蘭州大學生命科學學院導師介紹：黎家

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學習經歷

1995 美國弗吉尼亞理工大學 博士 (Ph.D. Virginia Tech, 1995)
1989 中國科學院植物研究所 碩士 (M.S. Institute of Botany, CAS, 1989)
1984 蘭州大學生物系 學士 (B.S. Lanzhou University, 1984 )

工作經歷

1984-1986年在湖南師范大學生物系任助教。1990-1991年在中科院植物研究所任助研。1997-2002年在美國密蘇里大學哥倫比亞分校從事博士后研究。2002年8月起在美國俄克拉荷馬大學植物與微生物系任助理教授，2008年5月晉升為副教授，獲終身教職（tenured）。通過全球競聘獲任蘭州大學生命科學學院院長，于2009年3月全職回國工作。是國家"****"特聘專家，教育部“長江學者”特聘教授。獲2013-2014年度美國弗吉尼亞理工大學農學與生命科學學院杰出校友獎。

教學及指導研究生情況

給研究生講授“Plant Hormones”; 目前指導3名博士后，16名博士研究生、16名碩士研究生。

發表論文及專著

Selected Publications:

Guo, X., Qin, Q., Yan, J., Niu, Y., Huang, B., Guan, L., Li, Y., Ren, D.,Li, J., Hou, S. (2015) TYPE-ONE PROTEIN PHOSPHATASE 4 regulates pavement cell interdigitation by modulating PIN-FORMED 1 polarity and trafficking in Arabidopsis. Plant Physiology 167 (3), 1058-1075.

Qin, Q., Wang, W., Guo, X., Yue, J., Huang, Y., Xu, X., Li, J., Hou, S. (2014) Arabidopsis DELLA Protein Degradation Is Controlled by a Type-One Protein Phosphatase, TOPP4. PLoS Genet 10(7):e1004464. doi: 10.1371/journal.pgen.1004464.

Yang, Z.R., Zhang, C.J., Yang, X.J., Kun, L.,Wu, Z.X., Zhang, X.Y., Zheng, W.,Xun, Q.Q., Liu, C.L., Lu, L.L., Yang, Z.E., Qian, Y.Y., Xu, Z.Z.,Li, C.F., Li,J.*, Li, F.G.* (2014) PAG1, a cotton brassinosteroid catabolism gene, modulates fiber elongation. New Phytologist 203, 437-448. (* co-corresponding authors)

Qin, Z.X., Zhang, X.R., Zhang, X., Xin, W., Li, J., Hu, Y.X. (2014) The Arabidopsis transcription factor IIB-related protein BRP4is involved in the regulation of mitotic cell-cycle progression during male gametogenesis. Journal of Experimental Botany 65(9),2521-2531.

He, K., Xu, S., Li, J. (2013) BAK1 Directly Regulates Brassinosteroid Perception and BRI1 Activation. Journal of Integrative Plant Biology 55(12),1264-1270.

Li, J., Tax, F.E. (2013) Receptor-Like Kinases: Key Regulators of Plant Development and Defense. Journal of Integrative Plant Biology 55(12),1184-1187.

Ma, T. et al. (2013) Genomic insights into salt adaptation in a desert poplar. Nature Communications 4, 2797.

Qian, P., Han, B., Forestier, E., Hu, Z., Gao, N., Lu, W., Schaller, H., Li, J., Hou, S. (2013) Sterols are required for cell fate commitment and maintenance of the stomatal lineage in Arabidopsis. The Plant Journal 74, 1029-1044.

Zhao, B. and Li, J. (2012) Regulation of Brassinosteroid Biosynthesis and Inactivation. Journal of Integrative Plant Biology 54 (10), 746-759.

Wen, J., Li, J., and Walker, J.C. (2012) Overexpression of a Serine Carboxypeptidase Increases Carpel Number and Seed Production in Arabidopsis thaliana. Food and Energy Security 1(1), 61-69.

Du, J., Yin, H., Zhang, S., Wei, Z., Zhao, B., Zhang, J., Gou, X., Lin, H.*, and Li, J. (2012) Somatice Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana. Journal of Integrative Plant Biology54(6), 388-399.

Gou, X. and Li, J. (2012) Activation tagging. Methods in Molecular Biology 876, 117-133.

Gou, X., Yin, H., He, K., Du, J., Yi, J., Xu, S., Lin, H., Clouse, S.D., Li, J. (2012) Genetic Evidence for an Indispensable Role of Somatic Embryogenesis Receptor Kinases in Brassinosteroid Signaling. PLoS Genet 8(1): e1002452. doi:10.1371/journal.pgen.1002452

Li, J., Du, J., He, K., and Gou, X. (2012) Cell Death Control by Receptor Kinases in Arabidopsis thaliana. In, F.E. Tax and B. Kemmerling (editors) RECEPTOR-LIKE KINASES IN PLANTS: From Development to Defense. Springer. Volume 13, pp79-91.

Wei, Z-Y and Li, J. (2011) Receptor kinases mediated brassinosteroid signal transduction in plants. Chinese Bulletin of Life Sciences. 23 (11), 1106-1113.

An, J., Guo, Z., Gou, X., Li, J. (2011) TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana. Plant Signaling & Behavior, 6: 1117-1118.

Li, J.（2010） Multi-tasking of somatic embryogenesis receptor-like protein kinases. Curr Opin Plant Biol ,13: 509-514

Guo, Z., Fujioka, S., Blancaflor, E.B., Miao, S., Gou, X., and Li, J. (2010) TCP1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell 22, 1161-1173.

Yang, H., Gou, X., He, K., Xi, D., Du, J., Lin, H., Li, J. (2010) Arabidopsis BAK1 and BKK1 confer reduced susceptibility to Turnip Crinkle Virus. European Journal of Plant Pathology, 127: 147-156.

Gou, X., He, K., Yang, H., Yuan, T., Lin, H., Clouse, S.D., Li, J. (2010) Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11(1):19

Li, D., Wang, M., Xu Y.Y., Luo, W., Liu, Z.H., Li, J., Chong, K.(2009) Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield. Plant Biotechnol Journal 7(8): 791-806.

Wang, X., Kota, U., He, K., Blackburn, K., Li, J., Goshe, M.B., Huber, S.C., and Clouse, S.D.(2008) Sequential transphosphorylation of the BRI1/BAK1 receptor kinase pair impacts early events in brassinosteroid signaling. Developmental Cell 15, 220-235.

He, K., Gou, X., Powell, R.A., Yang, H., Yuan, T, Guo, Z., and Li, J. (2008) Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaling & Behavior 3 (10), 813-815.

Clouse, S.D., Goshe, M.B., Huber, S.C. and Li, J. (2008) Functional Analysis and Phosphorylation Site Mapping of Leucine-Rich Repeat Receptor-Like Kinases. In, GK Agrawal and R Rakwal (eds) Plant Proteomics: Technologies, Strategies and Applications. John Wiley & Sons, pp 469-484.

Heese, A., Hann, D.R., Gimenez-ibanex, S., Jones, A., He, K., Li, J., Schroeder, J.I., Peck, S.C., Rathjen, J.P. (2007) The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proc. Natl. Acad. Sci. USA 104, 12217-12222.

He, K., Gou, X., Yuan, T., Lin, H., Asami, T., Yoshida, S., Russell, S.D., Li, J. (2007) BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell death pathways. Current Biology 17, 1109-1115.

Yuan, T., Fujioka, S., Takatsuto, S., Matsumoto, S., Gou, X.,He, K., Russell, S.D., and Li, J. (2007) BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. The Plant Journal 51 (2), 220–233.

Li, J. and Gou, X. (2007) Brassinosteroids. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0020092]

Wang, L., Xu, Y.Y., Li, J., Powell, R.A., Xu, Z.H., and Chong, K. (2007) Transgenic rice plants ectopically expressing AtBAK1 are semi-dwarfed and hypersensitive to 24-epibrassinolide. Journal of Plant Physiology 164(5), 655-664.

Zhou, A. and Li, J. (2005) Arabidopsis BRS1 is an active and secreted serine carboxypeptidase. Journal of Biological Chemistry 280 (42), 35554-35561.

Xu, Y.Y., Wang, X.M., Li, J., Li, J.H., Wu, J.S., Walker, J.C., Xu, Z.H., Chong, K. (2005) Activation of the WUS gene induces ectopic initiation of floral meristems on mature stem surface in Arabidopsis thaliana.Plant Molecular Biology 57 (6), 773-784.

Wang, X.F., Goshe, M. B., Soderblom, E., Phinney, B.S., Kuchar, J., Li, J., Asami, T., Yoshida, S., Huber, S. C., Clouse, S. D. (2005) Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase. The Plant Cell 17(6), 1685-703.

Zhou, A., Wang, H., Walker, J.C., and Li, J. (2004) BRL1, a leucine-rich repeat receptor-like protein kinase, is functionally redundant with BRI1 in regulating Arabidopsis brassinosteroid signaling. The Plant Journal 40, 399-409.

Lee, G., Li, J., Walker, J.C. and Van Doren S.R. (2003) 1H. 13C and 15N resonance assignments of the kinase interacting FHA domain of Arabidopsis thaliana kinase-associated protein phosphatase.J. Biomol NMR 25, 253-254.

Li, J., Wen, J., Lease, K.A., Doke, J.T., Tax, F.E. and Walker, J.C. (2002) BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling. Cell 110, 213-222.

Lease, K.A., Wen, J., Li, J., Doke, J.T., Liscum, E. and Walker, J.C. (2001) A mutant Arabidopsis Heterotrimeric G protein b subunit affects leaf, flower and fruit development. The Plant Cell 13, 2631-2641.

Li, J., Lease, K.A., Tax, F.E. and Walker, J.C. (2001) BRS1, a serine carboxypeptidase, regulates BRI1 signaling in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 98, 5916-5921.

Li, J., Lee, G., Van Doren, S.R. and Walker, J.C. (2000) The FHA domain mediates phosphorylation-dependent protein-protein interactions. J. Cell Sci. 113, 4143-4149.

Li, J., Smith, G.P. and Walker, J.C. (1999) Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96, 7821-7826.

Lin, Q., Li, J., Smith, R.D. and Walker, J.C. (1998) Molecular cloning and chromosomal mapping of type one serine/threonine protein phosphatases in Arabidopsis thaliana. Plant Mol. Biol. 37, 471-481.

Li, J., Hegeman, C.E., Hanlon, W.R., Lacy, G.H., Denbow, D.M. and Grabau, E.A. (1997) Secretion of active recombinant phytase from soybean cell-suspension cultures.Plant Physiol. 114, 1103-1111.

Li, J. and Grabau, E.A. (1996) Comparison of somatic embryogenesis and embryo conversion in commercial soybean cultivars. Plant Cell, Tissue Organ Cult. 44, 87-89.

研究方向

1 ）油菜素內酯的信號傳遞、合成、及代謝途徑的分子調控機制 (Brassinosteroid Signal Transduction and Homeostasis): 油菜素內酯是一類重要的植物激素，參與調控植物生長的各個階段，阻斷油菜素內酯的生物合成或信號轉導都會使植物變得極其矮小，并表現出雄性不育、推遲衰老、在黑暗培養時呈現出去黃化等的異常表型。油菜素內酯的受體是一個跨膜的亮氨酸富集型受體激酶，它的胞外特定結構域能特意與油菜素內酯相互作用從而啟動胞內一系列磷酸化、脫磷酸化反應，把信號一步步傳到細胞核中，最終改變基因的表達。在過去的十年中，本研究小組利用激活標簽遺傳學手段成功地分離到多個關鍵蛋白 ( 比如： BRS1 ， BAK1 ， AtSERK1 ， BRL1 ， BRL3 ， BEN1 等 ) ，研究表明它們參與油菜素內酯的信號轉導、合成、及代謝調控。利用經典遺傳學及生物化學手段，本實驗室清楚地證明了BAK1在油菜素內酯信號早期階段起必不可少的作用。現階段的工作集中在利用遺傳、生化、蛋白組學等方法繼續發現參與油菜素內酯信號轉導、合成、及代謝調控的新蛋白，并對以往實驗室已發現蛋白所參與的具體作用機制作深入細致的探討。同時，我們也密切關注不同植物激素之間通過互作來調控植物的生長發育及逆境適應的分子機理。

2 ）用遺傳及生化手段研究擬南芥中一類亮氨酸富集型受體蛋白激酶的生物學功能 (Functional Analyses of LRR-RLKs): 細胞與細胞之間的信號轉導是高等植物生長發育的細胞生物學基礎，受體激酶在信號轉導過程中起至關重要的作用，它們通常作為信號轉導的原初受體。過去的十幾年中本實驗室做了大量的前期工作，克隆了擬南芥基因組中全部223個編碼亮氨酸富集型受體蛋白激酶的大多數全長 cDNA ，克隆并建立了全部223個LRR-RLK的promoter-GUS轉基因植株，對它們在不同發育階段的組織水平的轉錄表達進行了詳細的研究，對進一步了解它們真正的生物學功能奠定了良好的基礎。目前本實驗室正在利用各種遺傳學、分子生物學及組學手段對223LRR-RLKs中尚未揭示功能的分子開展生物學功能研究，已有多個尚未研究過的LRR-RLKs的功能被鑒定到，它們的具體分子機理正在研究之中。

3 ）受體激酶介導的植物細胞凋亡的分子機理 (RLK-Mediated Plant Cell-Death Control): 我們前面的工作已發現受體激酶 BAK1 及 BKK1 能同時參與正向調控油菜素內酯信號轉導，同時抑制細胞凋亡，同時敲除 BAK1 和 BKK1 使植物變得極其矮小，并在光下很快進入細胞凋亡過程，造成葉片快速死亡。我們目前正在對 BAK1 及 BKK1 調控細胞凋亡的分子機理作深入的探索。通過傳統遺傳學手段，我們已發現了多個能抑制雙突變體bak1 bkk1細胞死亡的遺傳抑制子，它們的具體作用機制還在研究中。

項目成果

科研項目：

1）國家基金委重大研究計劃重點項目“TCP類轉錄因子在調控油菜素內酯生物合成及信號轉導中的作用機理”， 90917019，2010.1.1到2013.12.31， 課題負責人：黎家

2）國家基金委重大研究計劃集成項目“油菜素內酯生物合成調控的分子機理”，91117008， 2012.1.1到2013.12.31，課題負責人： 黎家

3）科技部國家基礎研究發展計劃“高等植物蛋白質修飾與降解調控的分子機理研究”項目（項目負責人：謝旗）中的課題之一“植物蛋白的修飾的重要過程與調控機理”，2011CB915401，2011.1.1到2015.12.31, 課題負責人：黎家

4）國家基金委重大研究計劃集成項目“BAK1調控油菜素內酯信號轉導及器官發育的分子機制”，91317311，2014.1.1到2015.12.31，課題負責人: 黎家

榮譽、獲獎 Virginia Tech農學與生命科學學院杰出校友獎（2013-2014年度）； 蘭州大學“師德標兵”（2013）；中組部“****”特聘專家（2012年）；科學中國人（2011年）年度人物獎； 甘肅省領軍人才（2010年，2014年）； 教育部 "長江學者獎勵計劃"特聘教授 （2008年）；蘭州大學“萃英”特聘教授（2009）；Oklahoma 大學青年教師獎（2003）。

社會工作

中國植物生理學會常務理事, 中國細胞生物學會理事, Food and Energy Security 副主編, Journal of Integrative Plant Biology 編委,“細胞活動與逆境適應”教育部重點實驗室主任等

其它信息

CONTACT INFORMATION:
Dr. Jia Li, School of Life Sciences, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, People's Republic of China

Lab web page: www.lilab.cn; Email: lijia@lzu.edu.cn; Office phone: 0931-8915662