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華東理工大學(xué)生物工程學(xué)院生物工程研究生導(dǎo)師：莊英萍

導(dǎo)師信息來(lái)源：華東理工大學(xué) 2019-01-25　相關(guān)院校：華東理工大學(xué)

華東理工大學(xué)生物工程學(xué)院生物工程研究生導(dǎo)師莊英萍介紹如下：

莊英萍

生物工程專業(yè)：博士生導(dǎo)師/碩士生導(dǎo)師

生物化工專業(yè)：博士生導(dǎo)師

微生物學(xué)專業(yè)：碩士生導(dǎo)師

生物工程領(lǐng)域：工程碩士生導(dǎo)師

食品工程領(lǐng)域：工程碩士生導(dǎo)師

博士，研究員，博導(dǎo)。1962年生，1984年畢業(yè)于華東化工學(xué)院生化工程專業(yè)后立留任任教，1997年獲華東理工大學(xué)生化工程碩士學(xué)位，2006年獲華東理工大學(xué)生物化工博士學(xué)位現(xiàn)任華東理工大學(xué)生物工程學(xué)院院長(zhǎng)，國(guó)家生化工程技術(shù)研究中心（上海）主任，上海生物制造產(chǎn)業(yè)技術(shù)研究院副院長(zhǎng)，“ 863”生物與醫(yī)藥領(lǐng)域工業(yè)生物技術(shù)主題專家，中國(guó)微生物學(xué)會(huì)第十屆理事會(huì)常務(wù)理事，生化過(guò)程模型化與控制專業(yè)委員會(huì)主任委員，中國(guó)化工學(xué)會(huì)生物化工專業(yè)委員會(huì)副主任委員。

長(zhǎng)期來(lái)主要從事發(fā)酵過(guò)程的優(yōu)化與放大研究，在國(guó)家生物反應(yīng)器工程重點(diǎn)實(shí)驗(yàn)室和國(guó)家生化工程技術(shù)研究中心（上海）的工作中，在“十一五”期間，完成了“ 973”項(xiàng)目“工業(yè)生物技術(shù)的過(guò)程科學(xué)基礎(chǔ)研究-生化反應(yīng)過(guò)程放大原理與方法”（課題編號(hào)：2007CB714303，課題負(fù)責(zé)人）‘十二五’期間作為項(xiàng)目負(fù)責(zé)人，承擔(dān)了上海市科委基地建設(shè)項(xiàng)目“上海生物過(guò)程工程專業(yè)服務(wù)平臺(tái)再建設(shè)”（項(xiàng)目負(fù)責(zé)人，課題編號(hào)：11DZ2292700，13DZ2290500），并作為主要參加者，參加了‘十一五’ 863重點(diǎn)項(xiàng)目“頭孢菌素ç發(fā)酵工業(yè)用菌種改造和代謝工程技術(shù)“，”紅霉素發(fā)酵工業(yè)用菌種改造與過(guò)程優(yōu)化控制技術(shù)“，”十二五“期間” 863項(xiàng)目：生物過(guò)程關(guān)鍵技術(shù)及裝備研發(fā)“，” 973項(xiàng)目：工業(yè)生物過(guò)程高效轉(zhuǎn)化與系統(tǒng)集成的科學(xué)基礎(chǔ)研究”等重大項(xiàng)目。在長(zhǎng)期研究中本人所在的研究團(tuán)隊(duì)，圍繞著工業(yè)生物過(guò)程的基礎(chǔ)研究，關(guān)鍵共性技術(shù)研究和技術(shù)推廣開(kāi)展了大量工作，在多尺度發(fā)酵過(guò)程參數(shù)相關(guān)分析理論方法基礎(chǔ)上，又形成了基于細(xì)胞生理特性和反應(yīng)器流場(chǎng)特性相結(jié)合的工業(yè)生物過(guò)程優(yōu)化與放大理論與方法及其相關(guān)的裝備，并在紅霉素，頭孢菌素C，鳥(niǎo)苷，葡萄糖酸鈉，阿維菌素等數(shù)十個(gè)品種的工業(yè)發(fā)酵產(chǎn)品中成功應(yīng)用。本人在發(fā)酵過(guò)程的參數(shù)相關(guān)分析，發(fā)酵過(guò)程代謝調(diào)控和工業(yè)生物過(guò)程放大等方面形成了研究特色近年來(lái)獲得國(guó)家科技進(jìn)步二等獎(jiǎng)三項(xiàng)，上海市科技進(jìn)步一等獎(jiǎng)三項(xiàng)，中國(guó)產(chǎn)學(xué)研合作創(chuàng)新成果獎(jiǎng)一項(xiàng);發(fā)表論文150余篇，SCI收錄90余篇，獲授權(quán)發(fā)明專利25項(xiàng)。

電話：021-64251257，電子郵件：ypzhuang@ecust.edu.cn

獲獎(jiǎng)成果：

1，基于細(xì)胞生理與過(guò)程信息處理的工業(yè)發(fā)酵優(yōu)化新技術(shù)， 2011年國(guó)家科技進(jìn)步二等獎(jiǎng)，本人排名第三

2，基于參數(shù)相關(guān)的發(fā)酵過(guò)程生物反應(yīng)器優(yōu)化與放大技術(shù)， 2002年國(guó)家科技進(jìn)步二等獎(jiǎng)，本人排名第三

3，新型食品添加劑呈味核苷酸二鈉關(guān)鍵生產(chǎn)工藝， 2004年獲國(guó)家科技進(jìn)步二等獎(jiǎng)，本人排名第四

4，先進(jìn)技術(shù)集成的紅霉素生產(chǎn)新工藝， 2008年上海市科技進(jìn)步一等獎(jiǎng)，本人排名第三

5，基于細(xì)胞生理與過(guò)程信息處理的工業(yè)發(fā)酵優(yōu)化新技術(shù)， 2014年中國(guó)產(chǎn)學(xué)研究合作創(chuàng)新成果獎(jiǎng)，本人排名第五

發(fā)表論文情況（SCI選錄）：

1. Yong Chen, Zejiang Wang, Ju Chu*, Beili Xi, Yingping Zhuang. The glucose RQ-feedback control leading to improved erythromycin production by a recombinant strain Saccharopolyspora erythraea ZL1004 and its scale-up to 372-m(3) fermenter. Bioprocess & Biosystems Engineering. 2015, 38(1):105-112, DOI: 10.1007/s00449-014-1248-8
2. Hongzhong Lu，Chao Li，Wenjun Tang，Zejian Wang，Jianye Xia，Siliang Zhang，Yingping Zhuang，Ju Chu，Henk Noorman，Dependence of fungal characteristics on seed morphology and shear stress in bioreactor. Bioprocess & Biosystems Engineering. 2015, 38(5):917-928, DOI: 10.1007/s00449-014-1337-8
3. Wenjun Tang, Ao Pan, Hongzhong Lu, Yingping Zhuang, Siliang Zhang, Ju Chu, Henk Noorman, Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer. Biochemical Eneineering Journal. 2015, 99:167-176. DOI: 10.1016/j.bej.2015.03.025
4. Yang Liu, Xiaoping Yi, Yingping Zhuang, Siliang Zhang, Limitations in the process of transcription and translation inhibit recombinant human chorionic gonadotropin expression in CHO cells. Journal of Biotechnology. 2015, 204:63-69, DOI: 10.1016/j.jbiotec.2014.12.005
5. Yaosong Wang, Mingying Liu, Liming Zhao, Yongjun Qiu, Yingping Zhuang, Influence of processing conditions on reducing gamma-aminobutyric acid content during fortified milk production. Food Research International. 2015,72: 215-222, DOI: 10.1016/ j.foodres. 2015.04.004
6. Fei Lu, Kangkang Ping, Ling Wen, Wei Zhao, Zejian Wanga, Ju Chu,,Yingping Zhuang, Enhancing gluconic acid production by controlling the morphology ofAspergillus niger in submerged fermentation, Process Biochemistry, (50)2015,1342-1348
7. Zhi-Qiang Xiong, Mei-Jin Guo, Ju Chu, Ying-Ping Zhuang, Si-liang Zhang, On-line specific growth rate control for improving reduced glutathione production in Saccharomyces cerevisiae. Biotechnology & BioprocessS Engineering. 2015,20(5):887-893
8. Hongzhong Lu, Xiaoyun Liu, Mingzhi Huang, Jianye Xia, Ju Chu, Yingping Zhuang, Siliang Zhang, Henk Noorman, Integrated isotope-assisted metabolomics and C-13 metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger. 2015,Microbial Cell Factories. 14,147, DOI: 10.1186/s12934-015-0329-y
9. Yaosong Wang, Mingying Liu, Liming Zhao, Yongjun Qiu, Yingping Zhuang, Interactions of gamma-aminobutyric acid and whey proteins/caseins during fortified milk production. RSC Advances.5(111):91235-91245
10. Xiangyun Lv, Yuanxin Guo, Yingping Zhuang*, Yonghong Wang*, Optimization and validation of an extraction method and HPAEC-PAD for determination of residual sugar composition in L-lactic acid industrial fermentation broth with a high salt content. Analytical Methods. 2015, 7(21):9076-9083
11. Fei Shi, Jun Tan, Ju Chu, Yonghong Wang, Yingping Zhuang, Siliang Zhang. A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger. Journal of Microbiologcal Methods. 109:134-139, DOI: 10.1016/ j.mimet.2014.12.004
12. Guan Wang, Ju Chu, Henk Noorman, Jianye Xia, Wenjun Tang, Yingping Zhuang, Siliang Zhang. Prelude to rational scale-up of penicillin production: a scale-down study. Applied Microbiology and Biotechnolog. 2014,    DOI:10.1007/s00253-013-5497-2
13. Minghui Xie, Jianye Xia*, Zhen Zhou, Ju Chu, Yingping Zhuang, Siliang Zhang, Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors. Industrial & Engineering Chemistry Research. 2014, 53(14): 5941-5953, DOI: 10.1021/ie400831s
14. Minghui Xie, Jianye Xia*, Zhen Zhou,Zhou Guozhong, Ju Chu, Yingping Zhuang, Siliang Zhang, Henk Noorman, Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions. Chemical Engineering Science. 2014, 106:144-`56. DOI: 10.1016/j.ces.2013.10.032
15. Lan Li, Zejian Wang*, Xuejun Chen, Ju Chu, Yingping Zhuang, Siliang Zhang, Optimization of polyhydroxyalkanoates fermentations with on-line capacitance measurement. Bioresource Technology. 2014, 156:216-221. DOI: 10.1016/j.biortech.2014.01.042
16. Lei Deng, Bingyang Shi, Yingping Zhuang, Ju Chu, Xiaolin Shi, Siliang Zhang, Meijin Guo*, Performance and Mechanism of Neuroleukin in the Growth and Survival of Sertoli Cell-Induced Neurons in a Coculture System. Cell Transplantation. 2014, 23(3):   381-394, DOI: 10.3727/096368913X663578
17. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang,. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on L-lactic acid production efficiency by Lactobacillus paracasei. Process Biochemistry. 2014,49(12): 2049-2054, DOI: 10.1016/j.procbio.2014.06.014
18. Yongsheng Nie, Mingzhi Huang*, Junjie Lu, Jiangchao Qian, Weilu Lin, Ju Chu, Yingping Zhuang, Siliang Zhang. Impacts of high beta-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via C-13 metabolic flux analysis. Journal of Biotechnology. 2014, 187:124-134, DOI: 10.1016/j.jbiotec.2014.07.011
19. Xiaoqing Hu, Ju Chu, Siliang Zhang, Yingping Zhuang, Xin Wu, Huaxin Chen, Zhongyuan Lv, Zhongyi Yuan. An alkaline pH control strategy for methionine adenosyltransferase production in Pichia pastoris fermentation. Biotechnology & Bioprocess Engineering. 2014, 19(5): 900-907, DOI: 10.1007/s12257-014-0046-0
20. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang,. L-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination. Bioprocess & Biosystems Engineering. 2014, 37(9): 1917-1923, DOI: 10.1007/s00449-014-1166-9
13. Taicheng Zhu, Haifeng Hang, Ju Chu, Yingping Zhuang, Siliang Zhang, Meijin Guo. Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichia pastoris. Journal of Industrial Microbiology & Biotechnology. 2013, 40(2) : 183-189   DOI: 10.1007/s10295-012-1225-7
14. Ju Chu, Jiangchao Qian, Yingping Zhuang, Siliang Zhang. Progress in the research of S-adenosyl-L-methionine production. Applied Microbiology Biotechnology. 2013, 97(1):41-49   DOI: 10.1007/s00253-012-4536-8
15. Yong Chen,Mingzhi Huang,Zejian Wang,Ju Chu,Yingping Zhuang,Siliang Zhang, Controlling the feed rate of glucose and propanol for the enhancement of erythromycin production and exploration of propanol metabolism fate by quantitative metabolic flux analysis. Bioprocess and Biosystems Engineering. 2013, 36(10): 1445-1453
16. Jun Tan,Ju Chu,Yuyou Hao,Yuanxin Guo,Yingping Zhuang,Siliang Zhang, High-Throughput System for Screening of Cephalosporin C High-Yield Strain by 48-Deep-Well Microtiter Plates. Applied Biochemistry and Biotechnology. 2013, 169(5): 1683-1695
17. Chao Li, Jianye Xia*, Ju Chu, Yonghong Wang*, Yingping Zhuang,; Siliang Zhang, CFD analysis of the turbulent flow in baffled shake flasks. Biochemical Eneineering Journal. 2013, 70:140-150
18. Yong Chen, Zejian Wang, Ju Chu, Yingping Zhuang, Siliang Zhang, Yu Xiaoguan, Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate. Bioresource Technology. 2013,134:173-179. DOI: 10.1016/j.biortech.2013.02.023
19. Xiang Zou,Wanjun Li,Wei Zeng,Haifeng Hang,Ju Chu,Yingping Zhuang,Siliang Zhang, Biochemical Parameters of Saccharopolyspora Erythraea during Feeding Ammonium Sulphate in Erythromycin Biosynthesis Phase. Applied Biochemistry & Microbiology. 2013,49(2): 169-175   DOI: 10.1134/S0003683813020166
20. Xiang Zou, Wanjun Li, Wei Zeng, Hangfeng Hang, Ju Chu, Yingping Zhuang, Siliang Zhang. Biochemical Parameters of Saccharopolyspora Erythraea during Feeding Ammonium Sulphate in Erythromycin Biosynthesis Phase. Applied Biochemistry & Microbiology. 2013, 49(2):169-175. DOI: 10.1134/S0003683813020166
21. Xiaoqing Hu, Ju Chu. Siliang Zhang. Yingping Zhuang, Comparative performance of S-adenosyl-L-methionine biosynthesis and degradation in Pichia pastoris using different promoters and novel consumption inhibitors. 2013, Enzyme & Microbial Technology. 55:94-99. DOI: 10.1016/j.enzmictec.2013.09.003
22. .Xiang Zou, Jian-ye Xia, Ju Chu, Ying-ping Zhuang, Si-liang Zhang, Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m(3) fermenter. Bioprocess & Biosystem Engineering, 2012, 35:789–800
23. Yue Hugh Guan, Remco N. A. M van den Heuvel, Ying-Ping Zhuang, Visualisation of J-type counter-current chromatography: A route to understand hydrodynamic phase distribution and retention. Journal of Chromatography A . 2012, 1239:10-21
24. Lan Yu, Nan Cao, Long Wang, Ciying Xiao, Meijin Guo, Ju Chu, Yingping Zhuang, Siliang Zhang, Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes. Enzyme & Microbial Technology, 2012, 50(6-7): 318-324
25. Ze-Jian Wang, Ping Wang, Yu-Wei Liu, Yi-Ming Zhang, Ju Chu, Ming-zhi Huang, Yingping Zhuang, Siliang Zhang, Metabolic flux analysis of the central carbon metabolism of the industrial vitamin B-12 producing strain Pseudomonas denitrificans using C-13-labeled glucose. Journal of the Taiwan Institute of Chemical Engineers. 2012, 43(2): 181-187
26. Dan Wu, Ju Chu, Yu-You Hao, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang, Incomplete protein disulphide bond conformation and decreased protein expression result from high cell growth during heterologous protein expression in Pichia pastoris. Journal of Biotechnology. 2012,157(1):107-112
27. Yiming Yang, Jianye Xia, Jianhua Li ,Ju Chu, Liang Li, YonghongWang, Yingping Zhuang ,Siliang Zhang, A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production, Journal of Biotechnology. 2012, 161(3) : 250-256   DOI: 10.1016/j.jbiotec.2012.07.007
28. Jun Tan, Ju Chu, Wenjuan Shi, Cheng Lin, Yuanxin Guo, Yingping Zhuang, Siliang Zhang, Tadayuki I manaka. High-throughput screening strategy used for enhanced production of pigment by Monascus purpureus D39-4. Food Science and Biotechnology. 2012, 21(6): 1603-1610   DOI: 10.1007/s10068-012-0213-z
29. Xiang Zou, Wan-jun Li, Wei Zeng, Ju Chu, Ying-ping Zhuang, Si-liang Zhang. An assessment of seed quality on erythromycin production by recombinant Saccharopolyspora erythraea strain . Bioresource Technology , 2011,102(3): 3360-3365
30.Xu Li , Yonghong, Siliang, Ju Chu , Ming Zhang , Mingzhi Huang , Yingping Zhuang. Effects of light/dark cycle, mixing pattern and partial pressure of H-2 on biohydrogen production by Rhodobacter sphaeroides ZX-5. Bioresource Technology , 2011,102(2): 1142-1148
31. Taicheng Zhu , Meijin Guo , Yingping Zhuang , Ju Chu , Siliang Zhang. Understanding the effect of foreign gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes. Applied Microbiology & Biotechnology. 2011, 89(4): 1127-1135
32.Xiulin Qin, Jiangchao Qian*, Gaofeng Yao, Yingping Zhuang, Siliang Zhang, and Ju Chu, GAP Promoter Library for Fine-Tuning of Gene Expression in Pichia pastoris. Applied and Environmental Microbiology, 2011, 77(11):3600-3608
33.Suwen Hu, Lei Deng, Huamao Wang, Yingping Zhuang, Ju Chu, Siliang Zhang, Zhonghai Li, Meijin Guo. Bioprocess development for the production of mouse-human chimeric anti- epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells. Cytotechnology. 2011,63(3): 247-258
34. Xu Li, Huan Shi,, Yonghong Wang, , Siliang Zhang, Ju Chu, Ming Zhang,   Mingzhi Huang, Yingping Zhuang, , Effects of vitamins (nicotinic acid, vitamin B(1) and biotin) on phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5. International Journal of Hydrogen energy, .2011,36(16) : 9620-9625
35. Dan Wu, Ju Chu, Yu-You Hao, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang, High efficient production of recombinant human consensus interferon mutant in high cell density culture of Pichia pastoris using two phases methanol control. Process Biochemistry. 2011,46(8): 1663-1669
36. Zhenyu Tang, Ciying Xiao, Yingping Zhuang, Ju Chu, Siliang Zhang, Herron, Paul R., Hunter, Iain S., Meijin Guo, Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway, Enzyme & Microbial Technology, 2011, 49(1): 17-24
37. Jian-Guang Liang, Xiao-He Chu, , Zhi-Qiang Xiong, Ju Chu, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang, Oxygen uptake rate regulation during cell growth phase for improving avermectin B(1a) batch fermentation on a pilot scale (2 m(3)). World Journal of Microbiology & Biotechnology, 2011, 27(11) : 2639-2644
38. Dan Wu, Ju Chu, Yu-You Hao, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang, Incomplete protein disulphide bond conformation and decreased protein expression result from high cell growth during heterologous protein expression in Pichia pastoris. J. Biotechnology, 2011. 157(1):107-112
39. Yifeng Lu ,Yonghong Wang, Guoqian Xu , Ju Chu, Yingping Zhuang , Siliang Zhang,Influence of High Solid Concentration on Enzymatic Hydrolysis and Fermentation of Steam-Exploded Corn Stover Biomass. Appl Biochem Biotechnol, 2010, 160:360–369
40. Yong-Hong Wang, Chun-Hai Wu, Ju Chu, Yu-You Hao, Ying-Ping Zhuang , Si-Liang Zhang, Regulation of branched-chain amino acid catabolism: glucose limitation enhances the component of isovalerylspiramycin for the bitespiramycin production. Bioprocess & Biosystem Engineering, 2010, 33:257–265
41. Dan Wu, Dong Ma, Yu-You Hao, Ju Chu, Yong-Hong, Wang，Ying-Ping Zhuang , Si-Liang Zhang, Incomplete formation of intramolecular disulfide bond triggers degradation and aggregation of human consensus interferon-α mutant by Pichia pastoris. Appl Microbiol Biotechnol , 2010, 85:1759–1767
42. Ze-Jian Wang, Hui-Yuan Wang , Yong-Liang Li, Ju Chu , Ming-Zhi Huang, Ying-Ping Zhuang, Si-Liang Zhang, Improved vitamin B12 production by step-wise reduction of oxygen uptake rate under dissolved oxygen limiting level during fermentation process. Bioresource Technology , 2010,101: 2845–2852
43. Wang, Yong, Zhuang, Ying-ping, Wang, Ping, Chu, Ju, Zhang, Si-liang. Regulation of meilingmycin in Streptomyces nanchangensis: Effect of ammonium ion, Korean Journal of Chemical Engineering. 2010, 27(3): 910-914
44. Jianhua Li,Yiming Yang, Ju Chu,Mingzhi Huang, Lan Li,Xiaochun Zhang,Yonghong Wang , Yingping Zhuang ,Siliang Zhang ,Quantitative metabolic flux analysis revealed uneconomical utilization of ATP and NADPH in Acremonium chrysogenum fed with soybean oil, Bioprocess & Biosystems Engineering, 2010, 33(9) :1119-1129
45. Xiang Zou,Changfa Chen,Haifeng Hang,Ju Chu,Yingping Zhuang,Siliang Zhang , Response Surface Methodology for Optimization of the Erythromycin Production by Fed-Batch Fermentation Using an Inexpensive Biological Nitrogen Source, Chemical & Biochemical Engineering Quarterly. 2010, 24( 1): 95-100
46. Ziqiang Xiong, Meijin Guo , Yuanxin Guo ,Ju Chu,Yingping Zhuang ,Siliang Zhang , RQ feedback control for simultaneous improvement of GSH yield and GSH content in Saccharomyces cerevisiae T65, Enzyme & Microbial Technology. 2010, 46( 7) : 598-602
47. Dan Wu, Ju Chu, Yu-You Hao, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang .Influence of Specific Growth Rate on Specific Productivity and Intermolecular disulfide bond of Recombinant Protein Produced by a Pichia pastoris Mut(+) Strain. Journal of Biotechnology, 2010, 150: S540-S540
48. Xiang Zou, Wei Zeng , Chang-fa Chen, Xia-chang Qi , Jiang-chao Qian, Ju Chu, Ying-ping Zhuang, Si-liang Zhang , Wan-jun Li, Fermentation Optimization and Industrialization of Recombinant Saccharopolyspora erythraea Strains for Improved Erythromycin A Production. Biotechnology & Bioprocess Engineering. 2010, 15(6): 959-968
49. Xiang Zou , Hai-feng Hang , Ju Chu, Ying-ping Zhuang, Si-liang Zhang, Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale. Bioresource Technology. 2009, 100 (3) :1406–1412
50. Jin Zhou, Yong-Hong Wang, Ju Chu, Ling-Zhi Luo, Ying-Ping Zhuang, Si-Liang Zhang,Optimization of cellulase mixture for efficient hydrolysis of steam-exploded corn stover by statistically designed experiments.Bioresource Technology ,2009,100 :819–825
51. Zhi-Qiang Xiong, Mei-Jin Guo , Yuan-Xin Guo, Ju Chu, Ying-Ping Zhuang, Si-Liang Zhang，Efficient extraction of intracellular reduced glutathione from fermentation broth of Saccharomyces cerevisiae by ethanol，Bioresource Technology，2009，100 :1011–1014
52. Zhen-Lin Li, Yong-Hong Wang , Ju Chu , Ying-Ping Zhuang and Si-Liang Zhang，Leucine improves the component of isovalerylspiramycins for the production of bitespiramycin，Bioprocess & Biosystem Engineering, 2009, 32: 641-647
53. Hui Hu, Jiangchao Qian, Ju, Yonghong, Yingping Zhuang , Siliang Zhang,Optimization of l-methionine feeding strategy for improving S-adenosyl-l-methionine production by methionine adenosyltransferase overexpressed Pichia pastoris，Applied Microbiology & Biotechnology, 2009, 83 (6): 1105-1114
54. Hui Hu, Jiangchao Qian, Ju, Yonghong, Yingping Zhuang , Siliang Zhang, DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-l-methionine production in Pichia pastoris, Journal of Biotechnology, 2009, 141: 97–103
55. Xiang Zou, Hai-feng Hang , Ju Chu, Ying-ping Zhuang, Si-liang Zhang , Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase，Bioresource Technology,2009,100 (13) :3358-3365
56. Taicheng Zhu, Meijin Guo, Chen Sun, Jiangchao Qian , Yingping Zhuang, Ju Chu,Siliang Zhang ,A systematical investigation on the genetic stability of multi-copy Pichia pastoris strains，Biotechnology Letters, 2009, 31(5) : 679-684
57. Bin-Quan Gou, Ju Chu , Siliang Zhang, Yonghong Wang, Yingping Zhuang, Hua Huang, Zhen Li , Zhong-YiYuan ,Production of penicillin G amidase from Alcaligenes faecalis in a recombinant Escherichia coli，Journal of the Taiwan Institute of Chemical Engineerings, 2009, 40(2) : 233-236
58. Haifeng Hang, Xinhao Ye, Meijin Guo，Ju Chu, Yingping Zhuang, Ming Zhang, Siliang Zhang，A simple fermentation strategy for high-level production of recombinant phytase by Pichia pastoris using glucose as the growth substrate，Enzyme & Microbial Technology, 2009, 44 (4) :185-188
59. Jian-Ye Xia, Yong-Hong Wang, Si-Liang Zhang, Ning Chen, Peng Yin, Ying-Ping Zhuang, Ju
    Chu,Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment, Biochemical Engineering Journal , 2009,43: 252–260
60. Yong Wang ,Ju Chu,Yingping Zhuang ,Yonghong Wang ,Jianye Xia,Siliang Zhang, Industrial bioprocess control and optimization in the context of systems biotechnology, Biotechnology Advances,2009, 27(6): 989-995
61. Li X, Wang YH, Zhang SL, Chu J, Zhang M, Huang MZ, Zhuang YP , Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using a novel strategy - shaking and extra-light supplementation approach，International Journal of Hydrogen Energy, 2009, 34(24) : 9677-9685
62. Guo-Qian Xu, Ju Chu, Ying-Ping Zhuang, Yong-Hong Wang, Si-Liang Zhang, Effects of vitamins on the lactic acid biosynthesis of Lactobacillus paracasei NERCB 0401.Biochemical Engineering Journal. 2008, 38(2):189-197
75. Yun Chen, Wei Deng, Jiequn Wu, Jiangchao Qian, Ju Chu, Yingping Zhuang, Siliang Zhang and Wen Liu. Genetic Modulation of the Overexpression of Tailoring Genes eryK and eryG Leading to the Improvement of Erythromycin A Purity and Production in Fermentation of Saccharopolyspora erythraea. Applied and Environmental Microbiology. 2008, 74(6): 1820-1828.（4.004）
63. Jin Zhou, Ju Chu, Yong-Hong Wang, Si-Liang Zhang, Ying-Ping Zhuang, Zhong-Yi Yuan, Purification and properties of Saccharomyces cerevisiae S-adenosylmethionine synthetase expressed in recombinant Pichia pastoris. World Journal of Microbiology & Biotechnology, 2008, 24(6):789–796
64. Zhou J, Wang YH, Chu J, Gou BQ, Zhuang YP, Zhang SL and Yuan ZY. Penicillin G acylase purification with the aid of high-throughput screening approach. Journal of the Chinese Institute of Chemical Engineers, 2008, 39: 195-202. （0.431）
65. Peng Yin, Yong-Hong Wang, Si-Liang Zhang, Ju Chu, Ying-Ping Zhuang, Mei-Long Wang, Jin Zhou， Isolation of soluble proteins from an industrial strain Streptomyces avermitilis in complex culture medium for two-dimensional gel electrophoresis. Journal of Microbiological Methods. 2008,73 (2) 105–110（2.153）
66. Feng Lei, Guo Meijin, Zhang Shuxiang, Chu Ju, Zhuang Yingping, Zhang Siliang, Improvement in the suspension-culture production of recombinant adeno-associated virus-LacZ in HEK-293 cells using polyethyleneimine –DNA complexes in combination with hypothermic treatment. Biotechnology and Applied Biochemistry, 2008, 50: 121-132
67. Ziqiang Xiong ,Meijin Guo ,Yuanxin Guo,Ju Chu ,Yingping Zhuang ,Siliang Zhang. Real-time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium. Journal of Bioscience and Bioengineering, 2008, 105(4): 409-413.（1.782）
68. Zhou J, Wang YH, Chu J, Zhuang YP, Zhang SL and Yin P. Identification and purification of the main components of cellulases from a mutant strain of Trichoderma viride T 100-14. Bioresource Technology, 2008, 99: 6826–6833.（3.103）
69. Kun-Tai Li, Dong-Hong Liu, Ju Chu, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang. An effective and simplified pH-stat control strategy for the industrial fermentation of vitamin B12 by Pseudomonas denitrificans. Bioprocess and Biosystems Engineering, 2008, 31（6）：606-610
70. Kun-Tai Li, Dong-Hong Liu, Ying-Ping Zhuang, Yong-Hong Wang, Ju Chu, Si-Liang Zhang. Influence of Zn2+, Co2+ and dimethylbenzimidazole on vitamin B12 biosynthesis by Pseudomonas denitrificans . World Journal of Microbiology and Biotechnology, 2008, 24（11）：2525-2530
71. Kun-Tai Li, Dong-Hong Liu, Yong-Liang Li, Ju Chu,Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang. Improved large-scale production of vitamin B12 by Pseudomonas denitrificans with betaine feeding. Bioresource Technology, 2008, 99（17）：8516-8520
72. Xiao-Qing Hu, Ju Chu, Zhuo Zhang, Si-Liang Zhang, Ying-Ping Zhuang, Yong-Hong Wang, Mei-Jin Guo, Hua-Xin Chen, Zhong-Yi Yuan. Effects of different glycerol feeding strategies on S-adenosyl-L-methionine biosynthesis by PGAP-driven Pichia pastoris overexpressing methionine adenosyltransferase. Journal of Biotechnology ,2008, 137(1-4):44-49
73. Xiang Zou, Hai-feng Hang, Chang-fa Chen, Ju Chu, Ying-ping Zhuang, Si-liang Zhang，Application of oxygen uptake rate and response surface methodology for erythromycin production by Saccharopolyspora erythraea. J Ind Microbiol Biotechnol 2008, 35:1637–1642
74. Meijin Guo, Haifeng Hang, Taicheng Zhu, Yingpin Zhuang, Ju Chu, Siliang Zhang. Effect of glycosylation on biochemical characterization of recombinant phytase expressed in Pichia pastoris. Enzyme and Microbial Technology，2008，42（4）：340-345
75. Mei-jin Guo, Ying-ping Zhuang, Ju Chu, Si-liang Zhang, Ai-sheng Xiong, Ri-he Peng, and Quan-hong Yao. Production and purification of a novel thermostable phytase by Pichia pastoris FPHY34. Process Biochemistry, 2007, 42（12）：1660-1665
76. Wang Yong, Wang Yiguang, Chu Ju, Zhuang Yingping, Zhang Lixin, Zhang Siliang,Improved production of erythromycin A by expression of a heterologous gene encoding S-adenosylmethionine synthetase ,Applied Microbiology and Biotechnology,2007, 75 (4): 837-842
77. Hu Xiaoqing, Chu Ju, Zhang Siliang, Zhuang Yingping, Wang Yonghong, Zhu Shan, Zhu Zhigang, Yuan Zhongyi, A novel feeding strategy during the production phase for enhancing the enzymatic synthesis of S-adenosyl-L-methionine by methylotrophic Pichia pastoris ,Enzyme and Microbial Technology, 2007, 40 (4): 669-674
78. Hao Yuyou, Chu Ju, Wang Yonghong, Zhuang Yingping, Zhang Siliang, The inhibition of aggregation of recombinant human consensus interferon-alpha mutant during Pichia pastoris fermentation , Applied Microbiology and Biotechnology ,2007,74 (3): 578-584
79. Siliang Zhang, Bangce Ye, Ju Chu, Yingping Zhuang, Meijin Guo, From multi-scale methodology to systems biology: to integrate strain improvement and fermentation optimization, Journal of Chemical Technology and Biotechnology, 2006,81 (5): 734-745
80. Jiangchao Qian, Xianpeng Cai, Ju Chu, Yingping Zhuang, Siliang Zhang, Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine-and inosine-producing Bacillus subtilis strains. Biotechonlogy Letter, 2006, 28:937-941
81. Guo-qian Xu, Ju Chu, Yong-hong Wang, Ying-ping Zhuang, Si-liang Zhang and Hua-qiong Peng. Development of a continuous cell-recycle fermentation system for production of lactic acid by Lactobacillus paracasei. Proces .Biochemistry, 41(12): 2458-2463, 2006.
82. Zhuang Yingping, Ma Wenfeng, Guo Meijin, Ding Mansheng, Chu Ju, Zhang Siliang, High cell density and high expression of recombinant human ApoA-IMilano in Escherichia coli by twice temperature-shifted induction, Frontiers of Biology in China, 2006, 1(4):345-348

專著：

1. Siliang Zhang,Xuejun Cao,Ju Chu,Jiangchao Qian ,Yingping Zhuang ,Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Envronment. Advances in Biochemical Engineering-Biotechnology.2010, 122: 105-150
2. Siliang Zhang, Ju Chu, Yingping Zhuang, A Multi-Scale Study of Industrial Fermentation Processes and Their Optimization, Adv Biochem Engin/Biotechnol , 87: 97–150, 2004

專利授權(quán)與申請(qǐng)：

一、專利授權(quán) ：

1. 一種提高肌苷發(fā)酵過(guò)程糖苷轉(zhuǎn)化率及產(chǎn)率的方法，發(fā)明申請(qǐng)?zhí)枺?00310122798.9，申請(qǐng)日期：2003-12-25,授權(quán)號(hào)： ZL 2003 1 0122798.9, 授權(quán)日期：2006-01-04, 申請(qǐng)人：儲(chǔ)炬，陳雙喜，張嗣良，莊英萍
2. 一種蚯蚓纖溶酶及其編碼序列與用途，發(fā)明專利申請(qǐng)?zhí)枺?00510023241.9，申請(qǐng)日期：2005-01-12, 專利授權(quán)號(hào)ZL 2005 1 0023241.9，授權(quán)日：2007-12-19，申請(qǐng)人：儲(chǔ)炬，黃文華，秦奕輝，莊英萍，張嗣良
3. 一種制備硫腺苷甲硫氨酸的改進(jìn)方法，發(fā)明專利申請(qǐng)?zhí)枺?00510025183.3，申請(qǐng)日期：2005-04-19, 專利授權(quán)號(hào) ZL 2005 1 0025183.3，授權(quán)日：2008-1-30，申請(qǐng)人：張嗣良，儲(chǔ)炬，胡曉清，朱志鋼，朱閃，莊英萍，王永紅
4. 一種重組復(fù)合α干擾素的制備方法，專利號(hào)申請(qǐng)?zhí)枺?00510028285.0 申請(qǐng)日期：2005-07-29, 專利授權(quán)號(hào)ZL 2005 1 0028285.0，授權(quán)日：2008-3-5，申請(qǐng)人：儲(chǔ)炬，郝玉有，張嗣良，莊英萍，史琪琪，王永紅，杭海峰，劉志敏
5. 一種新的腺苷甲硫氨酸的體外酶促轉(zhuǎn)化方法, 申請(qǐng)?zhí)枺?00610024158.8, 申請(qǐng)日期：2006-02-27, 專利授權(quán)號(hào)ZL 2006 1 0024158.8，授權(quán)日：2008-1-23，申請(qǐng)人：莊英萍，武鑫，儲(chǔ)炬，張嗣良，胡曉清，袁中一
6. 一種S-腺苷甲硫氨酸生產(chǎn)菌株的構(gòu)建及大規(guī)模發(fā)酵，申請(qǐng)?zhí)枺?00610117828.0，申請(qǐng)日期：2006-11-1，授權(quán)專利號(hào)：ZL 2006 1 0117828.0，授權(quán)日期：2009-9-9，申請(qǐng)人：儲(chǔ)炬，胡輝，王勇，張嗣良，莊英萍
7. 組成型大腸干菌基因工程菌的發(fā)酵工藝, 申請(qǐng)?zhí)枺?00610024465.6,申請(qǐng)日期：2006-03-08, 公開(kāi)號(hào)：CN1821386A，申請(qǐng)人：張嗣良，儲(chǔ)炬，茍斌全，莊英萍，黃華，李震，王永紅
8. 一種新的發(fā)酵生產(chǎn)乳酸的培養(yǎng)基配方，申請(qǐng)?zhí)枺?00610118858.3，申請(qǐng)日期：2006-11-29，公開(kāi)號(hào)：CN1962851A，申請(qǐng)人：莊英萍，邱伙琴，徐國(guó)謙，儲(chǔ)炬，張嗣良，王永紅
9. 一種發(fā)酵生產(chǎn)S-腺苷甲硫氨酸的方法，申請(qǐng)?zhí)枺?00710036807.0，申請(qǐng)日期：2007-1-24，公開(kāi)號(hào)CN101012470A，專利號(hào)：ZL200710036807.0，申請(qǐng)人：儲(chǔ)炬，張卓，張嗣良，莊英萍，王永紅，胡曉清，袁中一
10. 重組的降糖肽及其生產(chǎn)菌株的構(gòu)建和培養(yǎng)方法，申請(qǐng)?zhí)枺?00710037133.6，申請(qǐng)日期：2007-2-5，公開(kāi)號(hào)CN101029081A，申請(qǐng)人：莊英萍，王暉，儲(chǔ)炬，張嗣良，錢(qián)江潮，王永紅
11. 一種制備鏈霉菌全蛋白的方法，申請(qǐng)?zhí)枺?00710047439.X ，申請(qǐng)日期：2007-10-26日，公開(kāi)號(hào)：CN101157721A，專利授權(quán)號(hào)：ZL200710047439.X，申請(qǐng)人：王永紅, 銀鵬, 張嗣良, 莊英萍, 儲(chǔ)炬
12. 利用重組大腸桿菌高效生產(chǎn)丙酮酸氧化酶的培養(yǎng)基，申請(qǐng)?zhí)枺?00710047750.4，申請(qǐng)日期：2007-10-28，公開(kāi)號(hào)：CN101182486A，授權(quán)號(hào)：200710047750.4，申請(qǐng)人：張嗣良，趙劼，王永紅，儲(chǔ)炬，莊英萍，袁中一
13. 利用氧化還原電位調(diào)控乳酸發(fā)酵，申請(qǐng)?zhí)?00810034199.4，申請(qǐng)日期：2008年3月4日，公開(kāi)號(hào)：CN101235397A，專利號(hào)：ZL200810034199.4，授權(quán)日：2010年12月8日，申請(qǐng)人：王永紅，儲(chǔ)炬，鄭繼岱，徐國(guó)謙，莊英萍，張嗣良
14. 基于氧化還原電位自動(dòng)反饋調(diào)控厭氧發(fā)酵生產(chǎn)乙醇的方法，申請(qǐng)日期：2008年9月26日，申請(qǐng)?zhí)枺?00810200505.7，公開(kāi)號(hào)：CN101358210A，專利號(hào)：ZL200810200505.7，申請(qǐng)人：杭海峰，王永紅，王強(qiáng)，儲(chǔ)炬，莊英萍，鄭超，張嗣良
15. 一種重組人復(fù)合α干擾素（cIFN）異構(gòu)體的分離方法，申請(qǐng)日期：2008年5月16日，申請(qǐng)?zhí)枺?00810037559.6，公開(kāi)號(hào)：CN101580533A，專利號(hào)：ZL200810037559.6，申請(qǐng)人：莊英萍，楊琪，郝玉有，儲(chǔ)炬，程杰，王維娜，符曉輝，張嗣良
16. 利用銨離子調(diào)控林可霉素發(fā)酵過(guò)程及提高林可霉素產(chǎn)素，申請(qǐng)日期2008年1月23日，申請(qǐng)?zhí)枺?00810032954.5，公開(kāi)號(hào)：CN101220385.A，專利號(hào)：ZL200810032954.5，申請(qǐng)人：儲(chǔ)炬，李嘯，張嗣良，莊英萍，鐘承贊，葛友群，杭海峰，王永紅，郭美錦，夏建業(yè)，章付林，楊明
17. 一種快速酶解混合蛋白質(zhì)的方法，申請(qǐng)?zhí)枺?00810207956.3，申請(qǐng)日期：2008年12月26日，授權(quán)號(hào)：ZL200810207956.3，授權(quán)日期：2011年11月9日，申請(qǐng)人：李友元，李雅萍，王永紅，陳長(zhǎng)華，儲(chǔ)炬，莊英萍，張嗣良
18. 微孔板固定裝置，申請(qǐng)?zhí)枺?00920068480.X，專利號(hào)：ZL2009200688480.X，申請(qǐng)日期：2009年3月5日，申請(qǐng)人：郝玉有，儲(chǔ)炬，莊英萍，張嗣良（實(shí)用新型）
19. 一種微孔板盤(pán)，申請(qǐng)?zhí)枺?00920068504.1，專利號(hào)：ZL200920068504.1,申請(qǐng)日期：2009年3月6日，申請(qǐng)人：郝玉有，儲(chǔ)炬，莊英萍，張嗣良（實(shí)用新型）
20. GAP啟動(dòng)子文庫(kù)及其用途，申請(qǐng)?zhí)枺?00910053198.8，申請(qǐng)日期：2009年5月17日，公開(kāi)號(hào)：CN101922047A，專利號(hào)：ZL200910053198.8，授權(quán)日：2012年12月26日，申請(qǐng)人：錢(qián)江潮，秦秀林，儲(chǔ)炬，莊英萍，張嗣良，肖慈英
21. 基于生物信息的發(fā)酵過(guò)程工藝分析軟件（簡(jiǎn)稱發(fā)酵之星），登記號(hào)：2009SR027762，編號(hào)：軟著登字第0154761號(hào)，著作權(quán)人：華東理工大學(xué)
22. 基于生物信息的發(fā)酵過(guò)程控制軟件V1.0，登記號(hào)：2009SR027760，編號(hào)：軟著登字第0154759號(hào)，著作權(quán)人：華東理工大學(xué)
23. 基于振蕩-補(bǔ)光策略的新型光合生物制氫工藝，申請(qǐng)?zhí)枺?00910048227.2，公開(kāi)號(hào)：CN101845460A，專利號(hào)：ZL 200910048227.2，授權(quán)日：2012年，申請(qǐng)日期：2009-3-26，申請(qǐng)人：王永紅，張明，李旭，張嗣良，張波，儲(chǔ)炬，莊英萍，鮑杰
24. 提高脫氮假單胞桿菌維生素B12產(chǎn)量的方法200810034948.3申請(qǐng)日期：2008-03-21，專利授權(quán)號(hào)：ZL 200810034948.3，專利授權(quán)日：2013-04-17，申請(qǐng)人：張嗣良；趙強(qiáng)；李昆太；劉東洪；莊英萍；儲(chǔ)炬；王振國(guó)；李永亮
25. 基于氧消耗速率的維生素B12發(fā)酵生產(chǎn)控制工藝，專利申請(qǐng)?zhí)枺?00910196035.6，申請(qǐng)日期：2009-09-22，專利授權(quán)號(hào)：ZL200910196035.6，專利授權(quán)日：2013-04-17，申請(qǐng)人：張嗣良；王澤建；王慧媛；儲(chǔ)炬；莊英萍
26. 發(fā)酵聯(lián)動(dòng)裝置，申請(qǐng)?zhí)枺?01220588863.1，申請(qǐng)日期：2012年11月9日，專利授權(quán)號(hào)：ZL201220588863.1，授權(quán)日期：2013年5月8日，申請(qǐng)人：王澤建，張明，張劍坤，張嗣良，儲(chǔ)炬，莊英萍，郭美錦，黃明志，夏建業(yè)，杭海峰（實(shí)用新型）
27. 微型全息式生物傳感反應(yīng)器系統(tǒng)，申請(qǐng)?zhí)枺?01010176549.8，申請(qǐng)日期：2010年5月19日，專利授權(quán)號(hào)：ZL201010176549.8，專利授權(quán)日：2013年6月26日，申請(qǐng)人：黃明志，王澤建，張一鳴，陳麗，劉玉偉，儲(chǔ)炬，莊英萍，張嗣良
28. 一種可精確定時(shí)、定量并在位滅活的全自動(dòng)快速取樣設(shè)備，申請(qǐng)?zhí)枺?01310180350.0，申請(qǐng)日期：2013年5月15日，專利授權(quán)號(hào)：ZL201310180305.0，授權(quán)日期：2014年10月12日，申請(qǐng)人：黃明志，李敏超，王澤建，劉玉偉，儲(chǔ)炬，莊英萍，張嗣良
29. 基于工業(yè)以太網(wǎng)技術(shù)的發(fā)本地過(guò)程數(shù)據(jù)通信軟件，登記號(hào)：2013SR20247，授權(quán)日：2013年11月06日，開(kāi)發(fā)完成日期：2013年05月27日，著作權(quán)人：華東理工大學(xué)
30. 一種頭孢菌素C的發(fā)酵方法，申請(qǐng)?zhí)枺?01210429362.3，專利授權(quán)號(hào)：ZL201210429362.3，授權(quán)日期：2014年10月15日，申請(qǐng)日期：2012年10月31日，申請(qǐng)人：黎亮，張俊波，儲(chǔ)炬，李樹(shù)友，莊英萍，苗瑞春，張嗣良，陸俊
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