331.

Li Z.H*., Li P.,& Shi Z.C. 2014. Molecular responses in digestive tract of juvenile common carp after chronic exposure to sublethal tributyltin. Ecotoxicology and Environmental Safety, 109, 10-14.

Li, Z.H*., Li, P., Chen, L., 2014. Temperature affects Hg-induced antioxidant responses in Chinese rare minnow Gobiocypris rarus larvae in vitro. Bulletin of Environmental Contamination and Toxicology,93, 666-669.

Li, Z.H*., Li, P. 2015. Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress. Chemico-Biological Interactions, 227, 32–36

Li Z.H*., Li P.,& Shi Z.C. 2015.Responses of the hepatic glutathione antioxidant defense system and related gene expression in juvenile common carp after chronic treatment with tributyltin. Ecotoxicology, 24, 700-705.

Li Z.H*., Li P.,& Shi Z.C. 2014.Chronic effects of tributyltin on multiple biomarkers responses in juvenile common carp, Cyprinus carpio. Environmental Toxicology. accepted.

Li Z.H*., Li P.,& Shi Z.C. 2014.Alterationof antioxidant response and expression of related genes by Cadmium in Chinese rare minnow larvae. CLEAN - Soil, Air, Water. accepted.

Li Z.H*., Li P.,& Shi Z.C. 2014.Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin. Environmental Toxicology. accepted.

Li Z.H*., Li P.,& Shi Z.C. 2015.Chronic exposure to tributyltin induces brain functional damage in juvenile common carp (Cyprinus carpio) PLoS ONE. accepted.

2014年之前:

Li, Z.H., Xu, H.Y., Zheng, W.L., Lam, S.H., Gong, Z.Y*. 2013. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. PLoS ONE, 8(10): e77292.

Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T. 2013. Multiple biomarkers responses in juvenile rainbow trout, Oncorhynchus mykiss, after acute exposure to a fungicide propiconazole. Environmental Toxicology 28(3):119-126.

Li, Z.H*., Li, P., Sulc, M., Hulak, M., Randak, T., 2012. Hepatic proteome sensitivity in rainbow trout after chronically exposed to a human pharmaceutical Verapamil. Molecular and Cellular Proteomics, 11(1): M111.008409.

Li, Z.H*., Zlabek, V., Turek, J., Velisek, J., Pulkrabova, J., Kolarova, J., Sudova, E., Berankova, P., Hradkova, P., Hajslova, J., Randak, T., 2011. Evaluating environmental impact of STPs situated on streams in the Czech Republic: An integrated approach to biomonitoring the aquatic environment. Water Research 45 (3): 1403-1413.

Li, Z.H*., Velisek, J., Zlabek, V., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T., 2011. Chronic toxicity of Verapamil on juvenile rainbow trout (Oncorhynchus mykiss): effects on morphological indices; hematological parameters and antioxidant responses. Journal of Hazardous Materials 185 (2-3): 870-880.

Li Z.H*., Velisek J., Grabic R., Li P., Kolarova J., Randak T. 2011. Use of hematological and plasma biochemical parameters to assess the chronic effects of a fungicide Propiconazole on a freshwater teleost. Chemosphere, 83(4): 572-578.

Li, Z.H*., Li, P., Randak, T. 2011. Evaluating the toxicity of environmental concentrations of waterborne chromium (VI) to a model teleost, Oncorhynchus mykiss: a comparative study of in vivo and in vitro. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 153(4): 402-407.

Li, Z.H*., Zlabek, V., Li, P., Grabic, R., Velisek, J., Machova, J., Randak, T., 2011. Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD. Ecotoxicology and Environmental Safety 74 (3): 319-327.

Li Z.H*., Li P., Randak T. 2011.Protective roles of calcium channel blocker against cadmium-induced physiological stress in freshwater teleost Oncorhynchus mykiss.  Water, Air, & Soil Pollution 220 (1-4):293-299.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Randak, T., 2011. Biochemical responses in gill of rainbow trout exposed to propiconazole. Central European Journal of Biology 6 (1): 84-90.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T., 2011. Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole. Czech Journal of Animal Science 56(2):64-72.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Machova, J., Velisek, J., Randak, T., 2010. Effects of exposure to sublethal propiconazole on the antioxidant defense system and Na+-K+-ATPase activity in brain of rainbow trout, Oncorhynchus mykiss. Aquatic Toxicology 98(3): 297-303.

Li, Z.H*., Li, P, Rodina, M, Randak, T., 2010. Evaluating the function of calcium antagonist on the cadmium-induced stress in sperm of Russian sturgeon, Acipenser gueldenstaedtii. Aquatic Toxicology 100(4): 373-375.

Li, Z.H*., Li, P, Rodina, M, Randak, T., 2010. Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa. Chemosphere 80(5): 530-534.

Li, Z.H*., Velisek, J., Zlabek, V., Grabic, R., Machova, J., Randak, T., 2010. Enzymatic alterations and RNA/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine. Ecotoxicology 19(5): 872–878.

Li, Z.H*., Velisek, J., Zlabek, V., Grabic, R., Machova, J., Kolarova, J.,  Randak, T., 2010. Hepatic antioxidant status and haematological parameters in rainbow trout, Oncorhynchus mykiss, after chronic exposure to carbamazepine.  Chemico-Biological Interactions 183(1): 98-104.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Machova, J., Velisek, J., Randak, T., 2010. Effects of exposure to sublethal propiconazole on intestine-related biochemical responses in rainbow trout, Oncorhynchus mykiss. Chemico-Biological Interactions 185(3): 241-246.

Li, Z.H*., Li, P., Dzyuba, B., Randak, T., 2010. Influence of environmental related concentrations of heavy metals on motility parameters and antioxidant responses in sturgeon sperm. Chemico-Biological Interactions 188(3): 473-477.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2010. Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 151(1): 137-141.

Li, Z.H*., Li, P., Randak, T., 2010. Ecotoxocological effects of short-term exposure to a human pharmaceutical Verapamil in juvenile rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 152(3): 385-391.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Randak, T., 2010. Modulation of glutathione-related antioxidant defense system of fish, chronically treated by the fungicide propiconazole. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 152(3): 392-398.

Li, Z.H*., Zlabek, V., Li, P., Grabic, R., Velisek, J., Machova, J., Randak, T., 2010. Biochemical and physiological responses in liver and muscle of rainbow trout after long-term exposure to propiconazole. Ecotoxicology and Environmental Safety 73(6): 1391-1396.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2010. Physiological condition status and muscle-based biochemical responses in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine. Journal of Applied Toxicology 30(3): 197-203.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2009. Responses of antioxidant status and Na+-K+-ATPase activity in gill of rainbow trout, Oncorhynchus mykiss, chronically treated with carbamazepine. Chemosphere 77(11):1476-1481.

Li, Z.H*., Li, P., Randak, T., 2009. Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: An efficient approach to biomonitoring. Journal of Applied Toxicology 30(7): 644-648.

Li, Z.H*., Xie, S., Wang, J.X., Sales, J., Li, P., Chen, D.Q., 2009. Effect of intermittent starvation on growth and some antioxidant indexes of Macrobrachium nipponense (De Haan). Aquaculture research 40(5): 526-532.

Li, Z.H*., Randak, T., 2009. Residual pharmaceutically active compounds (PhACs) in aquatic environment: status, toxicity and kinetics. Veterinarni Medicina 52 (7): 295-314.

Li, P.*, Li, Z.H.*, Hulak, M., Rodina, M., Linhart, O., 2012. Regulation of spermatozoa motility in response to cations in Russian sturgeon (Acipenser gueldenstaedtii). Theriogenology 78(1):102-109 (IF = 2.521) (* corresponding author)