蘭州大學基礎醫學院導師介紹：王凱榮

導師信息來源：中國考研網 2015-07-29　相關院校：蘭州大學

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王凱榮，男，博士，副教授，碩士生導師。 2009 年于蘭州大學獲得理學博士學位，同年留校在醫學生物化學與分子生物學研究所從事教學科研工作，主要從事多肽藥物分子設計、合成及抗菌肽抗腫瘤、抗菌、抗真菌、抗病毒活性、作用機制及構效關系研究。2012年獲第十二屆中國國際多肽學術會議青年論文獎（Young Peptide Scienctist Award）;2013年10月獲第十二屆張錫均基金會全國青年優秀生理學學術論文優秀口頭報告獎（中國生理學會）。
郵箱: wangkr@lzu.edu.cn

大學開始受教育經歷

2000.9-2004.7 西北師范大學生命科學學院，獲得學士學位。
2004.9-2009.7 蘭州大學生命科學學院，生物化學與分子生物學專業，獲得博士學位。

研究工作經歷

2009.7—2012.5 蘭州大學，基礎醫學院/甘肅省新藥臨床前研究重點實驗室,講師；
2012.5— 蘭州大學，基礎醫學院/甘肅省新藥臨床前研究重點實驗室，副教授，碩士生導師。

在研項目：

1.教育部“春暉計劃”合作科研項目“抗菌肽優化設計合成、構效關系及膜-肽作用分子動力學機制研究”（No.Z2010082）， 2011.7—2013.7；
2.教育部博士點新教師基金項目“抗菌肽polybia-MPI 的新型類似物的設計合成、抗菌活性及構效關系研究”（No.20120211120045）， 2013.1-2015.12；
3.國家自然科學基金青年基金項目“以細胞膜為靶標的新型抗菌肽polybia-MPI類似物的設計、合成及抗菌活性研究”（No.31200584）, 2013.01-2015.12；
4.蘭州大學中央高校自由探索面上項目“新型抗菌肽氟代衍生物抗真菌活性、作用機制及構效關系研究”(No.lzujbky-2013-164)，2013.1-2014.6。

已發表論文目錄:

1. Kairong Wang, JX Yan, W Dang, JQ Xie, Bo Yan, Wenjin Yan, et al. Dual Antifungal properties of Cationic Antimicrobial Peptides Polybia-MPI: Membrane Integrity Disruption and Inhibition of Biofilm Formation. Peptides 2014, 10.1016/j.peptides.2014.03.005. (SCI)
2. Kairong Wang, W Dang, JX Yan, R Chen, X Liu, WJ Yan, et al. Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Antimicrobial Agents and Chemotherapy, 2013,57(10), 4632–9. (SCI二區， IF=4.841)
3. Kairong Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, W Yan, Z Yang, J Xie, Rui Wang. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88. （SCI三區，IF=2.421）
4. J Yan1, Kairong Wang1, W Dang, R Chen, J Xie, B Zhang, J Song, Rui Wang. Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin. Antimicrob. Agents Chemother., 2013; 57: 220 - 228. (并列第一作者，SCI二區，IF=4.841)
5. D Wang, J Liang, J Feng, Kairong Wang, Q Sun, L Zhao, D Li, W Yan and Rui Wang. The Quinine Thiourea-Catalyzed Asymmetric Strecker Reaction: An Approach for the Synthesis of 3-Aminooxindoles. Adv. Synth. Catal. 2013, 355:548-58. （SCI二區, IF=6.048）
6. Kairong Wang, J Yan, R Chen, W Dang, B Zhang, W Zhang, J Song, Rui Wang. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista. Antimicrob. Agents Chemother., 2012; 56: 3318 - 3323. （SCI二區， IF=4.841）
7. J Yan1, Kai-rong Wang1, J Song, R Chen, B Zhang, W Zhang, W Dang, Rui Wang. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie 2012,94 184-191. (SCI三區, 并列第一作者，IF =3.787).
8. Kairong Wang, J Yan, X Liu, J Zhang, R Chen, B Zhang, W Dang, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social sasp polybia paulista. Toxicology, 2011, 288; 27-33. (SCI二區, IF =4.01)
9. B Zhang1, Kai-rong Wang1, W Zhang, J Yan, J Song, Rui Wang . In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides. 2010,31, 568–573. (SCI三區，并列第一作者, IF =2.434)
10. Rui Wang, Kairong Wang. Peptides: Chemistry, Biology and Pharmaceutical Sciences, Chemical Industry Press, 2011.
11. B Zhang, Kairong Wang, Z Wang, X Li, X Wang, J Ni. Design, synthesis and in vitro antitumor activity of novel actinomycin D analogs. Chemical Journal of Chinese Universites. 2010,31,1346-1352.（SCI三區, IF =0.855）
12. Kai-rong Wang, J Yan, B Zhang, J Song, P Jia, Rui Wang. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer lett. 2009, 278,65-72.(SCI二區, IF =4.238)
13. Kai-rong Wang, B Zhang, J Yan, X Li, Rui Wang. Potent antitumor effects of a novel actinomycin D analog Leu5AMD, Cancer lett. 2008,268,38-45. (SCI二區, IF =4.238)
14. Kai-rong Wang, Bang-zhi Zhang, Jie-xi Yan, Jia Li, Rui Wang. Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides. 2008,29,963-8. (SCI三區, IF 2.434).
15. C Fu, Z Kong1, Kai-rong Wang1, Q Yang, K Zhai, Q Chen, Rui Wang. Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Res.,2005,1056,51-58.(SCI三區, IF 2.434,)
16. C Fu1, Q yang1, Kai-rong Wang, Z Kong, Q Chen, Rui Wang. Rat/mouse hemokinin-1, a mammalian tachykinin peptide, markedly potentiates the antinociceptive effects of morphine administered at the peripheral and supraspinal level. Behavioural Brain Research, 2006, 170: 293-301. (SCI三區, IF 3.393)
17. W Zhang, J Li, L Liu, Kai-rong Wang, J Song, J Yan, Z Li, B Zhang, RuiWang. A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic ef?cacy against cancer and diminished toxicity in mice. Peptides. 2010,31,1832–1838.（SCI三區, IF =2.434）
18. W Zhang, J Song, B Zhang, L Liu, Kairong Wang, Rui Wang. Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells. Bioconjugate Chem., 2011, 22 (7), 1410–1415 (SCI二區，IF=4.93)
19. W Zhang, J Song, L Mu, B Zhang, L Liu, Y, Xing, Kai-rong Wang, Z Li, Rui Wang. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P. Bioorganic & Medicinal Chemistry Letters. 2011, 21(5):1452-5 (SCI三區, IF=2.661)
20. Y Sun, X Zhang, N He, T Sun, Y Zhuang, Q Fang, Kai-rong Wang, Rui Wang. Neuropeptide FF activates ERK and NF kappa B signal pathways in differentiated SH-SY5Y cells. Peptides, 2012, 38, 110–117.（SCI三區，IF=2.434）.