蘭州大學(xué)基礎(chǔ)醫(yī)學(xué)院導(dǎo)師介紹：張偉

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張偉，博士，講師。2011年于蘭州大學(xué)生命科學(xué)院獲得博士學(xué)位。2011-2013年在蘭州大學(xué)第一臨床醫(yī)學(xué)院從事博士后研究。
 
科研方向：

1.  抗菌肽藥物的設(shè)計(jì)及多功能研究                                      
發(fā)展多類高效低毒的抗菌肽藥物，用于腫瘤、細(xì)菌感染以及炎癥的治療。
2.  多肽載體的設(shè)計(jì)及應(yīng)用                                       
基于穿膜肽發(fā)展高效低毒的載體，用于基因和抗腫瘤藥物的的靶向運(yùn)輸。
 
榮譽(yù)稱號(hào)及獎(jiǎng)勵(lì)：

1.  2013年，中國藥學(xué)會(huì)科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)（第五完成人）
                                                                                                        
主持的科研項(xiàng)目：

1.  主持中國博士后科學(xué)基金特別資助一項(xiàng)（2013T60896），雙功能抗菌肽的設(shè)計(jì)及抗菌活性研究， 2013.5-2014.12
 
2.  主持中國博士后科學(xué)基金面上資助一項(xiàng)（2012M512047），新型酸激活基因載體的設(shè)計(jì)及應(yīng)用，2012.5-2013.12
 
參與科研項(xiàng)目情況：

1.以項(xiàng)目組主要成員（2/9）參與國家自然科學(xué)基金委——面上項(xiàng)目一項(xiàng)（81273440），高穩(wěn)定性酸敏感穿膜肽的設(shè)計(jì)與應(yīng)用，2013.1-2016.12
2.以項(xiàng)目組主要成員（2/8）參與國家自然科學(xué)基金委——青年科學(xué)基金項(xiàng)目一項(xiàng)（81202400），具有重要醫(yī)藥用途的神經(jīng)肽的化學(xué)修飾及作用機(jī)制研究，2013.1-2015.12
 
發(fā)表論文：

1.Zhang Wei, Song JJ, Liang RR, Zheng X, Chen JB, Li GL, Zhang BZ, Yan X, Wang R*. Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. Bioconjugate Chem, 2013. (accepted) (SCI二區(qū)，影響因子4.58)
2. 張偉, 宋竟婧, 張邦治, 楊雯樂, 王 銳*. 多肽新藥研發(fā)策略的研究進(jìn)展. 中國科學(xué):化學(xué), 2013, 43, 939-940.
3. Zhang Wei, Song JJ, Liang RR, Zheng X, Chen JB, Li GL, Zhang BZ, Wang KR, Yan X, Wang R*. Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer. Peptides, 2013, 46C:33-39. (SCI三區(qū)，影響因子2.522)
4.Zhang Wei, Song Jingjing, Zhang BZ, Liu LW, Wang KR, Wang R*. Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells. Bioconjugate Chem, 2011, 22:1410-1415. (SCI二區(qū)，影響因子4.58)
5.Zhang Wei, Song JJ, Mu LY, Zhang BZ, Liu LW, Xing YH, Wang KR, Li ZY, Wang R*. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P. Bioorg Med Chem Lett, 2011, 21:1452-1455. (SCI三區(qū)，影響因子2.338)
6.Zhang Wei, Li J, Liu LW, Wang KR, Song Jingjing, Yan JX, Li ZY, Zhang BZ, Wang R*. A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. Peptides, 2010, 31:1832-1838. (SCI三區(qū)，影響因子2.522)
7. Song J, Zhang Wei, Kai M, Chen J, Liang R, Zheng X, Li G, Zhang B, Wang K, Zhang Y, Yang Z, Ni J, Wang R. Design of an Acid-Activated Antimicrobial Peptide for Tumor Therapy. Mol Pharm. 2013,10: 2934-2941 (共同第一作者) (SCI二區(qū)，影響因子4.57)
8.Xing Y, Zhang Wei, Song J, Zhang Y, Jiang X, Wang R. Anticancer effects of a novel class rosin-derivatives with different mechanisms. Bioorg Med Chem Lett. 2013, 23:3868-72. (共同第一作者) (SCI三區(qū)，影響因子2.338)
9.Liu J, Zhang Wei, Zhang H, Yang Z, Li T, Wang B, Huo X, Wang R, Chen H. A multifunctional nanoprobe based on Au-Fe3O4 nanoparticles for multimodal and ultrasensitive detection of cancer cells. Chem Commun (Camb). 2013, 49:4938-40. (SCI二區(qū)，影響因子6.378)
10. Zhi LH, Liu J, Wang Y, Zhang Wei, Wang BD *, Xu ZG, Yang ZY, Huo X, Li GM. Multifunctional Fe3O4 nanoparticles for highly sensitive detection and removel of Al(III) in aqueous solution. Nanoscale, 2013, 5:1552-1556. (SCI一區(qū)，影響因子6.233)
11. Wang K, Yan J, Dang W, Liu X, Chen R, Zhang J, Zhang B, Zhang Wei, Kai M, Yan W, Yang Z, Xie J, Wang R*. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides, 2013, 39:80-8. (SCI三區(qū)，影響因子2.522)
12.Wang KR, Yan JX, Chen R, Dang W, Zhang BZ, Zhang Wei, Song JJ, Wang R*. Membrane-active action mode of Polybia-CP, a novel antimicrobial peptide isolated from the venom of Polybia Paulista. Antimicrob Agents Chemother, 2012, 56:3318-3323. (SCI二區(qū)，影響因子4.565)
13.     Yan JX, Wang KR, Chen R, Song JJ, Zhang BZ, Dang W, Zhang Wei, Wang R*. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie, 2012, 94:184-191. (SCI三區(qū)，影響因子3.142)
14.Song Jingjing, Kai M, Zhang Wei, Zhang JD, Liu LW, Zhang BZ, Liu X, Wang R*. Cellular uptake of transportan 10 and its analogs in live cells: Selectivity and structure–activity relationship studies. Peptides, 2011, 32:1934-1941. (SCI三區(qū)，影響因子2.522)
15.Wang KR, Yan JX, Liu X, Zhang JD, Chen R, Zhang BZ, Dang W, Zhang Wei, Kai M, Song Jingjing, Wang R*. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social wasp Polybia paulista. Toxicology, 2011, 288:27-33. (SCI二區(qū)，影響因子4.017)
16.Zhang BZ, Wang KR, Yan JX, Zhang Wei, Song Jingjing, Ni JM, Wang R*. In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides, 2010, 31:568-573. (SCI三區(qū)，影響因子2.522)
17.Wang KR, Zhang BZ, Zhang Wei, Yan JX, Li XL, Wang R*. Potent antitumor effects of a novel actinomycin D analog Leu5AMD. Cancer Lett, 2008, 268:38-45. (SCI二區(qū)，影響因子4.258)
18.Wang KR, Zhang BZ, Zhang Wei, Yan JX, Li J, Wang R*. Antitumor effects, cell selectivity and structure-activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides, 2008, 29:963-938. (SCI三區(qū)，影響因子2.522)
 
專利：

[1]王銳，宋竟婧，張偉，開明，張邦治；“具有酸激活特性的抗菌肽AMitP及其合成和在制備抗腫瘤藥物中的應(yīng)用”，2012，中國，申請(qǐng)?zhí)枺?01210221080.4
[2]王銳，張偉，宋竟婧，張邦治；“基于N末端18烷酰化抗菌肽構(gòu)建的非病毒基因載體”，2012，中國， 申請(qǐng)?zhí)枺?01210221082.3 申請(qǐng)日期：2012.06.29